Congenital EP Featured Articles of March 2017

Congenital and Pediatric Cardiac EP Reviews of March 2017 Publications

 

Mechanisms and predictors of recurrent tachycardia after catheter ablation for d-transposition of the great arteries after the Mustard or Senning operation.

Gallotti RG, Madnawat H, Shannon KM, Aboulhosn JA, Nik-Ahd F, Moore JP.

Heart Rhythm. 2017 Mar;14(3):350-356. doi: 10.1016/j.hrthm.2016.11.031. Epub 2016 Nov 28.

PMID: 27908766

 

Take Home Points:

 

  • Intra-atrial reentrant remains the most common form of supraventricular tachyarrhythmia seen in D-transposition of the great arteries after Senning or Mustard operation
  • Recurrence after ablation occurs in nearly 1/3 of patients within less than 2 years
  • Of importance, recurrence of arrhythmias is often is due to an alternative arrhythmia mechanism rather than the prior ablated substrate
  • Clearly, the risk of arrhythmia recurrence differs between surgical technique with higher recurrent in patients who have undergone Senning operation.
  • Overall success rates after repeated ablation with short-term follow-up are very high (96%).

 

A PatelCommentary from Dr. Akash Patel (San Francisco), section editor of Congenital Electrophysiology Journal Watch:  This large single center study from UCLA aimed to improve our understanding of supraventricular tachyarrhythmia mechanisms after Senning and Mustard operations in patients with D-transposition of the great arteries and identify predictors for recurrence. Previous studies have looked at identifying arrhythmia mechanisms and ablation outcomes for arrhythmias after Mustard or Senning operations.  However, there is limited data regarding the difference between these 2 surgical techniques on mechanisms of arrhythmias and ablation outcomes.

 

This study included 28 patients who underwent 38 catheter ablations from 2004 – 2016. The majority underwent Mustard operation (64%).  89% were treated with antiarrhythmic drugs prior to ablation and 89% achieved initial ablation success.

 

At the time of initial ablation, the majority of arrhythmias were due to intra-atrial reentrant (70%). See Table and Figure Below.

EP media 1 ep media 2

Diagram depicting the sites of acutely successful catheter ablation for the initial catheter ablation procedures in a modified left anterior oblique view. For intra-atrial reentrant tachycardia (IART) that was successfully ablated at the cavotricuspid isthmus (CTI), the number of patients after either the Senning or the Mustard operation is totaled in parentheses. The systemic venous atrium is depicted in blue and the pulmonary venous atrium in pink. M = Mustard; S = Senning. IART, Focal atrial tachycardia, Atrioventricular nodal reentrant tachycardia.

 

Recurrence was seen in 9 patients (32%) with 7 (78%) achieving procedural success. Most recurrences were seen after Senning operation (60% vs. 17%, p =0.34).  In addition, no other risk factor including patients characteristics, arrhythmia mechanism, procedural characteristics were found to be predictive of recurrence.

 

At the time of repeat ablation, most arrhythmias mechanisms where due to intra-atrial reentrant (54%) but compromised a smaller portion compared to the initial procedure. See Table and Figure Below.

ep media 3

ep media 4
Of significant importance was that 10 of 13 (77%) arrhythmias seen during repeat procedure for recurrence were not seen in initial procedure. In particular, Senning operation conferred a higher risk of procedural recurrence with the location of the arrhythmia occurring in the pulmonary venous atrium in 4 out of 6 patients. Of the 3 cases identified at the prior procedure, 2 required ablation in the pulmonary venous atrium for the same mechanism approached only via the systemic venous atrium to achieve procedural success. Overall, 96% of patients remained arrhythmia-free after their final procedure with a median follow-up of 1.3 years.
Prior studies and this continue to demonstrate the significance of supraventricular tachyarrhythmia associated with adult with congenital heart disease.  This study highlights the importance of variations in surgical technique (Senning vs Mustard Operation) on arrhythmia mechanism.  In addition, previously perceived “failed ablations” more often are due to additional arrhythmia mechanisms.  These findings may warrant a more comprehensive approach at the initial procedure.

 

Genotypic and phenotypic predictors of complete heart block and recovery of conduction after surgical repair of congenital heart disease.

Murray LE, Smith AH, Flack EC, Crum K, Owen J, Kannankeril PJ.

Heart Rhythm. 2017 Mar;14(3):402-409. doi: 10.1016/j.hrthm.2016.11.010. Epub 2016 Nov 5.

PMID:27826129

 

Take Home Points:

 

  • Incidence of permanent post-operative complete heart block after congenital heart surgery has remained constant over the last decades around 1-3%.
  • In addition to direct trauma, inflammation, or edema to the AV node there may potential intrinsic factors that may place patients at risk for complete heart block.
  • A gap junction protein, connexin-40, has been implicated in a familial form of complete heart block when malformed due to genetic mutations.
  • A common missense mutation polymorphism for GJA5 (genotype TT) that encodes connexin-40 was associated with a 2-fold increase in the risk of post-operative complete heart block that is similar to the risk that VSD closure confers.
  • Junctional arrhythmia and intermittent conduction were predictive of AV node recovery.
  • Early recovery of AV node function can still result in episodes of higher degree AV block during the post-operative period that necessitates pacemaker therapy.
  • Permanent AV block can rarely have late return of AV conduction.

 

Commentary from Dr. Akash Patel (San Francisco), section editor of Congenital Electrophysiology Journal Watch:  This large single center study from Vanderbilt aimed to improve our understanding of post-operative complete heart block with the assessment of a genetic polymorphism in the gap junction protein, connexin-40, in addition to typical risk factors including diagnosis, preoperative and operative characteristics.

 

This study included 1199 patients who underwent one or more congenital heart surgeries with cardiopulmonary bypass at Vanderbilt from 2007 to 2015.  The case mix was standard for congenital heart surgical program with the 5 most common diagnoses were tetralogy of Fallot (11.3%), ventricular septal defect (10.4%), hypoplastic left heart (9.2%), atrial septal defect (8.3%) and complete AV canal defect (7.3%). The primary surgical procedure involved a ventricular septal defect closure in 41% of the cases.  There were 56 patients (4.7%) who had complete heart block in the operating room or within the first 48 hours.

 

Perioperative risk factors associated with complete heart block included younger age, small size (weight), pre-operative digoxin use, and earlier surgical era. See Table below.

ep media 5Intraoperative risk factors associated with complete heart block included longer cardiopulmonary bypass time, longer aortic cross clamp time, and procedures with ventricular septal defect closure based on univariate analysis. See Table below.

 

 

ep media 6
Post-operative risk factors associated with complete heart block included use of dopamine, use of milrinone, lower pO2, higher lactate on admission to CICU, higher ionized calcium on admission to CICU, need for post-operative ecmo, longer duration of mechanical ventilation, longer CU and hospital length of stay, and increased mortality based on univariate analysis. See Table below.

ep media 7
Genetic risk factors of GJA5 rs10465885 TT genotype polymorphism was associated with increased risk of complete heart block based on univariate analysis.  There were 3 genotype polymorphisms seen in the total cohort C/C (n = 245, 20%), T/C (n=607, 51%), and T/T (n=347, 29%). Overall risk for complete heart block by genotype was 2.8% for C/C, 3.9% for C/T, and 7.2% for T/T. See table below.

ep media 8
On multivariate analysis, use of pre-op digoxin, procedure with VSD closure, and prolonged aortic cross clamp time conferred increased risk. In addition, the presence of the GJA5 polymorphism with TT genotype carried a 2.1-fold risk comparable to the 2.2-fold risk with VSD closure.  See table below.

ep media 9

Recovery of AV node function was seen in 35 of the 56 patients (63%) and pacemaker free recovery was seen in 27 patients (48%) with a median recovery time of 3 days.  Based on assessment of the same pre-operative, intraoperative, post-operative, and genetic risk factors; only pre-operative ACE inhibitor use, intermittent AV conduction, and junctional acceleration (junctional ectopic tachycardia and accelerated junctional rhythm) were associated with recovery of AV node function. Multivariate analysis demonstrated only intermittent AV conduction (Adjusted OR of 9.1) and junctional acceleration (Adjusted OR of 4) were associate with recovery with positive predictive value of 89%.  Of interest were 8 patients with recovery had a pacemaker implanted but 6 (75%) had evidence of 2nd degree or higher AV block. Three had evidence of transient high grade AV block and 3 had evidence of residual conduction disease with first degree and periods of second degree AV block.  All patients received their devices between 7 and 21 days post-operatively.

 

Permanent heart block was seen in 1.4% of the total group. Of interest was late recurrent of AV conduction was seen in 1 patient noted at 101 days post-operative who had pacemaker implanted after nearly 2 weeks of complete heart block.

 

This study raises the intriguing possibility of genetic risks factors for post-operative AV block in addition the conventional wisdom of trauma from surgery.  Further investigation looking at other intrinsic factors may provide for insights into patient specific vulnerability for AV block.

 

 

 

Additional Articles.

 

  1. 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients with Syncope: A Report of the American College of Cardiology/American HeartAssociation Task Force on Clinical Practice Guidelines, and the HeartRhythm Society.

Shen WK, Sheldon RS, Benditt DG, Cohen MI, Forman DE, Goldberger ZD, Grubb BP, Hamdan MH, Krahn AD, Link MS, Olshansky B, Raj SR, Sandhu RK, Sorajja D, Sun BC, Yancy CW.

Heart Rhythm. 2017 Mar 9. pii: S1547-5271(17)30297-7. doi: 10.1016/j.hrthm.2017.03.004. [Epub ahead of print] No abstract available.

PMID: 28286247

 

  1. Genotype-Phenotype Correlation of SCN5AMutation for the Clinical and Electrocardiographic Characteristics of Probands with Brugada Syndrome: A Japanese Multicenter Registry.

Yamagata K, Horie M, Aiba T, Ogawa S, Aizawa Y, Ohe T, Yamagishi M, Makita N, Sakurada H, Tanaka T, Shimizu A, Hagiwara N, Kishi R, Nakano Y, Takagi M, Makiyama T, Ohno S, Fukuda K, Watanabe H, Morita H, Hayashi K, Kusano K, Kamakura S, Yasuda S, Ogawa H, Miyamoto Y, Kapplinger JD, Ackerman MJ, Shimizu W.

Circulation. 2017 Mar 24. pii: CIRCULATIONAHA.117.027983. doi: 10.1161/CIRCULATIONAHA.117.027983. [Epub ahead of print]

PMID:28341781

 

CHD EP March 2017

 

  1. Sudden Cardiac Death in Pre-Excitation and Wolff-Parkinson-White: Demographic and Clinical Features.

Finocchiaro G, Papadakis M, Behr ER, Sharma S, Sheppard M.

J Am Coll Cardiol. 2017 Mar 28;69(12):1644-1645. doi: 10.1016/j.jacc.2017.01.023. No abstract available.

PMID:

 

28335848

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  1. Familial Catecholamine-Induced QT Prolongation in Unexplained Sudden Cardiac Death.

Huchet F, Kyndt F, Barc J, Thollet A, Charpentier F, Redon R, Schott JJ, le Marec H, Probst V, Gourraud JB.

J Am Coll Cardiol. 2017 Mar 28;69(12):1642-1643. doi: 10.1016/j.jacc.2017.01.030. No abstract available.

PMID:

 

28335847

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  1. Ablation of supraventricular arrhythmias in adultcongenital heart disease: A contemporary review.

Combes N, Derval N, Hascoët S, Zhao A, Amet D, Le Bloa M, Maltret A, Heitz F, Thambo JB, Marijon E.

Arch Cardiovasc Dis. 2017 Mar 27. pii: S1875-2136(17)30046-3. doi: 10.1016/j.acvd.2017.01.007. [Epub ahead of print] Review.

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28359691

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Holst KA, Said SM, Nelson TJ, Cannon BC, Dearani JA.

Circ Res. 2017 Mar 17;120(6):1027-1044. doi: 10.1161/CIRCRESAHA.117.309186.

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Lee A, Kite J, Davison O, Haqqani HM.

Heart Rhythm. 2017 Mar 16. pii: S1547-5271(17)30300-4. doi: 10.1016/j.hrthm.2017.03.007. [Epub ahead of print] No abstract available.

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  1. 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients with Syncope: A Report of the American College of Cardiology/AmericanHeartAssociation Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society.

Shen WK, Sheldon RS, Benditt DG, Cohen MI, Forman DE, Goldberger ZD, Grubb BP, Hamdan MH, Krahn AD, Link MS, Olshansky B, Raj SR, Sandhu RK, Sorajja D, Sun BC, Yancy CW.

Heart Rhythm. 2017 Mar 9. pii: S1547-5271(17)30297-7. doi: 10.1016/j.hrthm.2017.03.004. [Epub ahead of print] No abstract available.

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28286247

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Shen WK, Sheldon RS, Benditt DG, Cohen MI, Forman DE, Goldberger ZD, Grubb BP, Hamdan MH, Krahn AD, Link MS, Olshansky B, Raj SR, Sandhu RK, Sorajja D, Sun BC, Yancy CW.

Heart Rhythm. 2017 Mar 9. pii: S1547-5271(17)30298-9. doi: 10.1016/j.hrthm.2017.03.005. [Epub ahead of print] No abstract available.

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Varosy PD, Chen LY, Miller AL, Noseworthy PA, Slotwiner DJ, Thiruganasambandamoorthy V.

Heart Rhythm. 2017 Mar 9. pii: S1547-5271(17)30299-0. doi: 10.1016/j.hrthm.2017.03.006. [Epub ahead of print]

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  1. Ablation of Ventricular Tachycardia inCongenitaland Infiltrative Heart Disease.

Wijnmaalen AP, Zeppenfeld K.

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  1. Traumatic Gerbode ventricular septal defect and third-degree heart block.

Campbell MJ, Lodge AJ, Miller SG.

Cardiol Young. 2017 Mar;27(2):404-406. doi: 10.1017/S1047951116001359. Epub 2016 Sep 19.

PMID:

 

27641901

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  1. Lower spatial QRS-T angle rules out sustained ventricular arrhythmias in children with hypertrophic cardiomyopathy.

Cortez D, Sharma N, Cavanaugh J, Tuozo F, Derk G, Lundberg E, Weiner K, Kiciman N, Alejos J, Landeck B, Aboulhosn J, Miyamoto S, McCanta AC, Batra AS.

Cardiol Young. 2017 Mar;27(2):354-358. doi: 10.1017/S1047951116000640. Epub 2016 Jun 1.

PMID:

 

27246458

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  1. Radiofrequency ablation of atrial tachyarrhythmias in adults with tetralogy of Fallot – predictors of success and outcome.

Ezzat VA, Ryan MJ, O’Leary J, Ariti C, Deanfield J, Pandya B, Cullen S, Walker F, Khan F, Abrams DJ, Lambiase PD, Lowe MD.

Cardiol Young. 2017 Mar;27(2):284-293. doi: 10.1017/S1047951116000482. Epub 2016 May 26.

PMID:

 

27225323

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  1. Radiofrequency ablation versus cryoablation for atrioventricular nodal re-entrant tachycardia in children: a value comparison.

Oster ME, Yang Z, Stewart-Huey K, Glanville M, Porter A, Campbell R, Webb B, Strieper M.

Cardiol Young. 2017 Mar;27(2):224-228. doi: 10.1017/S1047951116000299. Epub 2016 Apr 18.

PMID:

 

27087499

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  1. Transseptal puncture for radiofrequency catheter ablations of left-sided arrhythmias in a paediatric population.

Ehrlinspiel DM, Gass M, Balmer C.

Cardiol Young. 2017 Mar;27(2):267-272. doi: 10.1017/S1047951116000457. Epub 2016 Apr 18.

PMID:

 

27086493

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Fetal Cardiology Featured Articles of March 2017

Fetal Cardiology Featured Reviews of March 2017 Publications

 

Does First-Trimester Screening Modify the Natural History of Congenital Heart Disease? Analysis of Outcome of Regional Cardiac Screening at 2 Different Time Periods.

Jicinska H, Vlasin P, Jicinsky M, Grochova I, Tomek V, Volaufova J, Skovranek J, Marek J.

Circulation. 2017 Mar 14;135(11):1045-1055. doi: 10.1161/CIRCULATIONAHA.115.020864. Epub 2017 Jan 31.

PMID: 28143885

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Select item 27908576 156.

 

 

Take Home Points:

  • Implementation of first trimester screening has changed the spectrum of CHD later in pregnancy and the outcome of fetuses diagnosed with CHD
  • Associated comorbidities (including chromosomal abnormalities) were more frequently found in fetuses diagnosed with CHD in the first trimester

 

Voges IngaCommentary from Dr. Inga Voges (London UK), section editor of Congenital Heart Surgery Journal Watch: This is a large retrospective study, which took place in Southern Moravia (Czech Republic). The authors analyzed the impact of first trimester screening on the spectrum of congenital heart defects (CHDs) later in pregnancy and outcomes of fetuses with CHDs.

 

Two major comparisons were performed (see figure 1):

1) Fetuses diagnosed with CHD in the first trimester were compared with fetuses who were diagnosed with CHD in the second trimester in the period between 2007-2013

2) Fetuses diagnosed with CHD in the second trimester before 2001 (first trimester screening was not routinely performed at that time) were compared with fetuses screened and diagnosed with CHDs only in the second trimester after 2007

 

127 fetuses in the first and 344 fetuses in the second trimester were diagnosed with CHD in the time from 2007 to 2013 (comparison 1).  The diagnoses of hypoplastic left heart syndrome, pulmonary atresia, and tricuspid atresia were significantly higher in the first trimester. The frequency of double outlet right ventricle transposition of great arteries, and pulmonary stenosis was higher in the second trimester. In the second trimester, more fetuses were diagnosed with aortic stenosis and vascular ring. Comorbidities, chromosomal abnormalities, noncardiac abnormalities, univentricular CHDs, intrauterine deaths, and terminations of pregnancy were more frequent in fetuses diagnosed with CHD in the first trimester (see figure 2).

 

Comparison 2 showed that before 2001 significantly more fetuses were diagnosed with hypoplastic left heart syndrome and pulmonary atresia compared with after 2007. Detection of coarctation of aorta, tetralogy of Fallot, vascular ring, and pulmonary stenosis was significantly higher in the second trimester after 2007. A significantly higher frequency of univentricular CHDs, intrauterine deaths and terminations of pregnancy were found in the second trimester from 1996-2001 compared with the second trimester from 2007-2013.

 

This study shows that the implementation of first trimester screening has moved the detection of cardiac abnormalities to early stages of gestation. The authors conclude furthermore that first trimester screening has an important impact on the spectrum of CHD later in pregnancy and on the outcome of fetuses with a CHD.

 fetal media 1

 fetal media 2

 

 Prenatal Diagnosis of the Criss-Cross Heart.

Ravi P, Fruitman D, Mills L, Colen T, Hornberger LK.

Am J Cardiol. 2017 Mar 15;119(6):916-922. doi: 10.1016/j.amjcard.2016.11.046. Epub 2016 Dec 18.

PMID:  28215417

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Select item 28087052 141.

 

Take Home Points

 

  • This is a 5 patient case series from Alberta, Canada detailing the fetal diagnosis of a criss-cross heart.
  • Authors give very useful “pointers” for making the diagnosis of criss-cross heart in the fetus.
  • Authors also provide an excellent review of the literature regarding this rare heart defect.

 

Commentary from Dr. Ginnie Abarbanell (Atlanta), section editor of Fetal Cardiology Journal Watch:   Criss-cross heart is a rare congenital heart defect (CHD).  This defect occurs when the ventricles twist along the ventricular long axis without twisting of the atria.  This causes the inflow tracts to cross each other from hence the name criss-cross heart originates.  Criss-cross heart is a complex CHD which can be difficult to understand and image.  This article from Alberta reviews 5 cases of criss-cross heart diagnosed by fetal echocardiography as well as an excellent review of the literature.   In this article researchers state that criss-cross heart can be diagnosed with “slow cross-sectional sweeps from the upper abdomen demonstrating the relation of the visceral, atrial, ventricular, and great arterial connections and relations”.  Some keys points to fetal diagnosis of criss-cross heart as outlined in this article are as follows:

 

  1. “Inability to obtain a normal 4-chamber view and parallel AV connections by 2D and color Doppler” was seen in all cases of criss-cross heart.
  2. Sagittal sweeps of the fetal heart help determine spatial relation of the ventricle, ventricular septum and great arteries.
  3. A horizontal (parallel) position of the ventricular septum was a key finding in 4 of the 5 cases
  4. Authors of this article caution – “The leftward and superior location of the morphologic right ventricle can be confusing and may be misinterpreted as an L-looped (left sided) right ventricle. To overcome this, the concept introduced by Van Praagh, that the internal spatial organization of the ventricles (handedness) is independent of their location, is helpful.”

 

As the authors discuss the most common type of criss-cross heart is D-loop of the ventricle with discordant ventriculoarterial connection which was seen in 3 of the 5 cases in this case series.  This occurs when there is clockwise rotation of the ventricles relative to the atria which leads to the right-sided right atrium connecting to the leftward superior right ventricle and the left atrium connecting with an inferior left ventricle (superior-inferior orientation of ventricles).  Authors also discuss that the majority of patients with criss-cross heart often have a hypoplastic right ventricle and tricuspid valve, a ventricular septal defect, straddling of the AV valves with pulmonary stenosis and most require single ventricle palliation.  This article also includes useful fetal echocardiographic images to better understand this complex heart lesion.

fetal media 3

fetal media 4

 

Counseling Practices for Fetal Hypoplastic Left Heart Syndrome.

Walsh MJ, Verghese GR, Ferguson ME, Fino NF, Goldberg DJ, Owens ST, Pinto N, Zyblewski SC, Quartermain MD.

Pediatr Cardiol. 2017 Mar 27. doi: 10.1007/s00246-017-1601-1. [Epub ahead of print]

PMID:28345115

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Select item 28345114 86.

 

Take Home Points

 

  • This survey of pediatric cardiologists found that long term complications were commonly not discussed when counselling expectant families after a fetal diagnosis of hypoplastic left heart syndrome.
  • The survey also found significant variability in the setting and content of fetal counselling.
  • Standardization of current counselling practices and training which includes both the short and long term effects of surgical palliation of hypoplastic left heart syndrome is needed and would most likely help optimize a family’s understanding.

 

Abarbanell picture smallCommentary from Dr. Ginnie Abarbanell (Atlanta), section editor of Fetal Cardiology Journal Watch:  Often times the first discussion with a family after a fetal diagnosis of significant congenital heart disease can be challenging and heart wrenching.  Most fetal cardiologists struggle with not overwhelming the family but still conveying the options available including cardiac surgery, as well as comfort care or termination of the pregnancy in some cases.  This article reports the results of a web-based survey of pediatric cardiologists that perform fetal echocardiograms regarding their fetal counselling of expectant families with a fetus with hypoplastic left heart syndrome.  There were 201 physicians that responded.  The results of this survey found that most pediatric cardiologists discuss what families can expect during the first few years of life but the long term complications and outcomes are not as commonly discussed.  See figure. Many of the responders (74%) answered that they did not often counsel families of the long-term complications because “The information would be too overwhelming for the family”.  This study found significant variability in the setting and content of fetal counseling for hypoplastic left heart syndrome.  As the authors conclude “opportunities exist to broaden and standardize current counseling practices and training experiences in an effort to optimize a family’s understanding of the common short- and long-term effects of palliated HLHS physiology.

fetal media 5

 

 

Fetal Cardiology and genetics March 2017

 

  1. Exome sequencing reveals novel IRXI mutation incongenital heart disease.

Guo C, Wang Q, Wang Y, Yang L, Luo H, Cao XF, An L, Qiu Y, Du M, Ma X, Li H, Lu C.

Mol Med Rep. 2017 Mar 30. doi: 10.3892/mmr.2017.6410. [Epub ahead of print]

PMID:

 

28358424

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  1. TCF21 rs12190287 Polymorphisms Are Associated with Ventricular Septal Defects in a Chinese Population.

Yang L, Gao X, Luo H, Huang Q, Su D, Tan X, Lu C.

Genet Test Mol Biomarkers. 2017 Mar 27. doi: 10.1089/gtmb.2016.0324. [Epub ahead of print]

PMID:

 

28346832

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  1. Electronic STIC improves four-dimensional fetal echocardiography.

Guasina F, Bellussi F, Morganelli G, Salsi G, Pilu G, Simonazzi G.

Ultrasound Obstet Gynecol. 2017 Mar 24. doi: 10.1002/uog.17474. [Epub ahead of print]

PMID:

 

28337810

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  1. Point mutations in murine <i>Nkx2-5</i> phenocopy humancongenital heart diseaseand induce pathogenic Wnt signaling.

Furtado MB, Wilmanns JC, Chandran A, Perera J, Hon O, Biben C, Willow TJ, Nim HT, Kaur G, Simonds S, Wu Q, Willians D, Salimova E, Plachta N, Denegre JM, Murray SA, Fatkin D, Cowley M, Pearson JT, Kaye D, Ramialison M, Harvey RP, Rosenthal NA, Costa MW.

JCI Insight. 2017 Mar 23;2(6):e88271. doi: 10.1172/jci.insight.88271.

PMID:

 

28352650

Free PMC Article

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Select item 28344652 102.

 

  1. Cardiac Regeneration: Lessons From Development.

Galdos FX, Guo Y, Paige SL, VanDusen NJ, Wu SM, Pu WT.

Circ Res. 2017 Mar 17;120(6):941-959. doi: 10.1161/CIRCRESAHA.116.309040.

PMID:

 

28302741

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Select item 28302740 123.

 

  1. Genetics and Genomics ofCongenital Heart Disease.

Zaidi S, Brueckner M.

Circ Res. 2017 Mar 17;120(6):923-940. doi: 10.1161/CIRCRESAHA.116.309140.

PMID:

 

28302740

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Select item 28302739 124.

 

  1. Prenatal Diagnosis of the Criss-CrossHeart.

Ravi P, Fruitman D, Mills L, Colen T, Hornberger LK.

Am J Cardiol. 2017 Mar 15;119(6):916-922. doi: 10.1016/j.amjcard.2016.11.046. Epub 2016 Dec 18.

PMID:

 

28215417

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Select item 28087052 141.

 

  1. Does First-Trimester Screening Modify the Natural History ofCongenital Heart Disease? Analysis of Outcome of Regional Cardiac Screening at 2 Different Time Periods.

Jicinska H, Vlasin P, Jicinsky M, Grochova I, Tomek V, Volaufova J, Skovranek J, Marek J.

Circulation. 2017 Mar 14;135(11):1045-1055. doi: 10.1161/CIRCULATIONAHA.115.020864. Epub 2017 Jan 31.

PMID:

 

28143885

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  1. Concordance of fetal echocardiography in the diagnosis ofcongenitalcardiac diseaseutilizing updated guidelines.

Aguilera M, Dummer K.

J Matern Fetal Neonatal Med. 2017 Mar 12:1-6. doi: 10.1080/14767058.2017.1297791. [Epub ahead of print]

PMID:

 

28277918

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  1. Role of HDLive in Imaging the FetalHeart.

Lakshmy SR, Jain B, Rose N.

J Ultrasound Med. 2017 Mar 11. doi: 10.7863/ultra.16.05071. [Epub ahead of print]

PMID:

 

28295440

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  1. Placental Characteristics of Fetuses WithCongenital Heart Disease.

Albalawi A, Brancusi F, Askin F, Ehsanipoor R, Wang J, Burd I, Sekar P.

J Ultrasound Med. 2017 Mar 4. doi: 10.7863/ultra.16.04023. [Epub ahead of print]

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28258617

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  1. Prenatal Diagnosis of a Retroesophageal Left Brachiocephalic Vein: Two Case Reports.

Cheng YK, Law KM, Chak PK, To KF, Chan YM, Leung TY.

J Ultrasound Med. 2017 Mar 4. doi: 10.7863/ultra.16.05003. [Epub ahead of print]

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28258609

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  1. A case of prenatally detected left isomerism and hemiazygos continuation of inferior vena cava.

Moradi B, Moosavi NS, Kazemi MA, Tahmasebpour AR, Fattahi Masrour F.

J Clin Ultrasound. 2017 Mar 3. doi: 10.1002/jcu.22464. [Epub ahead of print]

PMID:

 

28256002

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  1. MicroRNA-1 upregulation promotes myocardiocyte proliferation and suppresses apoptosis duringheartdevelopment.

Liu L, Yuan Y, He X, Xia X, Mo X.

Mol Med Rep. 2017 Mar 3. doi: 10.3892/mmr.2017.6282. [Epub ahead of print]

PMID:

 

28260051

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  1. Blood flow patterns underlie developmentalheartdefects.

Midgett M, Thornburg K, Rugonyi S.

Am J Physiol Heart Circ Physiol. 2017 Mar 1;312(3):H632-H642. doi: 10.1152/ajpheart.00641.2016. Epub 2017 Jan 6.

PMID:

 

28062416

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  1. Notch-Tnf signalling is required for development and homeostasis of arterial valves.

Wang Y, Wu B, Farrar E, Lui W, Lu P, Zhang D, Alfieri CM, Mao K, Chu M, Yang D, Xu D, Rauchman M, Taylor V, Conway SJ, Yutzey KE, Butcher JT, Zhou B.

Eur Heart J. 2017 Mar 1;38(9):675-686. doi: 10.1093/eurheartj/ehv520.

PMID:

 

26491108

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  1. Fetal echocardiography for early detection ofcongenitalheart diseases.

Chitra N, Vijayalakshmi IB.

J Echocardiogr. 2017 Mar;15(1):13-17. doi: 10.1007/s12574-016-0308-2. Epub 2016 Aug 16.

PMID:

 

27530200

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  1. The Fetus with Ectopia Cordis: Experience and Expectations from Two Centers.

Escobar-Diaz MC, Sunderji S, Tworetzky W, Moon-Grady AJ.

Pediatr Cardiol. 2017 Mar;38(3):531-538. doi: 10.1007/s00246-016-1545-x. Epub 2016 Dec 19.

PMID:

 

27995289

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  1. HAND1 Loss-of-Function Mutation Causes Tetralogy of Fallot.

Wang J, Hu XQ, Guo YH, Gu JY, Xu JH, Li YJ, Li N, Yang XX, Yang YQ.

Pediatr Cardiol. 2017 Mar;38(3):547-557. doi: 10.1007/s00246-016-1547-8. Epub 2016 Dec 10.

PMID:

 

27942761

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  1. Longitudinal changes in fetal biometry and cerebroplacental hemodynamics in fetuses withcongenital heart disease.

Ruiz A, Cruz-Lemini M, Masoller N, Sanz-Cortés M, Ferrer Q, Ribera I, Martínez JM, Crispi F, Arévalo S, Gómez O, Pérez-Hoyos S, Carreras E, Gratacós E, Llurba E.

Ultrasound Obstet Gynecol. 2017 Mar;49(3):379-386. doi: 10.1002/uog.15970.

PMID:

 

27214694

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  1. Fetal left-sided cardiac structural dimensions in left-sided congenital diaphragmatic hernia – association with severity and impact on postnatal outcomes.

Kailin J, Dhillon G, Maskatia S, Cass D, Shamshirsaz A, Mehollin-Ray A, Cassady C, Ayres N, Wang Y, Belfort M, Olutoye O, Ruano R.

Prenat Diagn. 2017 Mar 31. doi: 10.1002/pd.5045. [Epub ahead of print]

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28370263

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  1. Counseling Practices for Fetal Hypoplastic Left Heart Syndrome.

Walsh MJ, Verghese GR, Ferguson ME, Fino NF, Goldberg DJ, Owens ST, Pinto N, Zyblewski SC, Quartermain MD.

Pediatr Cardiol. 2017 Mar 27. doi: 10.1007/s00246-017-1601-1. [Epub ahead of print]

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28345115

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  1. Assessment of Cardiac Function in Fetuses of Gestational Diabetic Mothers During the Second Trimester.

Atiq M, Ikram A, Hussain BM, Saleem B.

Pediatr Cardiol. 2017 Mar 24. doi: 10.1007/s00246-017-1600-2. [Epub ahead of print]

PMID:

 

28337515

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  1. Microarray Analysis of Differential Gene Expression Profile Between Human Fetal and Adult Heart.

Geng Z, Wang J, Pan L, Li M, Zhang J, Cai X, Chu M.

Pediatr Cardiol. 2017 Mar 22. doi: 10.1007/s00246-017-1569-x. [Epub ahead of print]

PMID:

 

28331934

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  1. Motion compensated cine CMR of the fetal heart using radial undersampling and compressed sensing.

Roy CW, Seed M, Kingdom JC, Macgowan CK.

J Cardiovasc Magn Reson. 2017 Mar 20;19(1):29. doi: 10.1186/s12968-017-0346-6.

PMID:

 

28316282

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  1. Prenatal diagnosis of aortopulmonary window associated with aberrant subclavian artery.

Louis-Jacques AF, Obican S, Nguyen T, Odibo A.

Cardiol Young. 2017 Mar 16:1-3. doi: 10.1017/S104795111700035X. [Epub ahead of print]

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28300009

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  1. Concordance of fetal echocardiography in the diagnosis of congenital cardiac disease utilizing updated guidelines.

Aguilera M, Dummer K.

J Matern Fetal Neonatal Med. 2017 Mar 12:1-6. doi: 10.1080/14767058.2017.1297791. [Epub ahead of print]

PMID:

 

28277918

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  1. Developmental considerations with regard to so-called absence of the leaflets of the arterial valves.

Tretter JT, Steffensen T, Westover T, Anderson RH, Spicer DE.

Cardiol Young. 2017 Mar;27(2):302-311. doi: 10.1017/S1047951116000524. Epub 2016 Apr 29.

PMID:

 

27125520

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  1. Development of the atrial septum in relation to postnatal anatomy and interatrial communications.

Jensen B, Spicer DE, Sheppard MN, Anderson RH.

Heart. 2017 Mar;103(6):456-462. doi: 10.1136/heartjnl-2016-310660. Epub 2016 Dec 21. Review.

PMID:

 

28003417

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  1. Symptomatic Fetal-Type Cardiac Rhabdomyoma.

Kayali S, Dogan V, Arda NL, Koç M, Ertugrul I, Özgür S, Örün UA, Karademir S.

J Coll Physicians Surg Pak. 2017 Mar;27(3):S53-S55.

PMID:

 

28302247

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  1. Uhl’s anomaly: perspective of fetal echocardiography and histopathological correlation.

Dixon DB, Mackey-Bojack SM, Sivanandam S.

Cardiol Young. 2017 Mar;27(2):388-390. doi: 10.1017/S1047951116001232.

PMID:

 

28366185

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  1. The neurodevelopmental implications of hypoplastic left heart syndrome in the fetus.

Lloyd DF, Rutherford MA, Simpson JM, Razavi R.

Cardiol Young. 2017 Mar;27(2):217-223. doi: 10.1017/S1047951116001645. Epub 2016 Nov 8.

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27821206

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CHD Surgery Featured Articles of March 2017

CHD Surgery March 2017

 

  1. Acute kidney injury and fluid overload in infants and children after cardiac surgery.

Kwiatkowski DM, Krawczeski CD.

Pediatr Nephrol. 2017 Mar 30. doi: 10.1007/s00467-017-3643-2. [Epub ahead of print]

PMID:

 

28361230

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  1. Significant survival advantage of high pulmonary vein index and the presence of native pulmonary artery in pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteries: results from preoperative computed tomography angiography.

Jia Q, Cen J, Zhuang J, Zhong X, Liu X, Li J, Liang C, Huang M.

Eur J Cardiothorac Surg. 2017 Mar 28. doi: 10.1093/ejcts/ezx064. [Epub ahead of print]

PMID:

 

28369397

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  1. National trends and variability in blood utilization in paediatric cardiac surgery.

Karimi M, Sullivan JM, Lerer T, Hronek C.

Interact Cardiovasc Thorac Surg. 2017 Mar 28. doi: 10.1093/icvts/ivw439. [Epub ahead of print]

PMID:

 

28369475

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Select item 28335833 91.

 

  1. Dehiscence of a pulmonary bioprosthesis with a focal dissection of the pulmonary artery in a patient withcongenitalpulmonic stenosis.

Yucel E, Bhatt A, Mihos CG, Ghoshhajra BB, DeFaria Yeh D.

Echocardiography. 2017 Mar 27. doi: 10.1111/echo.13502. [Epub ahead of print]

PMID:

 

28345243

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  1. Surgical planning for a complex double-outlet right ventricle using 3D printing.

Bhatla P, Tretter JT, Chikkabyrappa S, Chakravarti S, Mosca RS.

Echocardiography. 2017 Mar 19. doi: 10.1111/echo.13512. [Epub ahead of print]

PMID:

 

28317159

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  1. Near-infrared spectroscopy as a predictor of clinical deterioration: a case report of two infants with duct-dependentcongenital heart disease.

Mebius MJ, Sarvaas GJ, Wolthuis DW, Bartelds B, Kneyber MC, Bos AF, Kooi EM.

BMC Pediatr. 2017 Mar 16;17(1):79. doi: 10.1186/s12887-017-0839-3.

PMID:

 

28302079

Free PMC Article

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  1. Anesthesia in adults withcongenital heart disease.

Baehner T, Ellerkmann RK.

Curr Opin Anaesthesiol. 2017 Mar 16. doi: 10.1097/ACO.0000000000000468. [Epub ahead of print]

PMID:

 

28306681

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  1. Incorporating Comorbidity Within Risk Adjustment for UK Pediatric Cardiac Surgery.

Brown KL, Rogers L, Barron DJ, Tsang V, Anderson D, Tibby S, Witter T, Stickley J, Crowe S, English K, Franklin RC, Pagel C.

Ann Thorac Surg. 2017 Mar 15. pii: S0003-4975(16)31826-4. doi: 10.1016/j.athoracsur.2016.12.013. [Epub ahead of print]

PMID:

 

28318514

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  1. Improving Risk Adjustment for Mortality After Pediatric Cardiac Surgery: The UK PRAiS2 Model.

Rogers L, Brown KL, Franklin RC, Ambler G, Anderson D, Barron DJ, Crowe S, English K, Stickley J, Tibby S, Tsang V, Utley M, Witter T, Pagel C.

Ann Thorac Surg. 2017 Mar 15. pii: S0003-4975(16)31828-8. doi: 10.1016/j.athoracsur.2016.12.014. [Epub ahead of print]

PMID:

 

28318513

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  1. Mechanical and microstructural analysis of a radially expandable vascular conduit for neonatal and pediatric cardiovascular surgery.

Loneker AE, Luketich SK, Bernstein D, Kalra A, Nugent AW, D’Amore A, Faulk DM.

J Biomed Mater Res B Appl Biomater. 2017 Mar 10. doi: 10.1002/jbm.b.33874. [Epub ahead of print]

PMID:

 

28296198

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  1. Decellularized Cryopreserved Allografts as Off-the-Shelf Allogeneic Alternative forHeartValve Replacement: In Vitro Assessment Before Clinical Translation.

Iop L, Paolin A, Aguiari P, Trojan D, Cogliati E, Gerosa G.

J Cardiovasc Transl Res. 2017 Mar 9. doi: 10.1007/s12265-017-9738-0. [Epub ahead of print]

PMID:

 

28281241

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  1. Translational Challenges in Cardiovascular Tissue Engineering.

Emmert MY, Fioretta ES, Hoerstrup SP.

J Cardiovasc Transl Res. 2017 Mar 9. doi: 10.1007/s12265-017-9728-2. [Epub ahead of print]

PMID:

 

28281240

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  1. Single coronary artery and neonatal arterial switch operation: early and long-term outcomes†.

Gerelli S, Pontailler M, Rochas B, Angeli E, Van Steenberghe M, Bonnet D, Vouhé P, Raisky O.

Eur J Cardiothorac Surg. 2017 Mar 7. doi: 10.1093/ejcts/ezx046. [Epub ahead of print]

PMID:

 

28329313

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  1. Contemporary cardiac surgery for adults withcongenital heart disease.

Beurtheret S, Tutarel O, Diller GP, West C, Ntalarizou E, Resseguier N, Papaioannou V, Jabbour R, Simpkin V, Bastin AJ, Babu-Narayan SV, Bonello B, Li W, Sethia B, Uemura H, Gatzoulis MA, Shore D.

Heart. 2017 Mar 7. pii: heartjnl-2016-310384. doi: 10.1136/heartjnl-2016-310384. [Epub ahead of print]

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28270427

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  1. Outcomes following implantation of mechanical circulatory support in adults withcongenital heart disease: An analysis of the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS).

VanderPluym CJ, Cedars A, Eghtesady P, Maxwell BG, Gelow JM, Burchill LJ, Maltais S, Koehl DA, Cantor RS, Blume ED.

Heart Lung Transplant. 2017 Mar 7. pii: S1053-2498(17)31682-0. doi: 10.1016/j.healun.2017.03.005. [Epub ahead of print]

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28365175

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  1. Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients undergoing surgery forcongenital heart disease.

Hummel J, Rücker G, Stiller B.

Cochrane Database Syst Rev. 2017 Mar 6;3:CD011312. doi: 10.1002/14651858.CD011312.pub2. Review.

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  1. Popular HybridCongenitalHeart Procedures without Cardiopulmonary Bypass.

Gupta A, Amin Z.

Front Surg. 2017 Mar 6;4:9. doi: 10.3389/fsurg.2017.00009. eCollection 2017. Review.

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  1. Long-term survival after the Fontan operation: Twenty years of experience at a single center.

Downing TE, Allen KY, Glatz AC, Rogers LS, Ravishankar C, Rychik J, Faerber JA, Fuller S, Montenegro LM, Steven JM, Spray TL, Nicolson SC, Gaynor JW, Goldberg DJ.

J Thorac Cardiovasc Surg. 2017 Mar 6. pii: S0022-5223(17)30373-2. doi: 10.1016/j.jtcvs.2017.01.056. [Epub ahead of print]

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  1. Improved long-term outcomes in double-inlet left ventricle and tricuspid atresia with transposed great arteries: systemic outflow tract obstruction present at birth defines long-term outcome.

Franken LC, Admiraal M, Verrall CE, Zannino D, Ayer JG, Iyengar AJ, Cole AD, Sholler GF, D’Udekem Y, Winlaw DS.

Eur J Cardiothorac Surg. 2017 Mar 4. doi: 10.1093/ejcts/ezx022. [Epub ahead of print]

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28329058

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  1. Successful cardiac transplantation outcomes in patients with adultcongenital heart disease.

Menachem JN, Golbus JR, Molina M, Mazurek JA, Hornsby N, Atluri P, Fuller S, Birati EY, Kim YY, Goldberg LR, Wald JW.

Heart. 2017 Mar 3. pii: heartjnl-2016-310933. doi: 10.1136/heartjnl-2016-310933. [Epub ahead of print]

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28258242

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  1. Long-Term Outcome of Patients With Complete Atrioventricular Septal Defect Combined With the Tetralogy of Fallot: Staged Repair Is Not Inferior to Primary Repair.

Vitanova K, Cleuziou J, Schreiber C, Günther T, Pabst von Ohain J, Hörer J, Lange R.

Ann Thorac Surg. 2017 Mar;103(3):876-880. doi: 10.1016/j.athoracsur.2016.07.038. Epub 2016 Sep 28.

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27692233

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  1. Two-dimensional right ventricular strain by speckle tracking for assessment of longitudinal right ventricular function after paediatriccongenital heart diseasesurgery.

Karsenty C, Hadeed K, Dulac Y, Semet F, Alacoque X, Breinig S, Leobon B, Acar P, Hascoet S.

Arch Cardiovasc Dis. 2017 Mar;110(3):157-166. doi: 10.1016/j.acvd.2016.09.003. Epub 2016 Dec 27.

PMID:

 

28034627

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  1. Health-related quality of life in children with surgery for CHD: a study from the Swedish National Registry forCongenital Heart Disease.

Svensson B, Idvall E, Nilsson F, Liuba P.

Cardiol Young. 2017 Mar;27(2):333-343. doi: 10.1017/S1047951116000585. Epub 2016 May 26.

PMID:

 

27225489

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  1. Alterations in antioxidant and oxidant status of children after on-pump surgery for cyanotic and acyanoticcongenitalheart diseases.

Altin FH, Yildirim HA, Tanidir IC, Yildiz O, Kahraman MZ, Ozturk E, Celebi SB, Kyaruzi M, Bakir İ.

Cardiol Young. 2017 Mar;27(2):325-332. doi: 10.1017/S1047951116000573. Epub 2016 May 19.

PMID:

 

27194079

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  1. Clinical significance of serum cortisol levels following surgery forcongenital heart disease.

Teagarden AM, Mastropietro CW.

Cardiol Young. 2017 Mar;27(2):318-324. doi: 10.1017/S104795111600055X. Epub 2016 Apr 29.

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27125662

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  1. Hydrodynamic Assessment of Aortic Valves Prepared from Porcine Small Intestinal Submucosa.

Ramaswamy S, Lordeus M, Mankame OV, Valdes-Cruz L, Bibevski S, Bell SM, Baez I, Scholl F.

Cardiovasc Eng Technol. 2017 Mar;8(1):30-40. doi: 10.1007/s13239-016-0290-x. Epub 2016 Dec 19.

PMID:

 

27995570

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  1. Single-center outcomes of combinedheartand liver transplantation in the failing Fontan.

D’Souza BA, Fuller S, Gleason LP, Hornsby N, Wald J, Krok K, Shaked A, Goldberg LR, Pochettino A, Olthoff KM, Kim YY.

Clin Transplant. 2017 Mar;31(3). doi: 10.1111/ctr.12892. Epub 2017 Feb 4.

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27988989

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  1. Decreased biventricular longitudinal strain shortly aftercongenitalheart defect surgery.

de Boer JM, Kuipers IM, Klitsie LM, Blom NA, Ten Harkel AD.

Echocardiography. 2017 Mar;34(3):446-452. doi: 10.1111/echo.13456. Epub 2017 Feb 6.

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28168740

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  1. Systemic right ventricular morphology in the early postoperative course after extracardiac Fontan operation: is there still a need for special care?

Nordmeyer S, Rohder M, Nordmeyer J, Miera O, Peters B, Cho MY, Photiadis J, Berger F, Ovroutski S.

Eur J Cardiothorac Surg. 2017 Mar 1;51(3):483-489. doi: 10.1093/ejcts/ezw374.

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  1. Glial fibrillary acidic protein plasma levels are correlated with degree of hypothermia during cardiopulmonary bypass incongenital heart diseasesurgery.

Vedovelli L, Padalino M, D’Aronco S, Stellin G, Ori C, Carnielli VP, Simonato M, Cogo P.

Interact Cardiovasc Thorac Surg. 2017 Mar 1;24(3):436-442. doi: 10.1093/icvts/ivw395.

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28040762

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  1. Surgical management of double outlet right ventricle with aortopulmonary window.

Hou C, Sihag V, Ling Y, An Q.

J Card Surg. 2017 Mar;32(3):203-205. doi: 10.1111/jocs.13102.

PMID:

 

28247470

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  1. Extubation Failure after Neonatal Cardiac Surgery: A Multicenter Analysis.

Mastropietro CW, Cashen K, Grimaldi LM, Narayana Gowda KM, Piggott KD, Wilhelm M, Gradidge E, Moser EA, Benneyworth BD, Costello JM.

J Pediatr. 2017 Mar;182:190-196.e4. doi: 10.1016/j.jpeds.2016.12.028. Epub 2017 Jan 4.

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  1. Gastrointestinal complications associated with the surgical treatment ofheartdiseasein children.

Ferguson LP, Gandiya T, Kaselas C, Sheth J, Hasan A, Gabra HO.

J Pediatr Surg. 2017 Mar;52(3):414-419. doi: 10.1016/j.jpedsurg.2016.10.052. Epub 2016 Nov 14.

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27916446

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  1. The impact of cardiac risk factors on short-term outcomes for children undergoing a Ladd procedure.

Putnam LR, Anderson KT, Tsao K, Kao LS, Lugo JA, Lally KP, Kawaguchi AL.

J Pediatr Surg. 2017 Mar;52(3):390-394. doi: 10.1016/j.jpedsurg.2016.09.064. Epub 2016 Oct 21.

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  1. Natural history of nonimmune-mediated thrombocytopenia and acute kidney injury in pediatric open-heartsurgery.

Tew S, Fontes ML, Greene NH, Kertai MD, Ofori-Amanfo G, Jaquiss RD, Lodge AJ, Ames WA, Homi HM, Machovec KA, Jooste EH.

Paediatr Anaesth. 2017 Mar;27(3):305-313. doi: 10.1111/pan.13063. Epub 2017 Jan 18.

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28098429

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  1. Prevalence and Risk Factors for Pericardial Effusions Requiring Readmission After Pediatric Cardiac Surgery.

Elias MD, Glatz AC, O’Connor MJ, Schachtner S, Ravishankar C, Mascio CE, Cohen MS.

Pediatr Cardiol. 2017 Mar;38(3):484-494. doi: 10.1007/s00246-016-1540-2. Epub 2016 Nov 30.

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27900408

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  1. Perioperative Near-Infrared Spectroscopy Monitoring in Neonates WithCongenital Heart Disease: Relationship of Cerebral Tissue Oxygenation Index Variability With Neurodevelopmental Outcome.

Spaeder MC, Klugman D, Skurow-Todd K, Glass P, Jonas RA, Donofrio MT.

Pediatr Crit Care Med. 2017 Mar;18(3):213-218. doi: 10.1097/PCC.0000000000001056.

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28067688

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  1. Left Ventricular Retraining and Double Switch in Patients With Congenitally Corrected Transposition of the Great Arteries.

Ibrahimiye AN, Mainwaring RD, Patrick WL, Downey L, Yarlagadda V, Hanley FL.

World J Pediatr Congenit Heart Surg. 2017 Mar;8(2):203-209. doi: 10.1177/2150135116683939.

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28329464

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  1. Nineteen Years of AdultCongenitalHeart Surgery in a Single Center.

Perinpanayagam M, Larsen SH, Emmertsen K, Møller MB, Hjortdal VE.

World J Pediatr Congenit Heart Surg. 2017 Mar;8(2):182-188. doi: 10.1177/2150135116682454.

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28329459

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  1. Hemolysis During Open-HeartSurgery With Vacuum-Assisted Venous Drainage at Different Negative Pressures in Pediatric Patients Weighing Less Than 10 kilograms.

Kwak JG, Lee J, Park M, Seo YJ, Lee CH.

World J Pediatr Congenit Heart Surg. 2017 Mar;8(2):161-165. doi: 10.1177/2150135116681734.

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  1. Anomalous Pulmonary Venous Connection With an Intraparenchymal Course.

Campanale CM, Banka P, Sanders SP.

World J Pediatr Congenit Heart Surg. 2017 Mar;8(2):210-214. doi: 10.1177/2150135116682468. Epub 2016 Dec 30.

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28036230

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  1. Superior Vena Cava Banding to Facilitate Unilateral Bidirectional Glenn Operation in Patients With Single VentricleHeartDisease and Bilateral Superior Caval Veins.

Schwartz MC, Nykanen D, DeCampli W, Pourmoghadam K.

World J Pediatr Congenit Heart Surg. 2017 Mar;8(2):215-219. doi: 10.1177/2150135116679824. Epub 2016 Dec 7.

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  1. Survival of Three Neonates WithCongenitalDiaphragmatic Hernia and d-Transposition of the Great Arteries.

Blancha VL, Ratner V, Aspelund G, Chai P, Levasseur S, Krishnan U, Bacha E, Krishnamurthy G.

World J Pediatr Congenit Heart Surg. 2017 Mar;8(2):239-241. doi: 10.1177/2150135116632509. Epub 2016 Jul 7.

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  1. Endoventriculoplasty of the Left Ventricle forCongenitalDiverticulum.

Soynov IA, Sinelnikov YS, Nichay NR, Omelchenko AY, Kornilov IA.

World J Pediatr Congenit Heart Surg. 2017 Mar;8(2):227-230. doi: 10.1177/2150135115625204. Epub 2016 Jul 8.

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  1. Acute kidney injury and fluid overload in infants and children after cardiac surgery.

Kwiatkowski DM, Krawczeski CD.

Pediatr Nephrol. 2017 Mar 30. doi: 10.1007/s00467-017-3643-2. [Epub ahead of print]

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28361230

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  1. An Alternative Strategy for Bridge-to-Transplant/Recovery in Small Children with Dilated Cardiomyopathy.

Mets G, Panzer J, De Wolf D, Bové T.

Pediatr Cardiol. 2017 Mar 29. doi: 10.1007/s00246-017-1610-0. [Epub ahead of print] Review.

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28357450

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  1. Reducing PediatricSternal Wound Infections: A Quality Improvement Project.

Delgado-Corcoran C, Van Dorn CS, Pribble C, Thorell EA, Pavia AT, Ward C, Smout R, Bratton SL, Burch PT.

Pediatr Crit Care Med. 2017 Mar 27. doi: 10.1097/PCC.0000000000001135. [Epub ahead of print]

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28350561

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  1. Interstage Weight Gain Is Associated With Survival After First-Stage Single-Ventricle Palliation.

Evans CF, Sorkin JD, Abraham DS, Wehman B, Kaushal S, Rosenthal GL.

Ann Thorac Surg. 2017 Mar 24. pii: S0003-4975(16)31889-6. doi: 10.1016/j.athoracsur.2016.12.031. [Epub ahead of print]

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  1. Hypoplastic Left Heart Syndrome is not Associated with Worse Clinical or Neurodevelopmental Outcomes Than Other Cardiac Pathologies After the Norwood-Sano Operation.

Martin BJ, De Villiers Jonker I, Joffe AR, Bond GY, Acton BV, Ross DB, Robertson CM, Rebeyka IM, Atallah J.

Pediatr Cardiol. 2017 Mar 24. doi: 10.1007/s00246-017-1598-5. [Epub ahead of print]

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28341901

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  1. The Effects of Center Volume on Mortality in PediatricHeart Transplantation- The Rest of the Story.

Canter CE.

Am J Transplant. 2017 Mar 23. doi: 10.1111/ajt.14277. [Epub ahead of print]

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28332766

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  1. Concomitant pulsatile and continuous flow VAD in biventricular and univentricular physiology: a comparison study with a numerical model.

Di Molfetta A, Ferrari G, Iacobelli R, Filippelli S, Guccione P, Fresiello L, Perri G, Amodeo A.

Int J Artif Organs. 2017 Mar 16;40(2):74-81. doi: 10.5301/ijao.5000562. Epub 2017 Feb 11.

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28218352

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  1. Gothic aortic arch and cardiac mechanics in young patients after arterial switch operation for d-transposition of the great arteries.

Di Salvo G, Bulbul Z, Pergola V, Issa Z, Siblini G, Muhanna N, Galzerano D, Fadel B, Al Joufan M, Al Fayyadh M, Al Halees Z.

Int J Cardiol. 2017 Mar 11. pii: S0167-5273(17)30958-0. doi: 10.1016/j.ijcard.2017.03.044. [Epub ahead of print]

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28325614

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  1. Implications and outcomes of cardiac grafts refused by pediatriccenters but transplanted by adult centers.

Zafar F, Rizwan R, Lorts A, Bryant R 3rd, Tweddell JS, Chin C, Morales DL.

J Thorac Cardiovasc Surg. 2017 Mar 11. pii: S0022-5223(17)30413-0. doi: 10.1016/j.jtcvs.2016.12.071. [Epub ahead of print]

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28366553

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  1. Feasibility and interpretation of global longitudinal strain imaging in pediatricheart transplant recipients.

Wisotzkey BL, Jorgensen NW, Albers EL, Kemna MS, Boucek RJ, Kronmal RA, Law YM, Bhat AH.

Pediatr Transplant. 2017 Mar 10. doi: 10.1111/petr.12909. [Epub ahead of print]

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28295946

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  1. Biventricular impact of mild to moderate pulmonary valve stenosis in fetal life.

Guirado L, Crispi F, Masoller N, Bennasar M, Marimon E, Carretero J, Gratacós E, Martínez JM, Friedberg MK, Gómez O.

Ultrasound Obstet Gynecol. 2017 Mar 10. doi: 10.1002/uog.17456. [Epub ahead of print]

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28295792

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  1. Impact of Heart Transplantation on the Functional Status of US Children With End-Stage Heart Failure.

Peng DM, Zhang Y, Rosenthal DN, Palmon M, Chen S, Kaufman BD, Maeda K, Hollander SA, McDonald N, Smoot LB, Bernstein D, Almond CS.

Circulation. 2017 Mar 7;135(10):939-950. doi: 10.1161/CIRCULATIONAHA.115.016520. Epub 2017 Jan 24.

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28119383

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  1. Importance of multidisciplinary management for pulmonary atresia, ventricular septal defect, major aorto-pulmonary collateral arteries and completely absent central pulmonary arteries.

Hoashi T, Yazaki S, Kagisaki K, Kitano M, Shimada M, Shiraishi I, Ichikawa H.

Gen Thorac Cardiovasc Surg. 2017 Mar 4. doi: 10.1007/s11748-017-0765-1. [Epub ahead of print]

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28260150

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  1. Dynamic Changes in Aortic Vascular Stiffness in Patients Bridged to Transplant With Continuous-Flow Left Ventricular Assist Devices.

Patel AC, Dodson RB, Cornwell WK 3rd, Hunter KS, Cleveland JC Jr, Brieke A, Lindenfeld J, Ambardekar AV.

JACC Heart Fail. 2017 Mar 4. pii: S2213-1779(17)30046-X. doi: 10.1016/j.jchf.2016.12.009. [Epub ahead of print]

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28285118

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  1. Femoral Vein Homograft as Right Ventricle to Pulmonary Artery Conduit in Stage 1 Norwood Operation.

Kumar TK, Briceno-Medina M, Sathanandam S, Joshi VM, Knott-Craig CJ.

Ann Thorac Surg. 2017 Mar 2. pii: S0003-4975(16)31819-7. doi: 10.1016/j.athoracsur.2016.11.078. [Epub ahead of print]

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28262297

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  1. Functional status of United States children supported with a left ventricular assist device at heart transplantation.

Bulic A, Maeda K, Zhang Y, Chen S, McElhinney DB, Dykes JC, Hollander AM, Hollander SA, Murray J, Reinhartz O, Gowan MA, Rosenthal DN, Almond CS.

J Heart Lung Transplant. 2017 Mar 2. pii: S1053-2498(17)31675-3. doi: 10.1016/j.healun.2017.02.024. [Epub ahead of print]

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28363739

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  1. Genomic Contraindications for Heart Transplantation.

Char DS, Lázaro-Muñoz G, Barnes A, Magnus D, Deem MJ, Lantos JD.

Pediatrics. 2017 Mar 2. pii: e20163471. doi: 10.1542/peds.2016-3471. [Epub ahead of print]

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28255068

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  1. Inferior Outcomes on the Waiting List in Low-Volume PediatricHeart Transplant Centers.

Rana A, Fraser CD, Scully BB, Heinle JS, McKenzie ED, Dreyer WJ, Kueht M, Liu H, Brewer ED, Rosengart TK, O’Mahony CA, Goss JA.

Am J Transplant. 2017 Mar 1. doi: 10.1111/ajt.14252. [Epub ahead of print]

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28251816

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  1. The Role of Echocardiography and Intracardiac Exploration in the Evaluation of Candidacy for Biventricular Repair in Patients With Borderline Left Heart Structures.

Mery CM, Nieto RM, De León LE, Morris SA, Zhang W, Colquitt JL, Adachi I, Kane LC, Heinle JS, McKenzie ED, Fraser CD Jr.

Ann Thorac Surg. 2017 Mar;103(3):853-861. doi: 10.1016/j.athoracsur.2016.07.043. Epub 2016 Oct 4.

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27717424

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  1. Neonatal Ebstein repair-where are we now?

Wackel PL, Dearani JA, Cetta F.

Ann Transl Med. 2017 Mar;5(5):109. doi: 10.21037/atm.2017.01.19. No abstract available.

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28361074

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  1. Application of a Lumped Parameter Model to Study the Feasibility of Simultaneous Implantation of a Continuous Flow Ventricular Assist Device (VAD) and a Pulsatile Flow VAD in BIVAD Patients.

Di Molfetta A, Ferrari G, Iacobelli R, Filippelli S, Fresiello L, Guccione P, Toscano A, Amodeo A.

Artif Organs. 2017 Mar;41(3):242-252. doi: 10.1111/aor.12911.

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28281287

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  1. Pediatricheart transplant for unresectable primary cardiac tumor.

Prakash Rajakumar A, Ejaz Ahmed S, Varghese R, Kothandam S, Murmu UC, Sethuratnam R.

Asian Cardiovasc Thorac Ann. 2017 Mar;25(3):207-209. doi: 10.1177/0218492315614160. Epub 2016 Jul 11.

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26542780

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  1. Anomalous left coronary artery from the pulmonary artery discovered following total anomalous pulmonary venous return repair: a rare entity.

Patel ND, Badran S, Kung G.

Cardiol Young. 2017 Mar;27(2):385-387. doi: 10.1017/S1047951116001220. Epub 2016 Aug 30.

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27573031

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  1. Health-related quality of life in children with surgery for CHD: a study from the Swedish National Registry for Congenital Heart Disease.

Svensson B, Idvall E, Nilsson F, Liuba P.

Cardiol Young. 2017 Mar;27(2):333-343. doi: 10.1017/S1047951116000585. Epub 2016 May 26.

PMID:

 

27225489

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  1. Alterations in antioxidant and oxidant status of children after on-pump surgery for cyanotic and acyanotic congenital heart diseases.

Altin FH, Yildirim HA, Tanidir IC, Yildiz O, Kahraman MZ, Ozturk E, Celebi SB, Kyaruzi M, Bakir İ.

Cardiol Young. 2017 Mar;27(2):325-332. doi: 10.1017/S1047951116000573. Epub 2016 May 19.

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27194079

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  1. Early and late outcomes after surgical management of congenital vascular rings.

François K, Panzer J, De Groote K, Vandekerckhove K, De Wolf D, De Wilde H, Marchau F, De Caluwe W, Benatar A, Bové T.

Eur J Pediatr. 2017 Mar;176(3):371-377. doi: 10.1007/s00431-017-2850-y. Epub 2017 Jan 13.

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28091779

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  1. Erratum to: Impact of varied center volume categories on volume-outcome relationship in children receiving ECMO for heart operations.

Rettiganti M, Seib PM, Robertson MJ, Wilcox A, Gupta P.

J Artif Organs. 2017 Mar;20(1):102. doi: 10.1007/s10047-016-0934-5. No abstract available.

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27909838

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  1. Left ventricular assist device as destination therapy in cardiac end-stage dystrophinopathies: Midterm results.

Perri G, Filippelli S, Adorisio R, Iacobelli R, Iodice F, Testa G, Paglietti MG, D’Amario D, Massetti M, Amodeo A.

J Thorac Cardiovasc Surg. 2017 Mar;153(3):669-674. doi: 10.1016/j.jtcvs.2016.08.016. Epub 2016 Aug 28.

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  1. Institution of Veno-arterial Extracorporeal Membrane Oxygenation Does Not Lead to Increased Wall Stress in Patients with Impaired Myocardial Function.

Koth AM, Axelrod DM, Reddy S, Roth SJ, Tacy TA, Punn R.

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  1. Right Ventricular Dysfunction as an Echocardiographic Measure of Acute Rejection Following Heart Transplantation in Children.

Aggarwal S, Blake J, Sehgal S.

Pediatr Cardiol. 2017 Mar;38(3):442-447. doi: 10.1007/s00246-016-1533-1. Epub 2016 Nov 23.

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27878627

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  1. Central Venous to Arterial CO2 Difference After Cardiac Surgery in Infants and Neonates.

Rhodes LA, Erwin WC, Borasino S, Cleveland DC, Alten JA.

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  1. Heart transplantation in children with intellectual disability.

Hollander SA.

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28191754

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  1. Autoimmune enteropathy and hepatitis in pediatricheart transplant recipient.

Lewis K, Butts R, Antonio Quiros J, Hudspeth M, Twombley K, Savage A, Self S, Burnette A, Sun S.

Pediatr Transplant. 2017 Mar;21(2). doi: 10.1111/petr.12877. Epub 2017 Jan 17.

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28097735

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  1. Heart transplantation in children with intellectual disability: An analysis of the UNOS database.

Goel AN, Iyengar A, Schowengerdt K, Fiore AC, Huddleston CB.

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27933693

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  1. Current Practices in the Timing of Stage 2 Palliation.

Meza JM, Jaquiss RD, Anderson BR, Moga MA, Kirklin JK, Sarris G, Williams WG, McCrindle BW; Congenital Heart Surgeons’ Society..

World J Pediatr Congenit Heart Surg. 2017 Mar;8(2):135-141. doi: 10.1177/2150135116677253.

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28329463

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Borodinova O, Ostras O, Raad T, Yemets I.

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27143716

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Nakanishi K, Kawasaki S, Amano A.

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28318481

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  1. Growth of left ventricular outflow tract and predictors of future re-intervention after repair for ventricular septal defect and aortic arch obstruction.

Jijeh A, Ismail M, Alhabshan F.

Cardiol Young. 2017 Mar 16:1-6. doi: 10.1017/S104795111700018X. [Epub ahead of print]

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28300017

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  1. The Total Inotrope Exposure Score: an extension of the Vasoactive Inotrope Score as a predictor of adverse outcomes after paediatric cardiac surgery.

Bangalore H, Gaies M, Ocampo EC, Heinle JS, Guffey D, Minard CG, Checchia P, Shekerdemian LS.

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28287056

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Herrmann JL, Irons ML, Mascio CE, Rychik J, Spray TL, Gaynor JW, Pogoriler JE.

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Pita-Fernández A, González-López MT, Gil-Jaurena JM.

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28260546

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  1. Aortic arch advancement for type A interrupted aortic arch with persistent fifth aortic arch type B.

Binsalamah ZM, Chen P, McKenzie ED.

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  1. An alternative technique for Fontan completion in patients with widely separated connections of the inferior systemic veins to the atrial mass.

Pomè G, Ghedira F, Keizman E.

Cardiol Young. 2017 Mar;27(2):398-401. doi: 10.1017/S1047951116001311. Epub 2016 Aug 30.

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28181900

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  1. Alterations in antioxidant and oxidant status of children after on-pump surgery for cyanotic and acyanotic congenital heart diseases.

Altin FH, Yildirim HA, Tanidir IC, Yildiz O, Kahraman MZ, Ozturk E, Celebi SB, Kyaruzi M, Bakir İ.

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Teagarden AM, Mastropietro CW.

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CHD Intervention Featured Articles of March 2017

 

Interventional Cardiology Featured Reviews of February-March 2017 Publications 

 

Surgical rescue after transcatheter interventional procedures in congenital heart disease patients: an existing problem.

Varrica A, Lo Rito M, Generali T, Satriano A, D’Oria V, Conforti E, Pluchinotta F, Chessa M, Butera G, Frigiola A, Carminati M, Giamberti A.

EuroIntervention. 2017 Feb 20;12(14):1724-1729. doi: 10.4244/EIJ-D-16-00031.

PMID:27773863

Free Article

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Take Home Points:

 

  • Despite improvements in catheterization equipment and techniques, there is still the potential need for surgical intervention after cath-based intervention in immediate and short-term follow-up.
  • This study stresses the importance of the availability of surgical colleagues, particularly during challenging cath-based interventions, as well as long term follow-up to look for future complications.

 Seckler, MikeCommentary from Dr. Michael Seckeler (Tucson), section editor of Congenital Heart Interventions Journal Watch:  Varrica and colleagues present a retrospective review of their single-center experience with interventional cardiac catheterizations and assess the rate of surgical interventions following catheterization. They divided the cases into early complications – during the catheterization or prior to hospital discharge, and late complications – surgery after hospital discharge. Of nearly 7,000intervention media v1

catheterizations during the review period, 3,205 involved an intervention (Table 1). A total of 40 patients (1.2%) required surgical intervention and 55% of interventions were early.

 

Atrial septal defect (ASD) closure required the highest number of surgical interventions, but was also the most commonly performed cath-based intervention. Of the early ASD surgical interventions, 79% were related to device embolization or erosion. The highest need for surgical intervention occurred in the percutaneous pulmonary valve implantation patients – early interventions were for coronary artery compression and device embolization and later interventions were for infective endocarditis involving the implanted valve. Of all late interventions, ASD device complications were the most common cause leading to 72% of surgeries.

Despite the limitation of being a single-center study, the large number of patients and long follow-up period provide additional insight into the risks of cath-based interventions in the current era as well as the importance of continued follow-up after interventions are performed.

Cardiac 3D Printing and its Future Directions.

Vukicevic M, Mosadegh B, Min JK, Little SH.

JACC Cardiovasc Imaging. 2017 Feb;10(2):171-184. doi: 10.1016/j.jcmg.2016.12.001. Review.

PMID: 28183437

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Take Home Points:

 

  • 3-D printing is being increasingly utilized in congenital and structural cardiac interventions.
  • Methods are expanding beyond simple anatomic visualization and now include the potential to physically model and assess hemodynamics in vitro to more accurately guide appropriate interventions and development of new interventional devices.

 

Commentary from Dr. Michael Seckeler (Tucson), section editor of Congenital Heart Interventions Journal Watch:  The authors provide an overview of the available 3-D printing technologies and their different capabilities regarding model resolution and material availability. They also outline the steps of generating a 3-D model from initial image acquisition of a 3-D volumetric dataset (typically CT or MR data),

 

intervention media v2

through image segmentation (the process of highlighting the pertinent anatomical structures), 3-D reconstruction, generating a digital 3-D model and finally printing the physical model.

 

The multiple uses of 3-D printed models that have been developed so far are also presented. These include:

  1. Trainee and patient education, particularly of complex congenital heart defects
  2. Functional flow models which have been used to model aortic stenosis and coronary artery flow
  3. Surgical and catheterization procedural planning, including double outlet right ventricle repair, complex percutaneous pulmonary valve implantation and aortic coarctation stenting
  4. Development of new devices that are more appropriate for human anatomy rather than using animal models

 

They conclude with a discussion of currently available printing materials and their different mechanical properties followed by a review of critical developments in the literature for different aspects of creating 3-D printed models. Importantly, limitations of the currently available technology are presented, including accuracy of mechanical properties of the materials to simulate cardiac muscle and a lack of validation of model accuracy across a variety of generation methods and 3-D printing hardware.

 

Long-term outcomes and re-interventions following balloon aortic valvuloplasty in pediatric patients with congenital aortic stenosis: A single-center study.

Sullivan PM, Rubio AE, Johnston TA, Jones TK.

Catheter Cardiovasc Interv. 2017 Feb 1;89(2):288-296. doi: 10.1002/ccd.26722.

PMID: 27650723

 

Take Home Points:

 

  • BAV is a safe and effective option for patients with AS requiring intervention in the short term.
  • There is a low long-term mortality and need for cardiac transplantation.
  • Moderate-severe AI post-BAV may place patients at higher risk of requiring AVR in the long-term compared to post-BAV AS and may argue for a more conservative strategy in the cath lab.

Commentary from Dr. Konstantin Averin (Edmonton), section editor of Congenital Heart Interventions Journal Watch:  At many centers, balloon aortic valvuloplasty (BAV) has become the procedure of choice for pediatric patients with aortic stenosis requiring intervention. In this paper, the authors report a single center experience with BAV in neonates, infants and children with up to 20 years of follow up. The aims of the study were to: (1) describe the long-term risk of mortality or heart transplantation, significant AI and LVOT re-intervention (i.e. aortic valve replacement); and (2) to identify risk factors for re-interventions on the LVOT.

 

One hundred and fifty-four patients who underwent BAV between 1993 and 2013 were included for analysis with a median follow up of 6.1 years. There were no procedural deaths, 9 total deaths, and 2 patients who underwent heart transplantation at a median of 51 days after the procedure.  At 15 years, post-procedure transplant free survival was 85% in those who underwent BAV as neonates, 94% in those who underwent BAV between 31 days and 1 year and 100% in those who were older than 1 year at time of BAV. 35% of patients underwent at least 1 LVOT intervention, with repeat BAV – 46% and Ross-Konno – 22% being the most common. Only 45% of neonates and 62% of infants and older children were estimated to remain free from AVR 15 years after BAV. On multivariate analysis, neonatal age, additional obstructive left heart lesions (HR 2.7), pre-cath gradient > 80mmHg (HR 2.8), post-gradient > 30mmHg (HR 4.5) and moderate-severe acute AI (2.6) were associated with an elevated risk for LVOT re-intervention. Interestingly, on multi-variate analysis adjusted by year of catheterization the risk of post-BAV AVR was much higher in those with moderate-severe AI (HR 10.4) compared to those with post-BAV AS (HR 3.0).

 

The authors conclude that BAV carries a low long-term risk of mortality but that there is a substantial long-term risk of valve dysfunction and re-intervention (including AVR). The most clinically relevant finding from this paper may be that acute AI is associated with a significantly greater risk of AVR compared to residual AS suggesting that a more conservative approach may be prudent.

 

Cardiac 3D Printing and its Future Directions.

Vukicevic M, Mosadegh B, Min JK, Little SH.

JACC Cardiovasc Imaging. 2017 Feb;10(2):171-184. doi: 10.1016/j.jcmg.2016.12.001. Review.

PMID: 28183437

Similar articles

Clinical evaluation of a radio-protective cream for the hands of the pediatric interventional cardiologist.

Subramanian S, Waller BR, Winders N, Bird LE, Agrawal V, Zurakowski D, Kuhls-Gilcrist A, Khandkar A, Sathanandam SK.

Catheter Cardiovasc Interv. 2017 Mar 1;89(4):709-716. doi: 10.1002/ccd.26845. Epub 2016 Nov 26.

PMID: 27888578

 

Take Home Points:

 

  • Pediatric interventional cardiologists are exposed to increasing amounts of radiation as the complexity and number of pediatric procedures increases.
  • Operators hands are unprotected during procedures.
  • The UltraBloxTM cream provides a new option for radio-protection for the hands of the pediatric interventional cardiologist, offering 40% radiation attenuation.

Commentary from Dr. Konstantin Averin (Edmonton), section editor of Congenital Heart Interventions Journal Watch:  As the complexity of pediatric catheterization procedures increases, providers are exposed to increasing amount ionizing radiation. Operators hands are directly under the primary entrance or exit radiation beams and are typically unprotected. The authors conducted a single center, prospective, controlled clinal study utilizing UltraBloxTM cream, a new FDA approved radiation-attenuation cream. The aims of the study were to: (1) determine the percent reduction of radiation exposure using the cream up to 180 minutes; and (2) determine user comfort and satisfaction with the cream.

 

40 patients were recruited for the study and the procedures were classified into 4 categories (10 each) by procedure duration: 0-30, 31-60, 61-120, and 121-180 minutes. The 4 groups were well matched by patient age, weight and body surface area. The overall percentage attenuation by the cream on the operator’s hand was 39.7% and was not affected by procedure duration or increased radiation doses. The overall median percentage satisfaction was 92% among all operators with ease of application and tactile sensation generally well rated.

 

The authors conclude that the UltraBloxTM cream provides a new option for radio-protection for the hands of the pediatric interventional cardiologist, offering 40% radiation attenuation. The protection decreases neither for prolonged procedures (up to 180 minutes) nor with increasing radiation doses. Operators rated the cream as relatively easy to use with little loss of tactile sensation.

 

 

Infective Endocarditis Risk After Percutaneous Pulmonary Valve Implantation with the Melody and Sapien Valves.

Hascoet S, Mauri L, Claude C, Fournier E, Lourtet J, Riou JY, Brenot P, Petit J.

JACC Cardiovasc Interv. 2017 Mar 13;10(5):510-517. doi: 10.1016/j.jcin.2016.12.012.

 

Take Home Points:

 

  • The incidence of infective endocarditis following percutaneous pulmonary valve implantation has been of increasing concern.
  • This single center study utilizing both Melody and Sapien valves found a higher incidence of infective endocarditis in patients with Melody PPVI (5.7% per person-year) compared with Sapien PPVI (No cases during follow-up).

 

Whiteside, WendyCommentary from Dr. Wendy Whiteside (Cincinnati), section editor of Congenital Heart Disease Interventions Journal Watch: Infective endocarditis (IE) has emerged as one of the most concerning adverse outcomes following percutaneous pulmonary valve implantation (PPVI).  The annual incidence of IE after PPVI with the Melody valve is reported around 3%, however adequate quantities and duration of follow-up has not yet been available for the newer Sapien valve to allow for a balanced comparison of these valve types.

 

Hascoet et al present findings from a single center retrospective cohort study evaluating IE after PPVI between the two now commercially available transcatheter pulmonary valves—Medtronic Melody and Edwards Sapien. They looked at 79 patients who received PPVI between 2008-2016.  Melody valve was used in 40.5% and Sapien in 59.5% of patients.  With its larger diameter valves available, it is not surprising that patients who received the Sapien valve were older, larger, and had a higher proportion of native right ventricular outflow tract valve implantations (not within a previously placed surgical conduit/bioprosthesis).  IE, diagnosed based on the European Society of Cardiology modified Duke algorithm, occurred in 8 patients (10.1%) a median of 1.8 years (range 12.2 months-5.6 years) after PPVI, for an incidence of 3.9% per person-year.  Median follow-up was longer in the Melody group (4.9 years, IQR 2.2-6.5) compared with the Sapien group (1.0 years, IQR 0.2-2.6). All 8 patients with IE had received Melody PPVI (IE incidence 5.7% per person-year in the Melody group compared with 0% in the Sapien group).  Valve gradient was increased at IE diagnosis in 7 of the 8 patients—4 required elective surgical valve explantation and 2 required delayed surgical valve explantation. There was one death due to septic shock the day after fever onset.

 

While this single center study allows for comparison of PPVI within a center with similar implantation technique and follow-up practices, there are important limitations, which are recurrent among studies evaluating IE among different valve types.  These include differences in follow-up duration, change in technique over time, and anatomic substrate (small stenotic conduit vs large regurgitant native outflow) for PPVI. In fact, in this case, the majority (7 IE cases) occurred among the first 19 patients performed at this center with the remaining 1 IE case occurring among the remaining cases.  Between these two-time periods, there was a change in administration practices of antibiotics from a single intraprocedural antibiotic dose to a 48-hour course, followed within a few years by a shift in the valve type used from exclusively Melody to majority Sapien.

 

While this study suggests a higher IE risk with the Melody valve that is certainly worth noting, it again points out the need for larger, multi-center studies, with longer follow-up duration to truly understand the difference between these valve types.  Being a newer valve in the pulmonary position, we do not have the same long term-follow-up and experience with the durability of the Sapien valve as with the Melody valve so caution should be taken in shifting practice now based upon these data.

 

 

 

The Medtronic Micro Vascular Plug™ for Vascular Embolization in Children with Congenital Heart Diseases.

Sathanandam S, Justino H, Waller BR 3rd, Gowda ST, Radtke W, Qureshi AM.

J Interv Cardiol. 2017 Feb 16. doi: 10.1111/joic.12369. [Epub ahead of print]

PMID: 28211168

 

Take home points:

 

  • Occlusion of abnormal blood vessels (including aorto-pulmonary and veno-venous collaterals) in patients with congenital heart disease can be challenging due to small patient size and potentially tortuous vascular anatomy.
  • The Medtronic Micro-vascular plug allows for deployment of a large diameter, detachable device for vascular occlusion/embolization through a microcatheter.

 

Commentary from Dr. Wendy Whiteside (Cincinnati), section editor of Congenital Heart Disease Interventions Journal Watch: In pediatric interventional cardiology, we are often challenged with finding devices which have a sufficiently flexible and small delivery system to be used to close medium to large structures in small patients with complex anatomy.  Sathanandam et al describe their multi-center experience with implantation of a Medtronic Micro Vascular Plug (MVP) in patients with congenital heart disease.  The MVP is the first detachable plug deliverable through a microcatheter (6.5 mm device can be introduced through 0.027” inner diameter catheter) and has been used for vascular embolization primarily in neuroradiology procedures in adults.  The device has a highly flexible 0.018” delivery wire and device has a flexible nitinol frame covered partially by a polytetrafluoroethylene membrane.

 

In this 3-center, retrospective observational study, Sathanandam et al describe the use of the MVP for occlusion of abnormal blood vessels in 8 pediatric patients (median age 3 years, median weight 14.9 kg).  Vessels occluded included veno-venous collaterals in single ventricle patients (5), aorto-pulmonary collateral vessels (2), and coronary artery fistula (3).  The most common indication for using the MVP was failed attempted occlusion using other embolic devices (5/8 patients, 62.5%) due to catheter kinking and acute vessel/catheter turns. There was complete vessel closure in all collateral vessels with no procedural or long term complications (median 7 months, range 4-12 months).  2/3 coronary artery fistula were successfully closed with one patient having distal device embolization with residual shunt.  While this study describes a limited experience in pediatric patients, its application in pediatric congenital heart patients may allow for a safer, more controlled, and more effective vessel occlusion in tortuous vessels that are too large for micro-coil placement.

 

CHD Interventions March 2017

 

  1. Infective Endocarditis Risk After Percutaneous Pulmonary Valve Implantation With the Melody and Sapien Valves.

Hascoet S, Mauri L, Claude C, Fournier E, Lourtet J, Riou JY, Brenot P, Petit J.

JACC Cardiovasc Interv. 2017 Mar 13;10(5):510-517. doi: 10.1016/j.jcin.2016.12.012.

PMID:

 

28279319

Similar articles

 

  1. Intracoronary Cardiac Progenitor Cells in Single Ventricle Physiology: The PERSEUS (Cardiac Progenitor Cell Infusion to Treat UniventricularHeartDisease) Randomized Phase 2 Trial.

Ishigami S, Ohtsuki S, Eitoku T, Ousaka D, Kondo M, Kurita Y, Hirai K, Fukushima Y, Baba K, Goto T, Horio N, Kobayashi J, Kuroko Y, Kotani Y, Arai S, Iwasaki T, Sato S, Kasahara S, Sano S, Oh H.

Circ Res. 2017 Mar 31;120(7):1162-1173. doi: 10.1161/CIRCRESAHA.116.310253. Epub 2017 Jan 4.

PMID:

 

28052915

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Select item 28366291 84

 

  1. Clinical Progress in Cell Therapy for Single VentricleCongenital Heart Disease.

Bittle GJ, Wehman B, Karathanasis SK, Kaushal S.

Circ Res. 2017 Mar 31;120(7):1060-1062. doi: 10.1161/CIRCRESAHA.117.310702. No abstract available.

PMID:

 

28360342

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Select item 28052915 83

 

  1. Patient-specific in vitro models for hemodynamic analysis ofcongenital heart disease– Additive manufacturing approach.

Medero R, García-Rodríguez S, François CJ, Roldán-Alzate A.

J Biomech. 2017 Mar 21;54:111-116. doi: 10.1016/j.jbiomech.2017.01.048. Epub 2017 Feb 7.

PMID:

 

28242061

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Select item 28318457 111.

 

  1. Current Status and Future Potential of Transcatheter Interventions inCongenital Heart Disease.

Kenny DP, Hijazi ZM.

Circ Res. 2017 Mar 17;120(6):1015-1026. doi: 10.1161/CIRCRESAHA.116.309185.

PMID:

 

28302745

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Select item 28302744 119.

 

  1. Impact of Three-Dimensional Printing on the Study and Treatment ofCongenital Heart Disease.

Bramlet M, Olivieri L, Farooqi K, Ripley B, Coakley M.

Circ Res. 2017 Mar 17;120(6):904-907. doi: 10.1161/CIRCRESAHA.116.310546. No abstract available.

PMID:

 

28302738

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Select item 28302737 126.

 

  1. Severe Aortic Stenosis and Severe Coarctation of the Aorta: A Hybrid Approach to Treatment.

McLennan D, Caputo M, Taliotis D.

Front Surg. 2017 Mar 17;4:16. doi: 10.3389/fsurg.2017.00016. eCollection 2017.

PMID:

 

28367436

Free PMC Article

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Select item 28301892 130.

 

  1. Transcatheter closure of unroofed coronary sinus using covered stents in an adult with drainage of the coronary sinus to the right ventricle after supra-annular tricuspid valve replacement.

Mohammad Nijres B, Kenny D, Kazmouz S, Hijazi ZM.

Catheter Cardiovasc Interv. 2017 Mar 15. doi: 10.1002/ccd.26996. [Epub ahead of print]

PMID:

 

28296217

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Select item 28296032 145.

 

  1. Right ventricular remodelling after transcatheter pulmonary valve implantation.

Pagourelias ED, Daraban AM, Mada RO, Duchenne J, Mirea O, Cools B, Heying R, Boshoff D, Bogaert J, Budts W, Gewillig M, Voigt JU.

Catheter Cardiovasc Interv. 2017 Mar 15. doi: 10.1002/ccd.26966. [Epub ahead of print]

PMID:

 

28296032

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Select item 28296023 146.

 

  1. Closure of patent forman ovale defects using GORE® CARDIOFORM septal occluder.

Hardt SE, Eicken A, Berger F, Schubert S, Carminati M, Butera G, Grohmann J, Höhn R, Nielsen-Kudsk JE, Hildick-Smith D, Settergren M, Thomson JD, Geis N, Søndergaard L.

Catheter Cardiovasc Interv. 2017 Mar 15. doi: 10.1002/ccd.26993. [Epub ahead of print]

PMID:

 

28296023

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Select item 28295963 147.

 

  1. A multicenter study of the impella device for mechanical support of the systemic circulation in pediatric and adolescent patients.

Dimas VV, Morray BH, Kim DW, Almond CS, Shahanavaz S, Tume SC, Peng LF, McElhinney DB, Justino H.

Catheter Cardiovasc Interv. 2017 Mar 15. doi: 10.1002/ccd.26973. [Epub ahead of print]

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  1. Effect of Recorded Maternal Voice on Child’s Cooperation During Cardiac Catheterization – A randomized controlled trial.

Rajan D, Lakshmanan G, Gupta SK, Sivasubramanian R, Saxena A, Juneja R.

Indian Pediatr. 2017 Mar 15;54(3):204-207. Epub 2017 Feb 2.

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  1. A new method to predict the need for a Rashkind procedure in fetuses with dextro-transposition of the great arteries.

Słodki M, Axt-Fliedner R, Zych-Krekora K, Wolter A, Kawecki A, Enzensberge C, Gulczyńska E, Respondek-Liberska M; International Prenatal Cardiology Collaboration Group..

Ultrasound Obstet Gynecol. 2017 Mar 14. doi: 10.1002/uog.17469. [Epub ahead of print]

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  1. Angiographically detectable Thebesian veins are a dynamic and reversible finding in the setting ofcongenital heart disease.

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Congenit Heart Dis. 2017 Mar 10. doi: 10.1111/chd.12457. [Epub ahead of print]

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  1. Paediatric cardiac catheterisation in Norway: rates and types of complications in new terms.

Ravndal ME, Christensen AH, Døhlen G, Holmstrøm H.

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  1. Intraoperative Stenting of Pulmonary Artery Stenosis in Children WithCongenital Heart Disease.

Meot M, Lefort B, El Arid JM, Soulé N, Lothion-Boulanger J, Lengellé F, Chantepie A, Neville P.

Ann Thorac Surg. 2017 Mar 5. pii: S0003-4975(16)31825-2. doi: 10.1016/j.athoracsur.2016.12.012. [Epub ahead of print]

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Góreczny S, Dryżek P, Morgan GJ, Mazurek-Kula A, Moll JJ, Moll JA, Qureshi S, Moszura T.

Arch Med Sci. 2017 Mar 1;13(2):337-345. doi: 10.5114/aoms.2016.61836. Epub 2016 Nov 28.

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28261286

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  1. Immediate and long-term outcomes of percutaneous transcatheter pulmonary valve implantation.

Fiszer R, Dryżek P, Szkutnik M, Góreczny S, Krawczuk A, Moll J, Moszura T, Pawlak S, Białkowski J.

Cardiol J. 2017 Mar 1. doi: 10.5603/CJ.a2017.0023. [Epub ahead of print]

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28248409

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  1. Psychosocial needs of children undergoing an invasive procedure for a CHD and their parents.

Levert EM, Helbing WA, Dulfer K, van Domburg RT, Utens EM.

Cardiol Young. 2017 Mar;27(2):243-254. doi: 10.1017/S1047951116000391. Epub 2016 Apr 8.

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  1. Clinically apparent long-term electric disturbances in the acute and very long-term of patent foramen ovale device-based closure.

Rigatelli G, Zuin M, Pedon L, Zecchel R, Dell’Avvocata F, Carrozza A, Zennaro M, Pastore G, Zanon F.

Cardiovasc Revasc Med. 2017 Mar;18(2):118-122. doi: 10.1016/j.carrev.2016.10.008. Epub 2016 Oct 29.

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  1. Techniques for transcatheter retrieval of the occlutech ASD device United Kingdom-European multicenter report.

Shebani SO, Rehman R, Taliotis D, Magee A, Hayes NJ, Baspinar O, Martínez Z, Haas N, Duke C.

Catheter Cardiovasc Interv. 2017 Mar 1;89(4):690-698. doi: 10.1002/ccd.26838. Epub 2016 Nov 10.

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  1. Interventional re-opening of a PDA for reverse potts shunt circulation after ADO i implantation in a child.

Schubert S, Peters B, Berger F.

Catheter Cardiovasc Interv. 2017 Mar 1;89(4):E133-E136. doi: 10.1002/ccd.26680. Epub 2016 Aug 12.

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27516058

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  1. Perventricular device closure of perimembranous ventricular septal defect: effectiveness of symmetric and asymmetric occluders.

Ou-Yang WB, Wang SZ, Hu SS, Zhang FW, Zhang DW, Liu Y, Meng H, Pang KJ, Meng LK, Pan XB.

Eur J Cardiothorac Surg. 2017 Mar 1;51(3):478-482. doi: 10.1093/ejcts/ezw352.

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28082474

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  1. Seven Coils in 1 Heart: Therapeutic Option for Multiple VSD.

Sabiniewicz R, Weryński P.

JACC Cardiovasc Interv. 2017 Mar 24. pii: S1936-8798(17)30328-X. doi: 10.1016/j.jcin.2017.02.016. [Epub ahead of print] No abstract available.

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28365261

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  1. Treatment of severe refractory valvar pulmonary stenosis with primary transcatheter pulmonary valve implantation.

Trivedi KR, Robinson L, Fraisse A.

Cardiol Young. 2017 Mar 23:1-3. doi: 10.1017/S1047951117000191. [Epub ahead of print]

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  1. Intractable Back Pain After Coil Embolization of Giant Veno-Venous Collaterals in a Patient With Fontan Circulation.

Okada S, Kamada M, Nakagawa N, Ishiguchi Y, Moritoh Y, Shohi M, Okamoto K, Hasegawa S, Ohga S.

Int Heart J. 2017 Mar 21. doi: 10.1536/ihj.16-194. [Epub ahead of print]

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  1. Distribution of Kawasaki Disease Coronary Artery Aneurysms and the Relationship to Coronary Artery Diameter.

Tsuda E, Tsujii N, Kimura K, Suzuki A.

Pediatr Cardiol. 2017 Mar 20. doi: 10.1007/s00246-017-1599-4. [Epub ahead of print]

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  1. Giant aneurysms: A gender-specific complication of Kawasaki disease?

Dietz SM, Kuipers IM, Tacke CE, Koole JC, Hutten BA, Kuijpers TW.

J Cardiol. 2017 Mar 18. pii: S0914-5087(17)30017-5. doi: 10.1016/j.jjcc.2016.12.014. [Epub ahead of print]

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  1. Anchor balloon, buddy wire, and wire and sheath techniques to deploy percutaneous pulmonary valves in tetralogy of fallot patients.

Shah RR, Poommipanit P, Law MA, Amin Z.

Catheter Cardiovasc Interv. 2017 Mar 17. doi: 10.1002/ccd.27022. [Epub ahead of print]

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  1. Into the hearts of babes: Stem cell therapy for pediatricheart failure.

Garbern JC, Daly KP.

J Heart Lung Transplant. 2017 Mar 9. pii: S1053-2498(17)31683-2. doi: 10.1016/j.healun.2017.03.006. [Epub ahead of print] No abstract available.

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28365176

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  1. Hemolytic Anemia due to Right Ventricular to Pulmonary Artery Conduit Stenosis.

Rao S, Creaden JA, Gong S, Rigsby C, Costello JM.

J Pediatr Hematol Oncol. 2017 Mar 6. doi: 10.1097/MPH.0000000000000801. [Epub ahead of print]

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  1. Transcatheter closure of patent ductus arteriosus using the AMPLATZER™ duct occluder II (ADO II).

Gruenstein DH, Ebeid M, Radtke W, Moore P, Holzer R, Justino H.

Catheter Cardiovasc Interv. 2017 Mar 4. doi: 10.1002/ccd.26968. [Epub ahead of print]

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  1. Clinical evaluation of a radio-protective cream for the hands of the pediatricinterventional cardiologist.

Subramanian S, Waller BR, Winders N, Bird LE, Agrawal V, Zurakowski D, Kuhls-Gilcrist A, Khandkar A, Sathanandam SK.

Catheter Cardiovasc Interv. 2017 Mar 1;89(4):709-716. doi: 10.1002/ccd.26845. Epub 2016 Nov 26.

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  1. Stenting of the ductus arteriosus in infants with functionally univentricular heart disease and ductal-dependent pulmonary blood flow: A single-center experience.

Celebi A, Yucel IK, Bulut MO, Kucuk M, Balli S.

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  1. Closure of very large PDA with pulmonary hypertension: Initial clinical case-series with the new Occlutech®PDA occluder.

Lehner A, Ulrich S, Happel CM, Fischer M, Kantzis M, Schulze-Neick I, Haas NA.

Catheter Cardiovasc Interv. 2017 Mar 1;89(4):718-725. doi: 10.1002/ccd.26856. Epub 2016 Nov 10.

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  1. Sheath placement in femoral artery during cardiac catheterization in children can influence pressure waveform.

Shiraishi M, Murakami T, Nawa T, Higashi K, Nakajima H, Aotsuka H.

Int J Cardiol. 2017 Mar 1;230:21-24. doi: 10.1016/j.ijcard.2016.12.118. Epub 2016 Dec 22.

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  1. An in vivo pilot study of a microporous thin film nitinol-covered stent to assess the effect of porosity and pore geometry on device interaction with the vessel wall.

Chun Y, Kealey CP, Levi DS, Rigberg DA, Chen Y, Tillman BW, Mohanchandra KP, Shayan M, Carman GP.

J Biomater Appl. 2017 Mar;31(8):1196-1202. doi: 10.1177/0885328216682691. Epub 2016 Dec 8.

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  1. Perimembranous Ventricular Septal Defect Device Closure: Choosing Between Amplatzer Duct Occluder I and II.

El-Sisi A, Sobhy R, Jaccoub V, Hamza H.

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  1. Myocardial Infarction in Neonates: A Review of an Entity with Significant Morbidity and Mortality.

Papneja K, Chan AK, Mondal TK, Paes B.

Pediatr Cardiol. 2017 Mar;38(3):427-441. doi: 10.1007/s00246-016-1556-7. Epub 2017 Feb 25. Review.

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  1. Comparison of Patients Undergoing Surgical Versus Transcatheter Pulmonary Valve Replacement: Criteria for Referral and Mid-Term Outcome.

Zablah JE, Misra N, Gruber D, Kholwadwala D, Epstein S.

Pediatr Cardiol. 2017 Mar;38(3):603-607. doi: 10.1007/s00246-016-1554-9. Epub 2017 Feb 25.

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  1. Anomalous Coronary Arteries and Myocardial Bridges: Risk Stratification in Children Using Novel Cardiac Catheterization Techniques.

Agrawal H, Molossi S, Alam M, Sexson-Tejtel SK, Mery CM, McKenzie ED, Fraser CD Jr, Qureshi AM.

Pediatr Cardiol. 2017 Mar;38(3):624-630. doi: 10.1007/s00246-016-1559-4. Epub 2017 Feb 18.

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  1. Initial Experience with Elective Perventricular Melody Valve Placement in Small Patients.

Gupta A, Kenny D, Caputo M, Amin Z.

Pediatr Cardiol. 2017 Mar;38(3):575-581. doi: 10.1007/s00246-016-1550-0. Epub 2016 Dec 20.

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  1. Transcatheter Pulmonary Valve Replacement and Acute Increase in Diastolic Pressure are Associated with Increases in Both Systolic and Diastolic Pulmonary Artery Dimensions.

Callahan R, Bergersen L, Lock JE, Marshall AC.

Pediatr Cardiol. 2017 Mar;38(3):456-464. doi: 10.1007/s00246-016-1535-z. Epub 2016 Nov 23.

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  1. Echocardiographic right ventricular function correlations with cardiac catheterisation data in biventricular congenital heart patients.

Nadorlik H, Stiver C, Khan S, Miao Y, Holzer R, Cheatham JP, Cua CL.

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  1. Usefulness of intracardiac echocardiography for the diagnosis of infective endocarditis following percutaneous pulmonary valve replacement.

Bouajila S, Chalard A, Dauphin C.

Cardiol Young. 2017 Mar 21:1-4. doi: 10.1017/S1047951117000403. [Epub ahead of print]

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  1. Paediatric cardiac catheterisation in Norway: rates and types of complications in new terms.

Ravndal ME, Christensen AH, Døhlen G, Holmstrøm H.

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  1. Stent implantation to ductus arteriosus in a patient with interrupted aortic arch guided by CT image overlay.

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Cardiol Young. 2017 Mar 6:1-3. doi: 10.1017/S1047951117000154. [Epub ahead of print]

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  1. Aortic rupture during stenting for recurrent aortic coarctation in an adult: live-saving, emergency, NuDEL all-in-one covered stent implantation.

Eicken A, Georgiev S, Ewert P.

Cardiol Young. 2017 Mar 6:1-4. doi: 10.1017/S1047951117000142. [Epub ahead of print]

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28260540

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  1. Infective endocarditis following Melody valve implantation: comparison with a surgical cohort.

O’Donnell C, Holloway R, Tilton E, Stirling J, Finucane K, Wilson N.

Cardiol Young. 2017 Mar;27(2):294-301. doi: 10.1017/S1047951116000494. Epub 2016 May 10.

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Fetal Cardiology Featured Articles of February 2017

Fetal Cardiology Feb 2017

Teratogenicity of Antiepileptic Drugs.

Güveli BT, Rosti RÖ, Güzeltaş A, Tuna EB, Ataklı D, Sencer S, Yekeler E, Kayserili H, Dirican A, Bebek N, Baykan B, Gökyiğit A, Gürses C.

Clin Psychopharmacol Neurosci. 2017 Feb 28;15(1):19-27. doi: 10.9758/cpn.2017.15.1.19.

PMID: 28138106 Free PMC Article

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  1. A Comprehensive TALEN-Based Knockout Library for Generating Human Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases.

Karakikes I, Termglinchan V, Cepeda DA, Lee J, Diecke S, Hendel A, Itzhaki I, Ameen M, Shrestha R, Wu H, Ma N, Shao NY, Seeger T, Woo NA, Wilson KD, Matsa E, Porteus MH, Sebastiano V, Wu JC.

Circ Res. 2017 Feb 28. pii: CIRCRESAHA.116.309948. doi: 10.1161/CIRCRESAHA.116.309948. [Epub ahead of print]

PMID: 28246128

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  1. Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation.

Zhou L, Liu J, Xiang M, Olson P, Guzzetta A, Zhang K, Moskowitz IP, Xie L.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1422-E1431. doi: 10.1073/pnas.1605137114.

PMID: 28167794

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  1. Increased regurgitant flow causes endocardial cushion defects in an avian embryonic model of congenital heart disease.

Ford SM, McPheeters MT, Wang YT, Ma P, Gu S, Strainic J, Snyder C, Rollins AM, Watanabe M, Jenkins MW.

Congenit Heart Dis. 2017 Feb 17. doi: 10.1111/chd.12443. [Epub ahead of print]

PMID: 28211263

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  1. Increased Hemodynamic Load in Early Embryonic Stages Alters Endocardial to Mesenchymal Transition.

Midgett M, López CS, David L, Maloyan A, Rugonyi S.

Front Physiol. 2017 Feb 8;8:56. doi: 10.3389/fphys.2017.00056.

PMID: 28228731 Free PMC Article

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  1. Total anomalous pulmonary venous connection to an unroofed coronary sinus diagnosed in a fetus with associated spinal muscular atrophy type I.

Krupickova S, Rigby ML, Jicinska H, Marais G, Rubens M, Carvalho JS.

Ultrasound Obstet Gynecol. 2017 Feb 7. doi: 10.1002/uog.17432. [Epub ahead of print]

PMID: 28170121

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  1. Mutation Screening of Gata4 Gene in CTD Patients Within Chinese Han Population.

Liu Y, Li B, Xu Y, Sun K.

Pediatr Cardiol. 2017 Feb 4. doi: 10.1007/s00246-016-1542-0. [Epub ahead of print]

PMID: 28161810

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  1. Mechanisms of Cardiomyocyte Proliferation and Differentiation in Development and Regeneration.

Yester JW, Kühn B.

Curr Cardiol Rep. 2017 Feb;19(2):13. doi: 10.1007/s11886-017-0826-1. Review.

PMID: 28185170

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  1. Prenatal diagnosis of idiopathic infantile arterial calcification without fetal hydrops.

Yi Y, Tong T, Liu T, Lin Q, Xiong Y, Xu J.

Echocardiography. 2017 Feb;34(2):311-314. doi: 10.1111/echo.13420.

PMID: 27928837

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  1. Automated annotation and quantitative description of ultrasound videos of the fetal heart.

Bridge CP, Ioannou C, Noble JA.

Med Image Anal. 2017 Feb;36:147-161. doi: 10.1016/j.media.2016.11.006.

PMID: 27907850 Free Article

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  1. Prenatal diagnoses of an uncommon isolated obstructed supracardiac total anomalous pulmonary venous connection: Case report and review of the literature (CARE compliant).

Muntean I, Mărginean C, Stanca R, Togănel R, Pop M, Gozar L.

Medicine (Baltimore). 2017 Feb;96(5):e6061. doi: 10.1097/MD.0000000000006061. Review.

PMID: 28151919 Free PMC Article

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  1. Reference Ranges of Fetal Cardiac Biometric Parameters Using Three-Dimensional Ultrasound with Spatiotemporal Image Correlation M Mode and Their Applicability in Congenital Heart Diseases.

Tedesco GD, de Souza Bezerra M, Barros FS, Martins WP, Nardozza LM, Carrilho MC, Moron AF, Carvalho FH, Rolo LC, Araujo Júnior E.

Pediatr Cardiol. 2017 Feb;38(2):271-279. doi: 10.1007/s00246-016-1509-1.

PMID: 27878625

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  1. Basic heart examination: feasibility study of first-trimester systematic simplified fetal echocardiography.

Quarello E, Lafouge A, Fries N, Salomon LJ; CFEF..

Ultrasound Obstet Gynecol. 2017 Feb;49(2):224-230. doi: 10.1002/uog.15866.

PMID: 26799640

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  1. Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis.

Familiari A, Morlando M, Khalil A, Sonesson SE, Scala C, Rizzo G, Del Sordo G, Vassallo C, Elena Flacco M, Manzoli L, Lanzone A, Scambia G, Acharya G, D’Antonio F.

Circulation. 2017 Feb 21;135(8):772-785. doi: 10.1161/CIRCULATIONAHA.116.024068.

PMID: 28034902

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  1. Vegfa Impacts Early Myocardium Development in Zebrafish.

Zhu D, Fang Y, Gao K, Shen J, Zhong TP, Li F.

Int J Mol Sci. 2017 Feb 21;18(2). pii: E444. doi: 10.3390/ijms18020444.

PMID: 28230770 Free Article

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  1. Increased regurgitant flow causes endocardial cushion defects in an avian embryonic model of congenital heart disease.

Ford SM, McPheeters MT, Wang YT, Ma P, Gu S, Strainic J, Snyder C, Rollins AM, Watanabe M, Jenkins MW.

Congenit Heart Dis. 2017 Feb 17. doi: 10.1111/chd.12443. [Epub ahead of print]

PMID: 28211263

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  1. Toward Improving the Fetal Diagnosis of Coarctation of the Aorta.

Beattie M, Peyvandi S, Ganesan S, Moon-Grady A.

Pediatr Cardiol. 2017 Feb;38(2):344-352. doi: 10.1007/s00246-016-1520-6.

PMID: 27888318

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  1. Reference Ranges of Fetal Cardiac Biometric Parameters Using Three-Dimensional Ultrasound with Spatiotemporal Image Correlation M Mode and Their Applicability in Congenital Heart Diseases.

Tedesco GD, de Souza Bezerra M, Barros FS, Martins WP, Nardozza LM, Carrilho MC, Moron AF, Carvalho FH, Rolo LC, Araujo Júnior E.

Pediatr Cardiol. 2017 Feb;38(2):271-279. doi: 10.1007/s00246-016-1509-1.

PMID: 27878625

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  1. Area of the fetal heart’s four-chamber view: a practical screening tool to improve detection of cardiac abnormalities in a low-risk population.

DeVore GR, Satou G, Sklansky M.

Prenat Diagn. 2017 Feb;37(2):151-155. doi: 10.1002/pd.4980.

PMID: 27943393

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  1. Fetal magnetocardiography using optically pumped magnetometers: a more adaptable and less expensive alternative?

Eswaran H, Escalona-Vargas D, Bolin EH, Wilson JD, Lowery CL.

Prenat Diagn. 2017 Feb;37(2):193-196. doi: 10.1002/pd.4976.

PMID: 27891637

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  1. Diverse outcome following early prenatal diagnosis of pulmonary stenosis.

Bronshtein M, Blumenfeld Z, Khoury A, Gover A.

Ultrasound Obstet Gynecol. 2017 Feb;49(2):213-218. doi: 10.1002/uog.17332.

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Chidambarathanu S, Raja V, Suresh I.

Ann Pediatr Cardiol. 2017 Jan-Apr;10(1):72-74. doi: 10.4103/0974-2069.197062.

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