Pediatric Cardiology Featured Articles of September 2016

Early-Term Birth in Single-Ventricle Congenital Heart Disease after the Fontan Procedure: Neurodevelopmental and Psychiatric Outcomes.

Calderon J, Stopp C, Wypij D, DeMaso DR, Rivkin M, Newburger JW, Bellinger DC.

J Pediatr. 2016 Sep 27. pii: S0022-3476(16)30867-8. doi: 10.1016/j.jpeds.2016.08.084.

Take Home Points:

  1. This study from Boston Children’s Hospital found that infants born early term with single ventricle CHD are more likely to have decreased executive function in real-world contexts as teenagers compared to their similar counterparts born at full term (>39 weeks gestation).
  2. Adolescent, single ventricle Fontan patients born at early term were also diagnosed with ADHD twice as often as those born at full term.
  3. This study supports previous studies that early term delivery (i.e. delivery before 39 weeks gestation) should be avoided in fetuses with CHD.

Commentary from Dr. Ginnie Abarbanell picture small(Atlanta), section editor of Pediatric Cardiology Journal Watch: This cross-sectional cohort study from Boston Children’s Hospital compares the neurodevelopmental and psychiatric outcomes in single ventricle congenital heart disease (CHD) adolescents who have completed Fontan palliation. 133 adolescents (mean age 14.6 years) were included in this study. The full term group defined as birth after 39 weeks gestation included 100 patients and the early term group included 33 patients born between 37-38 weeks gestation. A battery of neurodevelopmental and psychiatric tests were performed and most of the adolescents had a recent brain MRI. There were no statistical differences between the two groups in regards to sex, race, and family social status. The groups also did not differ in terms of the incidence of fetal distress or the type of labor and delivery. The early term group did have lower birth weights and more cardiac catheterization complications. There were no differences in operative history or in structural abnormalities noted on brain MRI. The early term group was found to have lower performance on several of the neurodevelopmental and psychiatric tests. In particular, the early term group scored worse on parent and self-reported BRIEF scores, which indicate decreased executive function in daily life. Additionally, adolescents in the early term group were twice as likely to be diagnosed with ADHD (55% vs. 26%). The early term group was also associated with higher clinician rated psychiatric morbidity and more parent rated symptoms of posttraumatic stress. As the authors conclude: “Our results add to previous evidence indicating a higher incidence of morbidity in patients with critical CHD born early term and suggest that in the absence of fetal or maternal indications, the practice of elective delivery of newborns with a prenatal diagnosis of CHD at 37-38 weeks’ gestation should be avoided.”

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Mortality and complications in 3495 children with isolated ventricular septal defects.

Jortveit J, Leirgul E, Eskedal L, Greve G, Fomina T, Døhlen G, Tell GS, Birkeland S, Øyen N, Holmstrøm H.

Arch Dis Child. 2016 Sep;101(9):808-13. doi: 10.1136/archdischild-2015-310154. Epub 2016 Apr 18.

Take Home Points:

  1. Results from the nationwide research project ‘Congenital Heart Defects in Norway’ demonstrates an incidence of congenital heart defects (CHD) of 1.2% with isolated ventricular septal defects being the most common CHD diagnosis.
  2. This study found no increased mortality in infants/children with isolated VSDs compared to the general population.
  3. Cardiac complications secondary to isolated VSDs were rare ranging from 0-4.6‰ (0-0.6 per 1000 person-years)
  4. Given the low mortality and morbidity of isolated VSDs repeated follow up consultation in the majority of these children is unnecessary.

Commentary from Dr. Ginnie Abarbanell (Atlanta), section editor of Pediatric Cardiology Journal Watch: What is the natural history of isolated ventricular septal defects (VSDs) in the current era? Results from the nationwide research project ‘Congenital Heart Defects in Norway’ provides a strong answer to this question. This nationwide Norwegian project captured medical information on all live births (n=943,871) in Norway from 1994-2009. The incidence of congenital heart defects (CHD) was 1.2% in this population and isolated VSDs were the most common CHD diagnosis. Isolated VSDs were identified in 3989 infants (35.4% of all CHD). 494 children with isolated VSDs were excluded in this study secondary to documented chromosome and/or extracardiac anomalies. 5.2% (181) of isolated VSDs required surgical or catheter based interventions. Mortality in children with isolated VSDs was not increased compared to children with no CHD (Figure 1). Cardiac complications associated with isolated VSDs were rare (See Table 2). This study demonstrates that children with isolated VSDs are not at risk for increased mortality and the cardiac complications related to isolated VSDs are infrequent. As such the results support as noted by the authors “that repeated follow-up consultations of the majority of children with isolated VSDs are unnecessary during childhood”.

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Factors influencing bacteraemia in patients with isomerism and CHD: the effects of functional splenic status and antibiotic prophylaxis.

Loomba RS, Pelech AN, Anderson RH.

Cardiol Young. 2016 Sep 29:1-9. [Epub ahead of print]

Take Home Points:

  1. This retrospective study from Children’s Hospital of Wisconsin found that the majority of the cases of bacteremia in patients with congenital heart disease and isomerism were nosocomial.
  2. There were no variables found to be predictive of bacteremia in this population. In particular, splenic anatomy (asplenia or polysplenia) was not associated with an increased risk of bacteremia. Prophylactic antibiotics were not associated with decreased risk of bacteremia.
  3. The use of prophylactic antibiotics may not be effective in patients with CHD and isomerism in protecting from bacteremia.

Commentary from Dr. Ginnie Abarbanell (Atlanta), section editor of Pediatric Cardiology Journal Watch: This retrospective study from Children’s Hospital of Wisconsin evaluates the prevalence of bacteremia in patients with congenital heart disease (CHD) and isomerism. 83 patients with CHD and isomerism were included in this study. 17 (20%) had a documented episode of bacteremia. The most common bacterial organisms were coagulase negative Staphylococcus, Streptococcus viridans, and Escherichia coli followed by Enterococcus, Staphylococcus aureus and Streptococcus pneumonia. The majority of the infections were nosocomial (86%) occurring postoperatively with lines in place. Interesting, 78% of the patients with nosocomial infections were on prophylactic antibiotics at the time of infection. Only 33% of the bacteria isolated from the nosocomial infections were susceptible to amoxicillin. This would suggest that amoxicillin prophylaxis is not effective in presenting nosocomial infections, but rates of community acquired bacteremia in this sample were reduced in comparison to prior series (which authors point out may be related to increased prevalence of Hib and pneumococcal vaccines in comparison to prior series and/or that 60% of patients in this same with CHD and isomerism were on antibiotic prophylaxis). On Cox regression analysis there were no anatomical, operative or clinical variables predictive of bacteremia. See Table 1. These results suggest that the effectiveness of prophylactic antibiotics is unclear in patients with CHD and isomerism.

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How should we diagnose and differentiate hearts with double-outlet right ventricle?

Bharucha T, Hlavacek AM, Spicer DE, Theocharis P, Anderson RH.

Cardiol Young. 2016 Sep 19:1-15. [Epub ahead of print]

Take Home Points:

  1. According to this article, it is not the presence of bilateral conuses or percentage of arterial trunk override that defines double outlet right ventricle but rather the morphology of the “channel between the ventricles”.
  2. The “borders of the channel providing outflow from the morphological left ventricle” must be determined. “In the patients with double-outlet right ventricle, the cranial boundary of this channel is the inner heart curvature … rather than the outlet component of the ventricular septum.” See images.
  3. Additionally, if surgical repair requires a tunnel from the interventricular communication to one of the arterial roots vs. simple closure of the ventricular septal defect the underlying anatomy is consistent with double outlet right ventricle.

Commentary from Dr. Ginnie Abarbanell (Atlanta), section editor of Pediatric Cardiology Journal Watch: It has long been debated as how to define double outlet right ventricle. Does there need to be bilateral infundibulums (conuses) or can the diagnosis be made based on the percentage of the arterial trunk over-riding? This article from Bharucha et al would argue that neither of the above descriptions of double outlet right ventricle is correct. But rather it the morphology of the “channel between the ventricles” that leads to a more accurate diagnosis of double outlet right ventricle. According to this article, to appropriately diagnose double outlet right ventricle the “borders of the channel providing outflow from the morphological left ventricle” must be determined. “In the patients with double-outlet right ventricle, the cranial boundary of this channel is the inner heart curvature … rather than the outlet component of the ventricular septum.” See figures. Additionally, if surgical repair requires a tunnel from the interventricular communication to one of the arterial roots vs. simple closure of the ventricular septal defect the underlying anatomy is consistent with double outlet right ventricle.

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Pediatric Cardiology Articles – September 2016

 

  1. Anatomical considerations for the management of a left-sided superior caval vein draining to the roof of the left atrium.

Saundankar J, Ho AB, Salmon AP, Anderson RH, Magee AG.

Cardiol Young. 2016 Sep 29:1-5. [Epub ahead of print]

  1. A population-based analysis of mortality in patients with Turner syndrome and hypoplastic left heart syndrome using the Texas Birth Defects Registry.

Lara DA, Ethen MK, Canfield MA, Nembhard WN, Morris SA.

Congenit Heart Dis. 2016 Sep 29. doi: 10.1111/chd.12413. [Epub ahead of print]

  1. Postoperative assessment of left ventricular function by two-dimensional strain (speckle tracking) after paediatric cardiac surgery.

Perdreau E, Séguéla PE, Jalal Z, Perdreau A, Mouton JB, Nelson-Veniard M, Guillet E, Iriart X, Ouattara A, Roubertie F, Mauriat P, Thambo JB.

Arch Cardiovasc Dis. 2016 Sep 28. pii: S1875-2136(16)30137-1. doi: 10.1016/j.acvd.2016.03.005.

  1. Clinical phenotype and current diagnostic criteria for primary ciliary dyskinesia.

Dehlink E, Hogg C, Carr SB, Bush A.

Expert Rev Respir Med. 2016 Sep 28. [Epub ahead of print]

  1. Feasibility of ferumoxytol-enhanced neonatal and young infant cardiac MRI without general anesthesia.

Lai LM, Cheng JY, Alley MT, Zhang T, Lustig M, Vasanawala SS.

J Magn Reson Imaging. 2016 Sep 28. doi: 10.1002/jmri.25482. [Epub ahead of print]

  1. Preterm Thrombocytopenia and Delay of Ductus Arteriosus Closure.

Kulkarni VV, Dutta S, Sundaram V, Saini SS.

Pediatrics. 2016 Sep 28. pii: e20161627. [Epub ahead of print]

  1. 4D flow MRI demonstrates changes in cardiovascular haemodynamics in complex congenital heart disease.

Rose M, Rahman O, Schnell S, Robinson J, Rigsby C.

Eur Heart J Cardiovasc Imaging. 2016 Sep 27. pii: jew204. [Epub ahead of print] No abstract available.

  1. Three-dimensional printed models in congenital heart disease.

Cantinotti M, Valverde I, Kutty S.

Int J Cardiovasc Imaging. 2016 Sep 27. [Epub ahead of print] Review.

  1. Early-Term Birth in Single-Ventricle Congenital Heart Disease After the Fontan Procedure: Neurodevelopmental and Psychiatric Outcomes.

Calderon J, Stopp C, Wypij D, DeMaso DR, Rivkin M, Newburger JW, Bellinger DC.

J Pediatr. 2016 Sep 27. pii: S0022-3476(16)30867-8. doi: 10.1016/j.jpeds.2016.08.084.

  1. Use of 3D models of congenital heart disease as an education tool for cardiac nurses.

Biglino G, Capelli C, Koniordou D, Robertshaw D, Leaver LK, Schievano S, Taylor AM, Wray J.

Congenit Heart Dis. 2016 Sep 26. doi: 10.1111/chd.12414. [Epub ahead of print]

  1. Congenital Anorectal Malformation Severity Does Not Predict Severity of Congenital Heart Defects.

Jonker JE, Liem ET, Elzenga NJ, Molenbuur B, Trzpis M, Broens PM.

J Pediatr. 2016 Sep 26. pii: S0022-3476(16)30734-X. doi: 10.1016/j.jpeds.2016.08.047. [Epub ahead of print]

  1. Interventricular Septal Pseudoaneurysm After Blunt Chest Trauma in a 6 Year Old: An Illustrative Case and Review.

Behrle N, Dyke P, Dalabih A.

Pediatr Emerg Care. 2016 Sep 23. [Epub ahead of print]

  1. Creating Opportunities for Optimal Nutritional Experiences for Infants With Complex Congenital Heart Disease.

Steltzer MM, Sussman-Karten K, Kuzdeba HB, Mott S, Connor JA.

J Pediatr Health Care. 2016 Sep 22. pii: S0891-5245(16)30203-6. doi: 10.1016/j.pedhc.2016.08.002. [Epub ahead of print]

  1. Rehabilitation during congenital heart disease in pediatric patients.

Tian J, Xan X, Niu L.

Minerva Pediatr. 2016 Sep 22. [Epub ahead of print]

  1. Sildenafil, pulmonary hypertension and bronchopulmonary dysplasia.

Herbert S, Tulloh R.

Early Hum Dev. 2016 Sep 21. pii: S0378-3782(16)30416-9. doi: 10.1016/j.earlhumdev.2016.09.009. [Epub ahead of print]

  1. Speckle-Tracking Echocardiographic Measures of Right Ventricular Diastolic Function Correlate with Reference Standard Measures Before and After Preload Alteration in Children.

Chowdhury SM, Goudar SP, Baker GH, Taylor CL, Shirali GS, Friedberg MK, Dragulescu A, Chessa KS, Mertens L.

Pediatr Cardiol. 2016 Sep 21. [Epub ahead of print]

  1. Letter by Kochilas et al Regarding Article, “Report of the National Heart, Lung, and Blood Institute Working Group: An Integrated Network for Congenital Heart Disease Research”.

Kochilas LK, Oster ME, Spector LG.

Circulation. 2016 Sep 20;134(12):e256-7. doi: 10.1161/CIRCULATIONAHA.116.023194. No abstract available.

  1. Optimization of hybrid iterative reconstruction level and evaluation of image quality and radiation dose for pediatric cardiac computed tomography angiography.

Yang L, Zhuang J, Huang M, Liang C, Liu H.

Pediatr Radiol. 2016 Sep 16. [Epub ahead of print]

  1. Feasibility and utility of portable ultrasound during retrieval of sick term and late preterm infants.

Browning Carmo K, Lutz T, Berry A, Kluckow M, Evans N.

Acta Paediatr. 2016 Sep 15. doi: 10.1111/apa.13589. [Epub ahead of print]

  1. Usefulness of Lung Ultrasound in Neonatal Congenital Heart Disease (LUSNEHDI): Lung Ultrasound to Assess Pulmonary Overflow in Neonatal Congenital Heart Disease.

Rodríguez-Fanjul J, Llop AS, Balaguer M, Bautista-Rodriguez C, Hernando JM, Jordan I.

Pediatr Cardiol. 2016 Sep 13. [Epub ahead of print]

  1. Diverse multi-organ histopathologic changes in a failed Fontan patient.

Mizuno M, Ohuchi H, Matsuyama TA, Miyazaki A, Ishibashi-Ueda H, Yamada O.

Pediatr Int. 2016 Sep 11. doi: 10.1111/ped.13054. [Epub ahead of print]

  1. Pre-anesthetic echocardiographic findings in children undergoing non-cardiac surgery at the University of Benin Teaching Hospital, Nigeria.

Sadoh WE, Ikhurionan P, Imarengiaye C.

Cardiovasc J Afr. 2016 Sep 9;27:1-5. doi: 10.5830/CVJA-2016-006.

  1. Rapid 3D imaging of the lower airway by MRI in patients with congenital heart disease: A retrospective comparison of delayed volume interpolated breath-hold examination (VIBE) to turbo spin echo (TSE).

Goot BH, Patel S, Fonseca B.

Congenit Heart Dis. 2016 Sep 9. doi: 10.1111/chd.12408. [Epub ahead of print]

  1. Use of Tolvaptan in a Patient With Palliated Congenital Heart Disease.

Chakravarti S, Busovsky-McNeal M.

World J Pediatr Congenit Heart Surg. 2016 Sep 9. pii: 2150135116664319. [Epub ahead of print]

  1. Utility of genetic evaluation in infants with congenital heart defects admitted to the cardiac intensive care unit.

Ahrens-Nicklas RC, Khan S, Garbarini J, Woyciechowski S, D’Alessandro L, Zackai EH, Deardorff MA, Goldmuntz E.

Am J Med Genet A. 2016 Sep 8. doi: 10.1002/ajmg.a.37891. [Epub ahead of print]

  1. Autosomal and X chromosome structural variants are associated with congenital heart defects in Turner syndrome: The NHLBI GenTAC registry.

Prakash SK, Bondy CA, Maslen CL, Silberbach M, Lin AE, Perrone L, Limongelli G, Michelena HI, Bossone E, Citro R; BAVCon Investigators, GenTAC Registry Investigators, Lemaire SA, Body SC, Milewicz DM.

Am J Med Genet A. 2016 Sep 8. doi: 10.1002/ajmg.a.37953. [Epub ahead of print]

  1. KinCor, a national registry for paediatric patients with congenital and other types of heart disease in the Netherlands: aims, design and interim results.

Silva LM, Kuipers IM, van den Heuvel F, Mendes R, Berger RM, van Beynum IM, Rozendaal L, Rammeloo LA, van Iperen GG, Schokking M, Frerich S, Blom NA, Breur JM, Helbing WA.

Neth Heart J. 2016 Sep 8. [Epub ahead of print]

  1. Congenital Heart Disease in Lao People’s Democratic Republic: 2 Years’ Experience of the only Children’s Hospital.

Hwang IC, Sisavanh M, Billamay S, Phangmanixay S, Oudavong B, Kang J, Kwon BS, Kim GB, Bae EJ, Noh CI, Choi JY.

Pediatr Int. 2016 Sep 2. doi: 10.1111/ped.13156. [Epub ahead of print]

  1. Interstitial 1q23.3q24.1 deletion in a patient with renal malformation, congenital heart disease, and mild intellectual disability.

Mackenroth L, Hackmann K, Klink B, Weber JS, Mayer B, Schröck E, Tzschach A.

Am J Med Genet A. 2016 Sep;170(9):2394-9. doi: 10.1002/ajmg.a.37785. Epub 2016 Jun 3.

  1. Newborn Critical Congenital Heart Disease Screening Using Pulse Oximetry: Nursing Aspects.

Hom LA, Martin GR.

Am J Perinatol. 2016 Sep;33(11):1072-5. doi: 10.1055/s-0036-1586108. Epub 2016 Sep 7.

  1. Interplay of brain structure and function in neonatal congenital heart disease.

Birca A, Vakorin VA, Porayette P, Madathil S, Chau V, Seed M, Doesburg SM, Blaser S, Nita DA, Sharma R, Duerden EG, Hickey EJ, Miller SP, Hahn CD.

Ann Clin Transl Neurol. 2016 Aug 14;3(9):708-22. doi: 10.1002/acn3.336. eCollection 2016 Sep.

  1. Profile and risk factors for congenital heart defects: A study in a tertiary care hospital.

Abqari S, Gupta A, Shahab T, Rabbani MU, Ali SM, Firdaus U.

Ann Pediatr Cardiol. 2016 Sep-Dec;9(3):216-21. doi: 10.4103/0974-2069.189119.

  1. Pattern of congenital heart disease in a developing country tertiary care center: Factors associated with delayed diagnosis.

Rashid U, Qureshi AU, Hyder SN, Sadiq M.

Ann Pediatr Cardiol. 2016 Sep-Dec;9(3):210-5. doi: 10.4103/0974-2069.189125.

  1. Birth prevalence of congenital heart disease: A cross-sectional observational study from North India.

Saxena A, Mehta A, Sharma M, Salhan S, Kalaivani M, Ramakrishnan S, Juneja R.

Ann Pediatr Cardiol. 2016 Sep-Dec;9(3):205-9. doi: 10.4103/0974-2069.189122.

  1. Congenital heart disease profile: Four perspectives.

Kumar RK.

Ann Pediatr Cardiol. 2016 Sep-Dec;9(3):203-4. doi: 10.4103/0974-2069.189110. No abstract available.

  1. Mortality and complications in 3495 children with isolated ventricular septal defects.

Jortveit J, Leirgul E, Eskedal L, Greve G, Fomina T, Døhlen G, Tell GS, Birkeland S, Øyen N, Holmstrøm H.

Arch Dis Child. 2016 Sep;101(9):808-13. doi: 10.1136/archdischild-2015-310154. Epub 2016 Apr 18.

  1. How to use unfractionated heparin to treat neonatal thrombosis in clinical practice.

Bhatt MD, Paes BA, Chan AK.

Blood Coagul Fibrinolysis. 2016 Sep;27(6):605-14. doi: 10.1097/MBC.0000000000000469.

  1. Airway management in newborn with Klippel-Feil syndrome.

Altay N, Yüce HH, Aydoğan H, Dörterler ME.

Braz J Anesthesiol. 2016 Sep-Oct;66(5):551-3. doi: 10.1016/j.bjane.2014.03.006. Epub 2014 Apr 29.

  1. Impact of Pulmonary Hemodynamics and Ventricular Interdependence on Left Ventricular Diastolic Function in Children With Pulmonary Hypertension.

Burkett DA, Slorach C, Patel SS, Redington AN, Ivy DD, Mertens L, Younoszai AK, Friedberg MK.

Circ Cardiovasc Imaging. 2016 Sep;9(9). pii: e004612. doi: 10.1161/CIRCIMAGING.116.004612.

  1. Plastic Bronchitis.

Rubin BK.

Clin Chest Med. 2016 Sep;37(3):405-8. doi: 10.1016/j.ccm.2016.04.003. Epub 2016 Jun 15. Review.

  1. Neonatal Lupus: What We Have Learned and Current Approaches to Care.

Klein-Gitelman MS.

Curr Rheumatol Rep. 2016 Sep;18(9):60. doi: 10.1007/s11926-016-0610-z. Review.

  1. Association study involving polymorphisms in IL-6, IL-1RA, and CTLA4 genes and rheumatic heart disease in New Zealand population of Māori and Pacific ancestry.

Azevedo PM, Merriman TR, Topless RK, Wilson NJ, Crengle S, Lennon DR.

Cytokine. 2016 Sep;85:201-6. doi: 10.1016/j.cyto.2016.06.029. Epub 2016 Jul 9.

  1. Application of low dose radiation and low concentration contrast media in enhanced CT scans in children with congenital heart disease.

Liu Z, Song L, Yu T, Gao J, Zhang Q, Jiang L, Liu Y, Peng Y.

Int J Clin Pract. 2016 Sep;70 Suppl 9B:B22-8. doi: 10.1111/ijcp.12857.

  1. A Case Study of the Environmental Experience of a Hospitalized Newborn Infant With Complex Congenital Heart Disease.

Daniels JM, Harrison TM.

J Cardiovasc Nurs. 2016 Sep-Oct;31(5):390-8. doi: 10.1097/JCN.0000000000000273.

  1. Implementation of Developmental Screening Guidelines for Children with Congenital Heart Disease.

Knutson S, Kelleman MS, Kochilas L.

J Pediatr. 2016 Sep;176:135-141.e2. doi: 10.1016/j.jpeds.2016.05.029. Epub 2016 Jun 11.

  1. Pulse oximetry screening for critical congenital heart disease in planned out of hospital births and the incidence of critical congenital heart disease in the Plain community.

Miller KK, Vig KS, Goetz EM, Spicer G, Yang AJ, Hokanson JS.

J Perinatol. 2016 Sep 1. doi: 10.1038/jp.2016.135. [Epub ahead of print]

  1. Pulmonary atresia with intact ventricular septum and hypoplastic right ventricle in an Arabian foal.

Krüger MU, Wünschmann A, Ward C, Stauthammer CD.

J Vet Cardiol. 2016 Sep;18(3):284-9. doi: 10.1016/j.jvc.2016.04.002. Epub 2016 Jun 6.

  1. A novel de novo TBX5 mutation in a patient with Holt-Oram syndrome leading to a dramatically reduced biological function.

Dreßen M, Lahm H, Lahm A, Wolf K, Doppler S, Deutsch MA, Cleuziou J, Pabst von Ohain J, Schön P, Ewert P, Malcic I, Lange R, Krane M.

Mol Genet Genomic Med. 2016 Jul 14;4(5):557-67. doi: 10.1002/mgg3.234. eCollection 2016 Sep.

  1. Clinical classification in pediatric pulmonary arterial hypertension associated with congenital heart disease.

Zijlstra WM, Douwes JM, Ploegstra MJ, Krishnan U, Roofthooft MT, Hillege HL, Ivy DD, Rosenzweig EB, Berger RM.

Pulm Circ. 2016 Sep;6(3):302-12. doi: 10.1086/687764.

  1. Computed tomography features of supracardiac total anomalous pulmonary venous connection in an infant.

Alam T, Hamidi H, Hoshang MM.

Radiol Case Rep. 2016 May 14;11(3):134-7. doi: 10.1016/j.radcr.2016.04.005. eCollection 2016 Sep.

  1. Growth curves in Down syndrome with congenital heart disease.

Sica CD, Cesa CC, Pellanda LC.

Rev Assoc Med Bras (1992). 2016 Sep-Oct;62(5):414-20. doi: 10.1590/1806-9282.62.05.414.

  1. Longitudinal Echocardiographic Evaluation of an Unusual Presentation of X-Linked Myxomatous Valvular Dystrophy Caused by Filamin A Mutation.

Ma PH, Sachdeva R, Wilson EC, Guzzetta NA.

Semin Cardiothorac Vasc Anesth. 2016 Sep;20(3):240-5. doi: 10.1177/1089253216640088. Epub 2016 Mar 22.

  1. Echocardiographic Discovery of Doubled Interatrial Septum: An Incidental Finding.

Kumar PA, Martinelli SM, Kyle RW, Arora H.

Semin Cardiothorac Vasc Anesth. 2016 Sep;20(3):237-9. doi: 10.1177/1089253215584920. Epub 2015 Apr 30.

  1. [Congenitally corrected transposition of the great arteries in patient with atrial septal defect and acute inferior segment myocardial infarction].

Tosun V, Korucuk N, Karakaş MM, Güntekin Ü.

Turk Kardiyol Dern Ars. 2016 Sep;44(6):517-20. doi: 10.5543/tkda.2015.34624. Turkish.

  1. Anomalies of Ventriculoarterial Connections and Immature Brain Development.

Ishibashi N, Jonas RA.

World J Pediatr Congenit Heart Surg. 2016 Sep;7(5):611-3. doi: 10.1177/2150135116650650. No abstract available.

  1. The Challenges of Bedside-to-Bench Research in Pediatric Cardiology.

Holley C.

J Card Fail. 2016 Sep 30. pii: S1071-9164(16)31156-3. doi: 10.1016/j.cardfail.2016.09.021. No abstract available.

  1. Tricuspid atresia associated with aortopulmonary window: diagnostic and therapeutic dilemmas.

Milovanovic V, Stefanovic I, Ilic S.

Cardiol Young. 2016 Sep 29:1-4. [Epub ahead of print]

  1. Factors influencing bacteraemia in patients with isomerism and CHD: the effects of functional splenic status and antibiotic prophylaxis.

Loomba RS, Pelech AN, Anderson RH.

Cardiol Young. 2016 Sep 29:1-9. [Epub ahead of print]

  1. Congenital heart defects in Noonan syndrome and RIT1 mutation.

Calcagni G, Baban A, Lepri FR, Marino B, Tartaglia M, Digilio MC.

Genet Med. 2016 Sep 29. doi: 10.1038/gim.2016.137. [Epub ahead of print] No abstract available.

  1. [Comparison analysis of muscle enzymes in children with myocarditis and Duchene/Becker muscular dystrophy].

Zhang Y, Wang H, Yu X, Xing Y, Wang C, He R.

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Sep 28;41(9):984-91. doi: 10.11817/j.issn.1672-7347.2016.09.015. Chinese.

  1. 4D flow MRI demonstrates changes in cardiovascular haemodynamics in complex congenital heart disease.

Rose M, Rahman O, Schnell S, Robinson J, Rigsby C.

Eur Heart J Cardiovasc Imaging. 2016 Sep 27. pii: jew204. [Epub ahead of print] No abstract available.

  1. Low serum adiponectin levels in childhood and adolescence predict increased intima-media thickness in adulthood. The Cardiovascular Risk in Young Finns Study.

Saarikoski LA, Juonala M, Huupponen R, Viikari JS, Lehtimäki T, Jokinen E, Hutri-Kähönen N, Taittonen L, Laitinen T, Raitakari OT.

Ann Med. 2016 Sep 22:1-9. [Epub ahead of print]

  1. T1 mapping in children and young adults with hypertrophic cardiomyopathy.

Parekh K, Markl M, Deng J, de Freitas RA, Rigsby CK.

Int J Cardiovasc Imaging. 2016 Sep 22. [Epub ahead of print]

  1. Rehabilitation during congenital heart disease in pediatric patients.

Tian J, Xan X, Niu L.

Minerva Pediatr. 2016 Sep 22. [Epub ahead of print]

  1. Arterial dissection in childhood Takayasu Arteritis: not as rare as thought.

Aeschlimann FA, Grosse-Wortmann L, Benseler SM, Laxer RM, Hebert D, Yeung RS.

Pediatr Rheumatol Online J. 2016 Sep 22;14(1):56.

  1. To evaluate the prevalence of symptomatic and non-symptomatic ductus arteriosus and accuracy of physical signs in diagnosing PDA in preterm infants using blinded comparison of clinical and echocardiographic findings during the first week of life: a prospective observational study from Iran.

Pourarian S, Sharma D, Farahbakhsh N, Cheriki S, Bijanzadeh F.

J Matern Fetal Neonatal Med. 2016 Sep 21:1-5. [Epub ahead of print]

  1. Speckle-Tracking Echocardiographic Measures of Right Ventricular Diastolic Function Correlate with Reference Standard Measures Before and After Preload Alteration in Children.

Chowdhury SM, Goudar SP, Baker GH, Taylor CL, Shirali GS, Friedberg MK, Dragulescu A, Chessa KS, Mertens L.

Pediatr Cardiol. 2016 Sep 21. [Epub ahead of print]

  1. Near-infrared spectroscopy for detection of a significant patent ductus arteriosus.

Chock VY, Rose LA, Mante JV, Punn R.

Pediatr Res. 2016 Sep 21. doi: 10.1038/pr.2016.148. [Epub ahead of print]

  1. A rare cause of persisting anaemia in a patient with a failing Fontan circulation.

Lambrecht L, Cools B, Witters P.

Cardiol Young. 2016 Sep 20:1-2. [Epub ahead of print]

  1. Psychosocial health and quality of life among children with cardiac diagnoses: agreement and discrepancies between parent and child reports.

Patel BJ, Lai L, Goldfield G, Sananes R, Longmuir PE.

Cardiol Young. 2016 Sep 20:1-9. [Epub ahead of print]

  1. Implementation of a Clinical Pathway for Chest Pain in a Pediatric Emergency Department.

Mohan S, Nandi D, Stephens P, MʼFarrej M, Vogel RL, Bonafide CP.

Pediatr Emerg Care. 2016 Sep 20. [Epub ahead of print]

  1. How should we diagnose and differentiate hearts with double-outlet right ventricle?

Bharucha T, Hlavacek AM, Spicer DE, Theocharis P, Anderson RH.

Cardiol Young. 2016 Sep 19:1-15. [Epub ahead of print]

  1. Renal thromboembolism from a large pulmonary artery to a pulmonary vein fistula in an asymptomatic adolescent.

Brothers M, Peeler B, Paolillo J.

Cardiol Young. 2016 Sep 19:1-3. [Epub ahead of print]

  1. Foramen ovale (FO) – The underestimated sibling of ductus arteriosus (DA): Relevance during neonatal transition.

Baik N, Urlesberger B, Schwaberger B, Schmölzer GM, Köstenberger M, Avian A, Pichler G.

Early Hum Dev. 2016 Sep 17;103:137-140. doi: 10.1016/j.earlhumdev.2016.08.009. [Epub ahead of print] No abstract available.

  1. Identification of LAMP2 Mutations in Early-Onset Danon Disease With Hypertrophic Cardiomyopathy by Targeted Next-Generation Sequencing.

Fu L, Luo S, Cai S, Hong W, Guo Y, Wu J, Liu T, Zhao C, Li F, Huang H, Huang M, Wang J.

Am J Cardiol. 2016 Sep 15;118(6):888-94. doi: 10.1016/j.amjcard.2016.06.037. Epub 2016 Jun 27.

  1. A 12-year-old boy with chest pain and dyspnoea.

Latorre Navarro L, García-Guereta Silva L, Ruíz Bravo-Burguillos E.

Heart. 2016 Sep 15;102(18):1485. doi: 10.1136/heartjnl-2016-309394. Epub 2016 May 4.

  1. Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro.

Kalbitz M, Fattahi F, Herron TJ, Grailer JJ, Jajou L, Lu H, Huber-Lang M, Zetoune FS, Sarma JV, Day SM, Russell MW, Jalife J, Ward PA.

J Immunol. 2016 Sep 15;197(6):2353-61. doi: 10.4049/jimmunol.1600091. Epub 2016 Aug 12.

  1. Quantifying right atrial filling and emptying: A 4D-flow MRI study.

Callaghan FM, Arnott C, Figtree GA, Kutty S, Celermajer DS, Grieve SM.

J Magn Reson Imaging. 2016 Sep 14. doi: 10.1002/jmri.25457. [Epub ahead of print]

  1. Vortical flow characteristics of mechanical cavopulmonary assistance: Pre- and post-swirl dynamics.

Throckmorton AL, Chopski SG, Birewar SN, Joa TS, Huang P, Whitehead KK, Stevens RM, Kresh JY.

Technol Health Care. 2016 Sep 14;24(5):627-38. doi: 10.3233/THC-161154.

  1. Morphological Assessment of Single-Ventricle Atrioventricular Valve Regurgitation on Dual-Source 128-Slice Multidetector Computed Tomography and 4-Dimensional Imaging.

Kodama Y, Nakamura M, Sagawa K, Ishikawa S, Nakano T, Kado H.

Circ J. 2016 Sep 13. [Epub ahead of print] No abstract available.

  1. The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5.

Lessel D, Muhammad T, Casar Tena T, Moepps B, Burkhalter MD, Hitz MP, Toka O, Rentzsch A, Schubert S, Schalinski A, Bauer UM, Kubisch C, Ware SM, Philipp M.

Sci Rep. 2016 Sep 13;6:33231. doi: 10.1038/srep33231.

  1. Abnormal Central Pulsatile Hemodynamics in Adolescents With Obesity: Higher Aortic Forward Pressure Wave Amplitude Is Independently Associated With Greater Left Ventricular Mass.

Pierce GL, Pajaniappan M, DiPietro A, Darracott-Woei-A-Sack K, Kapuku GK.

Hypertension. 2016 Sep 12. pii: HYPERTENSIONAHA.116.07918. [Epub ahead of print]

  1. Evidence for troponin C (TNNC1) as a gene for autosomal recessive restrictive cardiomyopathy with fatal outcome in infancy.

Ploski R, Rydzanicz M, Ksiazczyk TM, Franaszczyk M, Pollak A, Kosinska J, Michalak E, Stawinski P, Ziolkowska L, Bilinska ZT, Werner B.

Am J Med Genet A. 2016 Sep 8. doi: 10.1002/ajmg.a.37860. [Epub ahead of print]

  1. A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene.

Ding Y, Long PA, Bos JM, Shih YH, Ma X, Sundsbak RS, Chen J, Jiang Y, Zhao L, Hu X, Wang J, Shi Y, Ackerman MJ, Lin X, Ekker SC, Redfield MM, Olson TM, Xu X.

JCI Insight. 2016 Sep 8;1(14). pii: e88797.

  1. NT-proBNP diagnostic algorithm for Kawasaki Disease compared to AHA Algorithm.

Dionne A, Meloche-Dumas L, Desjardins L, Turgeon J, Saint-Cyr C, Autmizguine J, Spigelblatt L, Fournier A, Dahdah N.

Pediatr Int. 2016 Sep 2. doi: 10.1111/ped.13154. [Epub ahead of print]

  1. An Innovative Pilot Curriculum Training Pediatric Residents in Referral and Communication Skills on a Cardiology Rotation.

Harahsheh AS, Ottolini M, Lewis K, Blatt B, Mitchell S, Greenberg L.

Acad Pediatr. 2016 Sep-Oct;16(7):700-2. doi: 10.1016/j.acap.2016.05.146. Epub 2016 Jun 7. No abstract available.

  1. Pattern of congenital heart disease in a developing country tertiary care center: Factors associated with delayed diagnosis.

Rashid U, Qureshi AU, Hyder SN, Sadiq M.

Ann Pediatr Cardiol. 2016 Sep-Dec;9(3):210-5. doi: 10.4103/0974-2069.189125.

  1. Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity.

Aminkeng F, Ross CJ, Rassekh SR, Hwang S, Rieder MJ, Bhavsar AP, Smith A, Sanatani S, Gelmon KA, Bernstein D, Hayden MR, Amstutz U, Carleton BC; CPNDS Clinical Practice Recommendations Group.

Br J Clin Pharmacol. 2016 Sep;82(3):683-95. doi: 10.1111/bcp.13008. Epub 2016 Jun 30. Review.

  1. Marfan syndrome associated aortic disease in neonates and children: a clinical-morphologic review.

Ware AL, Miller DV, Erickson LK, Menon SC.

Cardiovasc Pathol. 2016 Sep-Oct;25(5):418-22. doi: 10.1016/j.carpath.2016.06.002. Epub 2016 Jun 16.

  1. Left Ventricular Rotational Mechanics in Children After Heart Transplantation.

Nawaytou HM, Yubbu P, Montero AE, Nandi D, O’Connor MJ, Shaddy RE, Banerjee A.

Circ Cardiovasc Imaging. 2016 Sep;9(9). pii: e004848. doi: 10.1161/CIRCIMAGING.116.004848.

  1. Cardiovascular Magnetic Resonance Findings Late After the Arterial Switch Operation.

Shepard CW, Germanakis I, White MT, Powell AJ, Co-Vu J, Geva T.

Circ Cardiovasc Imaging. 2016 Sep;9(9). pii: e004618. doi: 10.1161/CIRCIMAGING.116.004618.

  1. Left Ventricular Diastolic Dysfunction in Pediatric Pulmonary Hypertension.

Hansmann G.

Circ Cardiovasc Imaging. 2016 Sep;9(9). pii: e005527. doi: 10.1161/CIRCIMAGING.116.005527. No abstract available.

  1. Right Ventricular Outflow Tract (RVOT) Changes in Children with an Atrial Septal Defect: Focus on RVOT Velocity Time Integral, RVOT Diameter, and RVOT Systolic Excursion.

Koestenberger M, Ravekes W, Avian A, Grangl G, Burmas A, Raith W, Cvirn G, Grillitsch M, Gamillscheg A.

Echocardiography. 2016 Sep;33(9):1389-96. doi: 10.1111/echo.13246.

  1. Changes in blood volume shunting in patients with atrial septal defects: assessment of heart function with cardiovascular magnetic resonance during dobutamine stress.

Stephensen SS, Steding-Ehrenborg K, Thilén U, Holm J, Hochbergs P, Arheden H, Carlsson M.

Eur Heart J Cardiovasc Imaging. 2016 Sep 1. pii: jew176. [Epub ahead of print]

  1. Spontaneous thrombosis of the ductus arteriosus in a newborn, complicated by thrombus migration and massive pulmonary embolism.

Ciliberti P, Esposito C, Drago F, Rinelli G.

Eur Heart J Cardiovasc Imaging. 2016 Sep;17(9):1026. doi: 10.1093/ehjci/jew108. Epub 2016 May 25. No abstract available.

  1. Association between ACR1 gene product expression and cardiomyopathy in children.

Wang Y, Niu L, He X, Xue Y, Ling N, Wang Z, An X.

Exp Ther Med. 2016 Sep;12(3):1711-1714. Epub 2016 Jul 5.

  1. Cardiovascular malformations caused by NOTCH1 mutations do not keep left: data on 428 probands with left-sided CHD and their families.

Kerstjens-Frederikse WS, van de Laar IM, Vos YJ, Verhagen JM, Berger RM, Lichtenbelt KD, Klein Wassink-Ruiter JS, van der Zwaag PA, du Marchie Sarvaas GJ, Bergman KA, Bilardo CM, Roos-Hesselink JW, Janssen JH, Frohn-Mulder IM, van Spaendonck-Zwarts KY, van Melle JP, Hofstra RM, Wessels MW.

Genet Med. 2016 Sep;18(9):914-23. doi: 10.1038/gim.2015.193. Epub 2016 Jan 28.

  1. Current views on anthracycline cardiotoxicity.

Mele D, Nardozza M, Spallarossa P, Frassoldati A, Tocchetti CG, Cadeddu C, Madonna R, Malagù M, Ferrari R, Mercuro G.

Heart Fail Rev. 2016 Sep;21(5):621-34. doi: 10.1007/s10741-016-9564-5.

  1. [OP.7C.05] AORTIC STIFFNESS AND PULSE WAVE ANALYSIS IN CHILDREN AND ADOLESCENTS WITH MARFAN SYNDROME.

Grillo A, Pini A, Gao L, Trifirò G, Marelli S, Viecca F, Salvi L, Salvi P, Rovina M, Carretta R, Parati G.

J Hypertens. 2016 Sep;34 Suppl 2:e91. doi: 10.1097/01.hjh.0000491570.34525.ef.

  1. Implementation of Developmental Screening Guidelines for Children with Congenital Heart Disease.

Knutson S, Kelleman MS, Kochilas L.

J Pediatr. 2016 Sep;176:135-141.e2. doi: 10.1016/j.jpeds.2016.05.029. Epub 2016 Jun 11.

  1. Procalcitonin (PCT) and Kawasaki Disease: Does PCT Correlate With IVIG-Resistant Disease, Admission to the Intensive Care Unit, or Development of Coronary Artery Lesions?

Dominguez SR, Martin B, Heizer H, Jone PN, Tong S, Davidson J, Anderson MS, Glodé MP.

J Pediatric Infect Dis Soc. 2016 Sep;5(3):297-302. doi: 10.1093/jpids/piv019. Epub 2015 Apr 20.

  1. Tacrolimus-associated hemolytic uremic syndrome in a pediatric heart transplant recipient.

Gray JM, Ameduri RK.

Pediatr Transplant. 2016 Sep;20(6):866-7. doi: 10.1111/petr.12744. Epub 2016 Jul 2.

  1. Clinical classification in pediatric pulmonary arterial hypertension associated with congenital heart disease.

Zijlstra WM, Douwes JM, Ploegstra MJ, Krishnan U, Roofthooft MT, Hillege HL, Ivy DD, Rosenzweig EB, Berger RM.

Pulm Circ. 2016 Sep;6(3):302-12. doi: 10.1086/687764.

  1. Diagnosis and follow-up of neonatal tetralogy of Fallot and hemitruncus with discontinuous pulmonary arteries noninvasively using awake ultra low-dose computed tomographic angiography.

Wheeler A, Vu D, Renella P.

Radiol Case Rep. 2016 Jun 24;11(3):138-41. doi: 10.1016/j.radcr.2016.05.009. eCollection 2016 Sep.

  1. Hypertrophic cardiomyopathy with Jeune syndrome: The first reported case.

Güvenç O, Sündüs Uygun S, Çimen D, Aslan E, Annagür A.

Turk Kardiyol Dern Ars. 2016 Sep;44(6):503-6. doi: 10.5543/tkda.2015.29677.

  1. Cardiac evaluation in children with hemangiomas.

Erdoğan İ, Sarıalioğlu F.

Turk Kardiyol Dern Ars. 2016 Sep;44(6):498-502. doi: 10.5543/tkda.2016.65171.

  1. EP05.10: Doppler assessment of hypertrophic cardiomyopathy in a case of Costello syndrome.

Kurihara Y, Tachibana D, Uemura R, Yokoi NW, Pooh RK, Kenji F, Kawauchi Y, Mika S, Suzuki T, Murakami Y, Yaoita M, Aoki Y, Koyama M.

Ultrasound Obstet Gynecol. 2016 Sep;48 Suppl 1:286-7. doi: 10.1002/uog.16856. No abstract available.

  1. Perspectives on HLHS From a Pediatric Cardiology Nurse.

Reed JM.

World J Pediatr Congenit Heart Surg. 2016 Sep;7(5):665-7. doi: 10.1177/2150135116662809. Review. No abstract available.

  1. Acute poststreptococcal glomerulonephritis and acute rheumatic fever: An uncommon coincidence.

Vilija C, Paulius K, Karolis A, Augustina J.

Ann Pediatr Cardiol. 2016 Sep-Dec;9(3):268-9. doi: 10.4103/0974-2069.189115. No abstract available.

  1. Acquired Fontan paradox in isolated right ventricular cardiomyopathy.

Saran M, Sivasubramonian S, Abhilash SP, Tharakan JA.

Ann Pediatr Cardiol. 2016 Sep-Dec;9(3):251-3. doi: 10.4103/0974-2069.189117.

  1. Thromboembolism and anticoagulation after Fontan surgery.

Viswanathan S.

Ann Pediatr Cardiol. 2016 Sep-Dec;9(3):236-40. doi: 10.4103/0974-2069.189109. Review.

  1. Profile and risk factors for congenital heart defects: A study in a tertiary care hospital.

Abqari S, Gupta A, Shahab T, Rabbani MU, Ali SM, Firdaus U.

Ann Pediatr Cardiol. 2016 Sep-Dec;9(3):216-21. doi: 10.4103/0974-2069.189119.

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