Fetal Cardiology Featured Articles of November 2016

Cardiac output and blood flow redistribution in the fetus with D-loop transposition of the great arteries and intact ventricular septum: insights into the pathophysiology.

Godfrey ME, Friedman KG, Drogosz M, Rudolph AM, Tworetzky W.

Ultrasound Obstet Gynecol. 2016 Nov 22. doi: 10.1002/uog.17370. [Epub ahead of print]

Take Home Points:

  1. In normal fetal circulation the right ventricle contributes about 60% to combined cardiac output. In d-transposition of the great arteries (d-TGA) with intact ventricular septum the right and left ventricular components of combined ventricular output are about equal.
  2. 75% of fetuses with d-TGA with intact ventricular septum had bidirectional flow across the foramen ovale and about a third had bidirectional flow at the ductus arteriosus.
  3. These findings support previous postulations from Dr. Rudolph concerning the pathophysiology of fetal blood flow in d-TGA. Specifically, that increased pulmonary arterial p02 leads to pulmonary vasodilation that in turn increases pulmonary artery blood flow with subsequent increases in pulmonary venous return to the left atrium raising the left atrial pressure contributing to bidirectional flow across the foramen ovale.

Abarbanell picture smallCommentary from Dr. Ginnie Abarbanell (Atlanta), section editor of Fetal Cardiology Journal Watch: This fetal study evaluated the changes in blood flow physiology in d-transposition of the great arteries (d-TGA) with intact ventricular septum compared to normal fetal cardiac blood flow.  Data was collected on 74 consecutive fetuses with d-TGA with intact ventricular septum.  Compared to the controls the left ventricular component of combined ventricular output was higher at 50.7% compared to 40.2% with no difference in total combined ventricular output.  75.7% of fetuses had bidirectional flow at the foramen ovale and slightly over a third (32.4%) had bidirectional flow at the ductus arteriosus.  Bidirectional shunting was more common in the 3rd trimester.  The pulmonary valve is larger compared to the aortic valve in normal fetuses.  In this study, the pulmonary and aortic valves were nearly identical in size.  There was no difference in the middle cerebral artery Doppler indices or pulsatility index found in fetuses with d-TGA vs. normal fetuses.  In the discussion, the authors relate these findings to those postulated by Dr. Rudolph 1 who proposed that increased pulmonary arterial p02 as in d-TGA leads to pulmonary vasodilation and constriction of the ductus arteriosus in turn increasing the pulmonary artery blood flow.  The increased pulmonary artery blood flow combined with decreased right to left ductal flow leads to increased pulmonary venous return to the left atrium, which raises the left atrial pressure and contributes to the bidirectional flow across the foramen ovale.  The results from this study are in congruence with Dr. Rudolph’s proposal in that there was increased left ventricular output (i.e. increased pulmonary blood flow) with increased bidirectional shunting at the ductus arteriosus secondary to probable decreased pulmonary resistance and increased bidirectional shunting at the foramen ovale most likely secondary to decreased pulmonary resistance with increased pulmonary venous return to the left atrium.

1. Rudolph AM. Aortopulmonary transposition in the fetus: speculation on pathophysiology and therapy. Pediatr Res. 2007 Mar;61(3):375–80.

fetal 1

 

Toward Improving the Fetal Diagnosis of Coarctation of the Aorta.

Beattie M, Peyvandi S, Ganesan S, Moon-Grady A.

Pediatr Cardiol. 2016 Nov 25. [Epub ahead of print]

Take Home Points:

  1. This study sought to determine the best markers on fetal echocardiogram that predict neonatal coarctation of the aorta.
  2. 2D parameters of ascending aorta z-score, aortic isthmus z-score and the aortic isthmus/ductus arteriosus ratio on fetal echo were the most predictive of postnatal coarctation of the aorta.
  3. This study found increased sensitivity for detecting coarctation on fetal echocardiogram when a combination of an aorta/pulmonary ratio ≤ 0.65 and diastolic persistence of flow at the aortic isthmus were present but at the expense of an increased false positive rate.
  4. The authors propose a stepwise evaluation for fetal coarctation with first evaluating the 2D findings (i.e. ascending aorta z-score, aortic isthmus z-score and the aortic isthmus/ductus arteriosus ratio) and if 2D findings are equivocal, then a combination of an aorta/pulmonary artery ratio ≤ 0.65 and diastolic persistence of flow may be useful to further predict the presence of fetal coarctation of the aorta.

Comment from Dr. Ginnie Abarbanell (Atlanta), section editor of Fetal Cardiology Journal Watch: Coarctation of the aorta can be difficult to diagnose in utero and unfortunately has a low detection rate on neonatal pulse oximetry screening.  Hence, several studies have been published trying to identify the most helpful findings on fetal echocardiogram to make a prenatal diagnosis of coarctation.  This retrospective study from the University of California San Francisco reviewed fetal echocardiograms of 62 fetuses with a diagnosis of probable coarctation of the aorta.  72.5% postnatally were confirmed as having a coarctation of the aorta.  The following 2D parameters were the most predictive of postnatal coarctation of the aorta:  ascending aorta z-score, aortic isthmus z-score and the aortic isthmus/ductus arteriosus ratio.  The left ventricle/right ventricular size ratio, presence of an aortic isthmus shelf or the mitral valve/tricuspid valve ratio were not significantly predictors of coarctation.  There was improved sensitivity for presence of postnatal coarctation when there was an aorta/pulmonary artery ratio ≤ 0.65 and diastolic persistence of flow at the aortic isthmus. See Figure.   However, with improved sensitivity there was an increased false positive rate.  The authors propose a “stepwise” approach when diagnosing fetal coarctation.  This approach would initially focus on 2D evaluation of the fetal arch with specific attention to the ascending aorta size (z-score), aortic isthmus size (z-score) and the aortic isthmus/ductus arteriosus ratio.  When these parameters are equivocal, a combination of the aorta/pulmonary artery ratio ≤ 0.65 with diastolic persistence of flow maybe useful to further predict the presence of fetal coarctation of the aorta.

 

fetal 2

 


Fetal Cardiology and Genetics Articles – November 2016

  1. Cardiovascular profile score as a predictor of acute intrapartum non-reassuring fetal status in infants with congenital heart defects.

Miyoshi T, Katsuragi S, Neki R, Kurosaki KI, Shiraishi I, Nakai M, Nishimura K, Yoshimatsu J, Ikeda T.

J Matern Fetal Neonatal Med. 2016 Nov 28:1-23. [Epub ahead of print]

  1. ISUOG consensus statement on current understanding of the association of neurodevelopmental delay and congenital heart disease: impact on prenatal counseling.

Paladini D, Alfirevic Z, Carvalho JS, Khalil A, Malinger G, Martinez JM, Rychik J, Ville Y, Gardiner H; ISUOG Clinical Standards Committee.

Ultrasound Obstet Gynecol. 2016 Nov 27. doi: 10.1002/uog.17324. [Epub ahead of print] No abstract available.

  1. Alcohol Exposure Causes Overexpression of Heart Development-Related Genes by Affecting the Histone H3 Acetylation via BMP Signaling Pathway in Cardiomyoblast Cells.

Shi J, Zhao W, Pan B, Zheng M, Si L, Zhu J, Liu L, Tian J.

Alcohol Clin Exp Res. 2016 Nov 24. doi: 10.1111/acer.13273. [Epub ahead of print]

  1. Reference Ranges of Fetal Cardiac Biometric Parameters Using Three-Dimensional Ultrasound with Spatiotemporal Image Correlation M Mode and Their Applicability in Congenital Heart Diseases.

Tedesco GD, de Souza Bezerra M, Barros FS, Martins WP, Nardozza LM, Carrilho MC, Moron AF, Carvalho FH, Rolo LC, Araujo Júnior E.

Pediatr Cardiol. 2016 Nov 23. [Epub ahead of print]

  1. Cardiac output and blood flow redistribution in the fetus with D-loop transposition of the great arteries and intact ventricular septum: insights into the pathophysiology.

Godfrey ME, Friedman KG, Drogosz M, Rudolph AM, Tworetzky W.

Ultrasound Obstet Gynecol. 2016 Nov 22. doi: 10.1002/uog.17370. [Epub ahead of print]

  1. Transcriptomic Profiling Maps Anatomically Patterned Subpopulations among Single Embryonic Cardiac Cells.

Li G, Xu A, Sim S, Priest JR, Tian X, Khan T, Quertermous T, Zhou B, Tsao PS, Quake SR, Wu SM.

Dev Cell. 2016 Nov 21;39(4):491-507. doi: 10.1016/j.devcel.2016.10.014.

  1. Single-Cell Resolution of Temporal Gene Expression during Heart Development.

DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau BG, Seidman JG, Seidman CE.

Dev Cell. 2016 Nov 21;39(4):480-490. doi: 10.1016/j.devcel.2016.10.001.

  1. Genetic determinants of myocardial dysfunction.

Li X, Zhang P.

J Med Genet. 2016 Nov 21. pii: jmedgenet-2016-104308. doi: 10.1136/jmedgenet-2016-104308. [Epub ahead of print] Review.

  1. Automated annotation and quantitative description of ultrasound videos of the fetal heart.

Bridge CP, Ioannou C, Noble JA.

Med Image Anal. 2016 Nov 19;36:147-161. doi: 10.1016/j.media.2016.11.006. [Epub ahead of print]

  1. Successful Fetal Tele-Echo at a Small Regional Hospital.

Brown J, Holland B.

Telemed J E Health. 2016 Nov 18. [Epub ahead of print]

  1. Molecular genetics testing for familial absence of the left ventricular outflow tract: A rare malformation.

Sun F, Chen Y, Xu S, Xiao Y, Ren W, Zhang Y.

Int J Cardiol. 2016 Nov 15;223:7-9. doi: 10.1016/j.ijcard.2016.08.153. No abstract available.

  1. Transgenerational cardiology: One way to a baby’s heart is through the mother.

Jay PY, Akhirome E, Magnan RA, Zhang MR, Kang L, Qin Y, Ugwu N, Regmi SD, Nogee JM, Cheverud JM.

Mol Cell Endocrinol. 2016 Nov 5;435:94-102. doi: 10.1016/j.mce.2016.08.029.

  1. Identification of candidate genes for congenital heart defects on proximal chromosome 8p.

Li T, Liu C, Xu Y, Guo Q, Chen S, Sun K, Xu R.

Sci Rep. 2016 Nov 3;6:36133. doi: 10.1038/srep36133.

  1. In vivo functional consequences of human THRA variants expressed in the zebrafish.

Marelli F, Carra S, Rurale G, Cotelli F, Persani L.

Thyroid. 2016 Nov 3. [Epub ahead of print]

  1. Genetics of Congenital Heart Disease: Past and Present.

Muntean I, Togănel R, Benedek T.

Biochem Genet. 2016 Nov 2. [Epub ahead of print] Review.

  1. 14-3-3epsilon controls multiple developmental processes in the mouse heart.

Gittenberger-de Groot AC, Hoppenbrouwers T, Miquerol L, Kosaka Y, Poelmann RE, Wisse LJ, Yost HJ, Jongbloed MR, Deruiter MC, Brunelli L.

Dev Dyn. 2016 Nov;245(11):1107-1123. doi: 10.1002/dvdy.24440.

  1. Disruption of cardiogenesis in human embryonic stem cells exposed to trichloroethylene.

Jiang Y, Wang D, Zhang G, Wang G, Tong J, Chen T.

Environ Toxicol. 2016 Nov;31(11):1372-1380. doi: 10.1002/tox.22142.

  1. Interchromosomal core duplicons drive both evolutionary instability and disease susceptibility of the Chromosome 8p23.1 region.

Mohajeri K, Cantsilieris S, Huddleston J, Nelson BJ, Coe BP, Campbell CD, Baker C, Harshman L, Munson KM, Kronenberg ZN, Kremitzki M, Raja A, Catacchio CR, Graves TA, Wilson RK, Ventura M, Eichler EE.

Genome Res. 2016 Nov;26(11):1453-1467.

  1. Zebrafish models of cardiovascular disease.

Bournele D, Beis D.

Heart Fail Rev. 2016 Nov;21(6):803-813.

  1. Pre- and Postnatal Diagnosis of 5q35.1 and 8p23.1 Deletion in Congenital Heart Disease.

Shetty M, Srikanth A, Kulshreshtha P, Kadandale J, Hegde S.

Indian J Pediatr. 2016 Nov;83(12-13):1484-1485. No abstract available.

  1. A systematic review of prenatal screening for congenital heart disease by fetal electrocardiography.

Verdurmen KM, Eijsvoogel NB, Lempersz C, Vullings R, Schroer C, van Laar JO, Oei SG.

Int J Gynaecol Obstet. 2016 Nov;135(2):129-134. doi: 10.1016/j.ijgo.2016.05.010. Review.

  1. Surgical repair of left ventricular pseudoaneurysm following perventricular device closure of muscular ventricular septal defect.

Taqatqa AS, Caputo M, Kenny DP, Diab KA.

J Card Surg. 2016 Nov;31(11):697-699. doi: 10.1111/jocs.12840.

  1. Reduced fetal brain fissures depth in fetuses with congenital heart diseases.

Peng Q, Zhou Q, Zang M, Zhou J, Xu R, Wang T, Zeng S.

Prenat Diagn. 2016 Nov;36(11):1047-1053. doi: 10.1002/pd.4931.

  1. Emerging Field of Cardiomics: High-Throughput Investigations into Transcriptional Regulation of Cardiovascular Development and Disease.

Slagle CE, Conlon FL.

Trends Genet. 2016 Nov;32(11):707-716. doi: 10.1016/j.tig.2016.09.002. Review.

  1. Fetal Magnetocardiography using Optically Pumped Magnetometers: A More Adaptable and Less Expensive Alternative?

Eswaran H, Escalona-Vargas D, Bolin EH, Wilson JD, Lowery CL.

Prenat Diagn. 2016 Nov 27. doi: 10.1002/pd.4976. [Epub ahead of print] No abstract available.

  1. Toward Improving the Fetal Diagnosis of Coarctation of the Aorta.

Beattie M, Peyvandi S, Ganesan S, Moon-Grady A.

Pediatr Cardiol. 2016 Nov 25. [Epub ahead of print]

  1. Reference Ranges of Fetal Cardiac Biometric Parameters Using Three-Dimensional Ultrasound with Spatiotemporal Image Correlation M Mode and Their Applicability in Congenital Heart Diseases.

Tedesco GD, de Souza Bezerra M, Barros FS, Martins WP, Nardozza LM, Carrilho MC, Moron AF, Carvalho FH, Rolo LC, Araujo Júnior E.

Pediatr Cardiol. 2016 Nov 23. [Epub ahead of print]

  1. Thorax-to-head ratio and defect diameter-to-head ratio in giant omphaloceles as predictor for fetal outcome.

Diemon N, Funke K, Möllers M, Hammer K, Steinhard J, Sauerland C, Müller V, Klockenbusch W, Schmitz R.

Arch Gynecol Obstet. 2016 Nov 11. [Epub ahead of print]

  1. Prediction of neonatal outcome of TTTS by fetal heart and Doppler ultrasound parameters before and after laser treatment.

Delabaere A, Leduc F, Reboul Q, Fuchs F, Wavrant S, Fouron JC, Audibert F.

Prenat Diagn. 2016 Nov 3. doi: 10.1002/pd.4956. [Epub ahead of print]

  1. Pregnancy complications in singleton pregnancies with isolated fetal heart defects.

van Velzen CL, Türkeri F, Pajkrt E, Clur SA, Rijlaarsdam ME, Bax CJ, Hruda J, de Groot CJ, Blom NA, Haak MC.

Acta Obstet Gynecol Scand. 2016 Nov;95(11):1273-1280. doi: 10.1111/aogs.12955.

  1. Predicting outcome in 259 fetuses with agenesis of ductus venosus – a multicenter experience and systematic review of the literature (.).

Moaddab A, Tonni G, Grisolia G, Bonasoni MP, Araujo Júnior E, Rolo LC, Prefumo F, de la Fuente S, Sepulveda W, Ayres N, Ruano R.

J Matern Fetal Neonatal Med. 2016 Nov;29(22):3606-14. doi: 10.3109/14767058.2016.1144743.

  1. Prenatal Sonographic Predictors of Neonatal Coarctation of the Aorta.

Anuwutnavin S, Satou G, Chang RK, DeVore GR, Abuel A, Sklansky M.

J Ultrasound Med. 2016 Nov;35(11):2353-2364.

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CHD Intervention Featured Articles of November 2016

CHD Intervention Articles – November 2016

  1. Multicenter midterm follow-up results using the gore septal occluder for atrial septal defect closure in pediatric patients.

Grohmann J, Wildberg C, Zartner P, Abu-Tair T, Tarusinov G, Kitzmüller E, Schmoor C, Stiller B, Kampmann C.

Catheter Cardiovasc Interv. 2016 Nov 30. doi: 10.1002/ccd.26881. [Epub ahead of print]

  1. Pulmonary artery dissection following balloon valvuloplasty in a dog with pulmonic stenosis.

Grint KA, Kellihan HB.

J Vet Cardiol. 2016 Nov 30. pii: S1760-2734(16)30104-7. doi: 10.1016/j.jvc.2016.09.005. [Epub ahead of print]

  1. Transcatheter closure of calcified patent ductus arteriosus in older adult patients: Immediate and 12-month follow-up results.

Gu X, Zhang Q, Sun H, Fei J, Zhang X, Kutryk MJ.

Congenit Heart Dis. 2016 Nov 22. doi: 10.1111/chd.12437. [Epub ahead of print]

  1. Cardiac Catheterization in Pediatric Patients Supported by Extracorporeal Membrane Oxygenation: A 15-Year Experience.

Boscamp NS, Turner ME, Crystal M, Anderson B, Vincent JA, Torres AJ.

Pediatr Cardiol. 2016 Nov 21. [Epub ahead of print]

  1. Percutaneous Pulmonary Valve Implantation in the Native Right Ventricular Outflow Tract Using a 29-mm Edwards SAPIEN 3 Valve.

Suntharos P, Prieto LR.

World J Pediatr Congenit Heart Surg. 2016 Nov 18. pii: 2150135116655125. [Epub ahead of print]

  1. SCAI/CCAS/SPA expert consensus statement for anesthesia and sedation practice: Recommendations for patients undergoing diagnostic and therapeutic procedures in the pediatric and congenital cardiac catheterization laboratory.

Odegard KC, Vincent R, Baijal R, Daves S, Gray R, Javois A, Love B, Moore P, Nykanen D, Riegger L, Walker SG, Wilson EC.

Catheter Cardiovasc Interv. 2016 Nov 15;88(6):912-922. doi: 10.1002/ccd.26692.

  1. Bench and initial preclinical results of a novel 8 mm diameter double opposed helical biodegradable stent.

Herbert CE, Veeram Reddy S, Welch TR, Wang J, Richardson JA, Forbess JM, Nugent AW.

Catheter Cardiovasc Interv. 2016 Nov 15;88(6):902-911. doi: 10.1002/ccd.26647.

  1. Thyroidal response following iodine excess for cardiac catheterisation and intervention in early infancy.

Dechant MJ, van der Werf-Grohmann N, Neumann E, Spiekerkoetter U, Stiller B, Grohmann J.

Int J Cardiol. 2016 Nov 15;223:1014-1018. doi: 10.1016/j.ijcard.2016.08.292.

  1. Long-term follow-up of interventional closure of atrial septal defect using the Solysafe™ Septal Occluder.

Knirsch W, Quandt D, Christmann M, Hübler M, Kretschmar O.

Int J Cardiol. 2016 Nov 15;223:645-646. doi: 10.1016/j.ijcard.2016.08.074. No abstract available.

  1. Transcatheter closure of large atrial septal defects using 40 mm amplatzer septal occluder: Single group experience with short and intermediate term follow-up.

Dalvi B, Sheth K, Jain S, Pinto R.

Catheter Cardiovasc Interv. 2016 Nov 12. doi: 10.1002/ccd.26858. [Epub ahead of print]

  1. Hemodynamics of patient-specific aorta-pulmonary shunt configurations.

Piskin S, Altin HF, Yildiz O, Bakir I, Pekkan K.

J Biomech. 2016 Nov 11. pii: S0021-9290(16)31172-1. doi: 10.1016/j.jbiomech.2016.11.014. [Epub ahead of print]

  1. Large single centre experience with the Cera™ and CeraFlex™ occluders for closure of interatrial communications: usefulness of the flexible rotation feature.

Apostolopoulou SC, Tsoutsinos A, Laskari C, Kiaffas M, Rammos S.

Cardiovasc Interv Ther. 2016 Nov 10. [Epub ahead of print]

  1. Single-center experience in percutaneous closure of arterial duct with Amplatzer duct Occluder II additional sizes.

Mahmoud HT, Santoro G, Gaio G, D’Aiello FA, Capogrosso C, Palladino MT, Russo MG.

Catheter Cardiovasc Interv. 2016 Nov 10. doi: 10.1002/ccd.26860. [Epub ahead of print]

  1. Techniques for transcatheter retrieval of the occlutech ASD device United Kingdom-European multicenter report.

Shebani SO, Rehman R, Taliotis D, Magee A, Hayes NJ, Baspinar O, Martínez Z, Haas N, Duke C.

Catheter Cardiovasc Interv. 2016 Nov 10. doi: 10.1002/ccd.26838. [Epub ahead of print]

  1. Novel use of the medtronic micro vascular plug for PDA closure in preterm infants.

Wang-Giuffre EW, Breinholt JP.

Catheter Cardiovasc Interv. 2016 Nov 10. doi: 10.1002/ccd.26855. [Epub ahead of print]

  1. Total Anomalous Pulmonary Venous Connection: Preoperative Anatomy, Physiology, Imaging, and Interventional Management of Postoperative Pulmonary Venous Obstruction.

Files MD, Morray B.

Semin Cardiothorac Vasc Anesth. 2016 Nov 9. pii: 1089253216672442. [Epub ahead of print] Review.

  1. Percutaneous management of failed bioprosthetic pulmonary valves in patients with congenital heart defects.

Tarzia P, Conforti E, Giamberti A, Varrica A, Giugno L, Micheletti A, Negura D, Piazza L, Saracino A, Carminati M, Chessa M.

J Cardiovasc Med (Hagerstown). 2016 Nov 8. [Epub ahead of print]

  1. Effect of solute temperature in the measurement of cardiac output in children using the thermodilution technique.

Sathanandam S, Kashyap P, Zurakowski D, Bird L, McGhee V, Towbin J, Rush Waller B 3rd.

Congenit Heart Dis. 2016 Nov 4. doi: 10.1111/chd.12423. [Epub ahead of print]

  1. SCAI/CCAS/SPA Expert Consensus Statement for Anesthesia and Sedation Practice: Recommendations for Patients Undergoing Diagnostic and Therapeutic Procedures in the Pediatric and Congenital Cardiac Catheterization Laboratory.

Odegard KC, Vincent R, Baijal RG, Daves SM, Gray RG, Javois AJ, Love BA, Moore P, Nykanen D, Riegger LQ, Walker SG, Wilson EC.

Anesth Analg. 2016 Nov;123(5):1201-1209.

  1. Hybrid pulmonary artery plication followed by transcatheter pulmonary valve replacement: Comparison with surgical PVR.

Sosnowski C, Matella T, Fogg L, Ilbawi M, Nagaraj H, Kavinsky C, Wolf AR, Diab K, Caputo M, Kenny D.

Catheter Cardiovasc Interv. 2016 Nov;88(5):804-810. doi: 10.1002/ccd.26620.

  1. Aortic root compression during transcatheter pulmonary valve replacement.

Lindsay I, Aboulhosn J, Salem M, Levi D.

Catheter Cardiovasc Interv. 2016 Nov;88(5):814-821. doi: 10.1002/ccd.26547.

  1. Optical coherence tomography for hypertensive pulmonary vasculature.

Jiang X, Peng FH, Liu QQ, Zhao QH, He J, Jiang R, Wang L, Xu XQ, Li JH, Ebrahimi R, Jing ZC.

Int J Cardiol. 2016 Nov 1;222:494-8. doi: 10.1016/j.ijcard.2016.07.215.

  1. Coronary artery anomalies in Turner Syndrome.

Viuff MH, Trolle C, Wen J, Jensen JM, Nørgaard BL, Gutmark EJ, Gutmark-Little I, Mortensen KH, Gravholt CH, Andersen NH.

J Cardiovasc Comput Tomogr. 2016 Nov – Dec;10(6):480-484. doi: 10.1016/j.jcct.2016.08.004.

  1. A Previously Healthy Premature Infant Treated With Thrombolytic Therapy for Life-threatening Pulmonary Artery Thrombosis.

Ulubas Isik D, Celik IH, Yilmaz O, Bas AY, Demirel N.

J Pediatr Hematol Oncol. 2016 Nov;38(8):e319-e321.

  1. Measuring cardiac output in children undergoing cardiac catheterization: comparison between the Fick method and PRAM (pressure recording analytical method).

Alonso-Iñigo JM, Escribá FJ, Carrasco JI, Fas MJ, Argente P, Galvis JM, Llopis JE.

Paediatr Anaesth. 2016 Nov;26(11):1097-1105. doi: 10.1111/pan.12997.

  1. Isolated Left Subclavian Artery From the Pulmonary Artery Masked by Pulmonary Hypertension.

McVadon D, Shakti D, Knudson J, Dodge-Khatami A, Batlivala SP.

World J Pediatr Congenit Heart Surg. 2016 Nov;7(6):765-768.

  1. Novel delivery technique for atrial septal defect closure in young children utilizing the GORE® CARDIOFORM® septal occluder.

Anderson JH, Fraint H, Moore P, Cabalka AK, Taggart NW.

Catheter Cardiovasc Interv. 2016 Nov 29. doi: 10.1002/ccd.26874. [Epub ahead of print]

  1. Clinical evaluation of a radio-protective cream for the hands of the pediatric interventional cardiologist.

Subramanian S, Waller BR, Winders N, Bird LE, Agrawal V, Zurakowski D, Kuhls-Gilcrist A, Khandkar A, Sathanandam SK.

Catheter Cardiovasc Interv. 2016 Nov 26. doi: 10.1002/ccd.26845. [Epub ahead of print]

  1. The “Dog Bone Technique” A Novel Easy and Safe Catheter Maneuver for Aortic Arch and Coarctation Stenting.

Kantzis M, Lehner A, Laser KT, Racolta A, Vcasna R, Fischer M, Kececioglu D, Haas NA.

J Interv Cardiol. 2016 Nov 24. doi: 10.1111/joic.12358. [Epub ahead of print]

  1. Transcatheter device closure of postmyocardial infarction ventricular septal defect.

Nie YL, Lin MC, Lin WW, Wang CC, Chen CP, Lin CH, Shyu TC, Quek YW, Jan SL, Fu YC.

J Chin Med Assoc. 2016 Nov 23. pii: S1726-4901(16)30195-2. doi: 10.1016/j.jcma.2016.02.014. [Epub ahead of print]

  1. Utility of Echocardiography in the Assessment of Left Ventricular Diastolic Function and Restrictive Physiology in Children and Young Adults with Restrictive Cardiomyopathy: A Comparative Echocardiography-Catheterization Study.

Ryan TD, Madueme PC, Jefferies JL, Michelfelder EC, Towbin JA, Woo JG, Sahay RD, King EC, Brown R, Moore RA, Grenier MA, Goldstein BH.

Pediatr Cardiol. 2016 Nov 23. [Epub ahead of print]

  1. Reducing Fluoroscopic Radiation Exposure During Endomyocardial Biopsy in Pediatric Transplant Recipients.

Gossett JG, Sammet CL, Agrawal A, Rychlik K, Wax DF.

Pediatr Cardiol. 2016 Nov 23. [Epub ahead of print]

  1. Transcatheter Pulmonary Valve Replacement and Acute Increase in Diastolic Pressure are Associated with Increases in Both Systolic and Diastolic Pulmonary Artery Dimensions.

Callahan R, Bergersen L, Lock JE, Marshall AC.

Pediatr Cardiol. 2016 Nov 23. [Epub ahead of print]

  1. Dissecting aneurysm of the interventricular septum due to rupture of the sinus of Valsalva.

Atiq M, Ali F, Hasan SB.

Cardiol Young. 2016 Nov 22:1-4. [Epub ahead of print]

  1. Are Amplatzer Duct Occluder II Additional Sizes devices dedicated for only smaller children?

Fiszer R, Chojnicki M, Szkutnik M, Haponiuk I, Chodór B, Białkowski J.

EuroIntervention. 2016 Nov 22. pii: EIJ-D-15-00238. doi: 10.4244/EIJ-D-15-00238. [Epub ahead of print]

  1. Percutaneous closure of an aortopulmonary window using Amplatzer Duct Occluder II: Additional Sizes: the first reported case.

Fiszer R, Zbroński K, Szkutnik M.

Cardiol Young. 2016 Nov 21:1-4. [Epub ahead of print]

  1. Altering management decisions with gained anatomical insight from a 3D printed model of a complex ventricular septal defect.

Bhatla P, Mosca RS, Tretter JT.

Cardiol Young. 2016 Nov 21:1-4. [Epub ahead of print]

  1. Atrial Septal Defect Closure with Occlutech® ASD Fenestrated Device in a Child with Severe Pulmonary Hypertension.

Gonzalez-Barlatay F, Fournier A, Raboisson MJ, Dahdah N.

Pediatr Cardiol. 2016 Nov 21. [Epub ahead of print]

  1. Overstepping anatomical hurdles when opening an extremely rudimentary right ventricular outflow tract – greater safety via a hybrid strategy?

Kubicki R, Kroll J, Stiller B, Grohmann J.

EuroIntervention. 2016 Nov 20;12(10):1311. doi: 10.4244/EIJV12I10A215. No abstract available.

  1. Catheter Closure Through a Venous Approach of Patent Ductus Arteriosus in Small Pediatric Patients Using Combined Angiographic and Echocardiographic Guidance.

Thanopoulos BV, Ninios V, Dardas P, Giannopoulos A, Deleanou D, Iancovici S.

Am J Cardiol. 2016 Nov 15;118(10):1558-1562. doi: 10.1016/j.amjcard.2016.08.023.

  1. Interventional VSD-Closure with the Nit-Occlud® Lê VSD-Coil in 110 Patients: Early and Midterm Results of the EUREVECO-Registry.

Haas NA, Kock L, Bertram H, Boekenkamp R, De Wolf D, Ditkivskyy I, Freund MW, Gewillig M, Happel CM, Herberg U, Karthasyan E, Kozlik-Feldmann R, Kretschmar O, Kuzmenko Y, Milanesi O, Mueller G, Pongiglione G, Schubert S, Tarusinov G, Kampmann C.

Pediatr Cardiol. 2016 Nov 15. [Epub ahead of print]

  1. Outcomes of Radiofrequency Perforation for Pulmonary Atresia and Intact Ventricular Septum: A Single-Centre Experience.

Rathgeber S, Auld B, Duncombe S, Hosking MC, Harris KC.

Pediatr Cardiol. 2016 Nov 11. [Epub ahead of print]

  1. Early Complications After Percutaneous Closure of Atrial Septal Defect in Infants with Procedural Weight Less than 15 kg.

Tanghöj G, Odermarsky M, Naumburg E, Liuba P.

Pediatr Cardiol. 2016 Nov 11. [Epub ahead of print]

  1. Stenting of the ductus arteriosus in infants with functionally univentricular heart disease and ductal-dependent pulmonary blood flow: A single-center experience.

Celebi A, Yucel IK, Bulut MO, Kucuk M, Balli S.

Catheter Cardiovasc Interv. 2016 Nov 10. doi: 10.1002/ccd.26796. [Epub ahead of print]

  1. Closure of very large PDA with pulmonary hypertension: Initial clinical case-series with the new Occlutech® PDA occluder.

Lehner A, Ulrich S, Happel CM, Fischer M, Kantzis M, Schulze-Neick I, Haas NA.

Catheter Cardiovasc Interv. 2016 Nov 10. doi: 10.1002/ccd.26856. [Epub ahead of print]

  1. Safety of optical coherence tomography in pediatric heart transplant patients.

Ulrich SM, Lehner A, Birnbaum J, Heckel S, Haas NA, Hakami L, Schramm R, Dalla Pozza R, Fischer M, Kozlik-Feldmann R.

Int J Cardiol. 2016 Nov 9;228:205-208. doi: 10.1016/j.ijcard.2016.11.109. [Epub ahead of print]

  1. Long-Term Outcomes of Balloon Valvuloplasty for Isolated Pulmonary Valve Stenosis.

Devanagondi R, Peck D, Sagi J, Donohue J, Yu S, Pasquali SK, Armstrong AK.

Pediatr Cardiol. 2016 Nov 8. [Epub ahead of print]

  1. Feasibility and Accuracy of Cardiac Right-to-Left-Shunt Detection in Children by New Transpulmonary Ultrasound Dilution Method.

Boehne M, Baustert M, Paetzel V, Boethig D, Köditz H, Dennhardt N, Beerbaum P, Bertram H.

Pediatr Cardiol. 2016 Nov 8. [Epub ahead of print]

  1. Long-term Complications After Transcatheter Atrial Septal Defect Closure: A Review of the Medical Literature.

Jalal Z, Hascoet S, Baruteau AE, Iriart X, Kreitmann B, Boudjemline Y, Thambo JB.

Can J Cardiol. 2016 Nov;32(11):1315.e11-1315.e18. doi: 10.1016/j.cjca.2016.02.068. Review.

  1. Percutaneous coronary artery revascularization procedures in pediatric heart transplant recipients: A large single center experience.

Turner ME, Addonizio LJ, Richmond ME, Zuckerman WA, Vincent JA, Torres AJ, Collins MB.

Catheter Cardiovasc Interv. 2016 Nov;88(5):797-803. doi: 10.1002/ccd.26544.

  1. Pressure-volume-loop-guided closure of an iatrogenic atrial septal defect for right heart failure following MitraClip™-implantation.

von Roeder M, Rommel KP, Blazek S, Daehnert I, Lurz P.

Eur Heart J. 2016 Nov 1;37(41):3153. No abstract available.

  1. The development of a pseudo-chamber after balloon pulmonary angioplasty: long-term complications of balloon pulmonary angioplasty.

Sugiyama H, Kise H, Toda T, Hoshiai M.

Heart Vessels. 2016 Nov;31(11):1889-1893.

  1. Balloon-expandable covered stent implantation for treatment of traumatic aortic pseudoaneurysm in a pediatric patient.

Heal ME, Chowdhury SM, Bandisode VM.

J Thorac Cardiovasc Surg. 2016 Nov;152(5):e109-e111. doi: 10.1016/j.jtcvs.2016.07.022. No abstract available.

  1. Comparison of Transcatheter Atrial Septal Defect Closure in Children, Adolescents and adults: Differences, Challenges and Short-, Mid- and Long-Term Results.

Saritas T, Yucel IK, Demir IH, Demir F, Erdem A, Celebi A.

Korean Circ J. 2016 Nov;46(6):851-861.

  1. Safety and efficacy of transthoracic versus transesophageal echocardiography in transcatheter closure of atrial septal defects. Reporting a single center experience from Saudi Arabia.

Azhar AS.

Saudi Med J. 2016 Nov;37(11):1196-1205. doi: 10.15537/smj.2016.11.15617.

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CHD Surgery Featured Articles of November 2016

Fontan Patient Survival after Pediatric Heart Transplantation has Improved in the Current Era.

Simpson KE, Pruitt E, Kirklin JK, Naftel DC, Singh RK, Edens RE, Barnes AP, Canter CE.

Ann Thorac Surg. 2016 Nov 15. pii: S0003-4975(16)31247-4. doi: 10.1016/j.athoracsur.2016.08.110. [Epub ahead of print]

Take-Home Points:

  1. Early survival of Fontan patients after heart transplant has improved in the current era and is similar to that of non-Fontan CHD patients.
  2. In the current era, Fontan presents are more likely to require inotropic support, have PLE, be younger at time of the Fontan procedure, and have a longer duration between Fontan and transplant.
  3. Risk factors across eras for mortality after transplant include mechanical ventilator support and earlier year of transplant.
  4. Fontan physiology should not be considered a contraindication to heart transplantation.

jeremy-herrmannCommentary by Dr. Jeremy Herrmann (Indianapolis), section editor of congenital heart surgery journal watch:  Simpson and colleagues present a retrospective analysis of the multi-institutional Pediatric Heart Transplant Study evaluating post-heart transplant outcomes in Fontan patients. With other recent studies indicating improving survival of patients with other congenital heart diseases (CHD) and historical data indicating lower survival of Fontan patients following heart transplantation, they aimed to provide a more contemporary evaluation of outcomes in these groups. Including Fontan patients 2 years of age or older who underwent a heart transplant, they analyzed 150 patients in the “early era” (1993-2006) and 252 patients in the “late era” (2007-2014).

When comparing patients between eras, patients from the late era were more likely to have protein-losing enteropathy (PLE), require inotropic support, have a UNOS status 1 listing, be younger at the time of the Fontan procedure (3.31 vs 4.44 years), and have a longer duration between Fontan and transplant (6.71 vs 5.23 years). When comparing congenital heart disease patients with or without Fontan physiology at time of transplant, they observed that patients with Fontan physiology were more likely to have PLE, require inotropic support, be older (10.57 vs 9.04 years) and have a UNOS status 1 listing. For both early and late eras, the time of greatest risk of death was early after transplant. In terms of survival, for Fontan patients the 1-year survival was 77% in the early era and 89% in the late era (Figure 3). Non-Fontan patients exhibited a higher 1-year survival rate in the early era (90%) but were similar in the late era. Multivariate analysis showed that risk factors for death in either era included mechanical ventilator support at time of transplant and earlier year of transplant.

The authors conclude that survival of Fontan patients after heart transplant has improved despite Fontan patients having more comorbidities and overall reduced physical state at time of transplant. Accordingly, simply having Fontan physiology should not be considered a contraindication to heart transplantation.

As this was a retrospective database study, the variables tracked across time were limited in number, and no factors contributing to improved survival could be conclusively identified, though the authors speculate about possible contributing factors (e.g., improved surgical techniques, better perioperative management, etc.).

surg 1

 

Isolated heart transplant and combined heart-liver transplant in adult congenital heart disease patients: Insights from the united network of organ sharing.

Bradley EA, Pinyoluksana KO, Moore-Clingenpeel M, Miao Y, Daniels C.

Int J Cardiol. 2016 Nov 10;228:790-795. doi: 10.1016/j.ijcard.2016.11.121. [Epub ahead of print]

Take-Home Points:

  1. CHD patients have similarly favorable survival outcomes after CHLT compared with non-CHD patients.
  2. CHD patients have worse early but favorable later outcomes after OHT.
  3. More specific tracking of CHD diagnoses within the UNOS system is necessary to appropriately risk-stratify CHD patients with and without underlying liver disease undergoing OHT or CHLT.

Summary:

Commentary by Dr. Jeremy Herrmann (Indianapolis), section editor of congenital heart surgery journal watch:  Bradley and colleagues present an analysis of the UNOS database system evaluating outcomes after isolated orthotopic heart transplant (OHT) and combined heart-liver transplant (CHLT) in adults with or without congenital heart disease (CHD) in the U.S. As the ACHD population continues to grow and as liver dysfunction becomes increasingly recognized in these patients, the questions of how well adult CHD patients survive after OHT and CHLT remain.

The authors queried the UNOS database for OHT and CHLT cases, and patients were identified as having CHD with prior surgery though the underlying CHD diagnoses and previous procedures could not be determined. The authors assumed that the majority of CHD patients who underwent CHLT were likely Fontan patients with liver dysfunction. For OHT, 49,952 procedures were included comprised of patients without CHD (48,985; 66%) or with CHD (967; 60%). The number of OHT procedures remained steady throughout the study period. For CLHT, there were only 164 procedures – 137 (52%) non-CHD and 27 (40%) with CHD. They observed that CHD patients undergo an average of 3-4 CHLT annually since 2010. Interestingly, CHD patients were more likely to undergo CHLT in only 2 of the UNOS regions.

Regardless of transplant type, CHD patients were younger, possessed fewer comorbid diseases (hypertension, diabetes, chronic tobacco use), had lower mean wedge and PA pressures, required less mechanical/inotropic support, and were more likely to have a status 2 listing. Similar findings were observed for CHLT though CHD patients were more likely to have a status I listing.

In terms of survival after OHT, CHD patients had higher early (<1 year) mortality (Figure 2A) but better long-term survival than non-CHD patients who survived beyond 1 year (Figure 2B). For CHLT, there was no difference in early or late survival between groups. Cox proportional hazard regression analysis revealed that previous cardiac surgery was not a risk factor for CHD patients, and that the only risk factor for increased mortality in either group was increased bilirubin level. The presence of CHD was also not a risk factor for reduced survival when comparing OHT and CHLT. The authors conclude that CHD patients had similarly favorable survival outcomes after CHLT compared with non-CHD patients. However, CHD patients had worse early but favorable later outcomes after OHT.

The major limitations of the study include a relatively small number of CHLT patients and a limited number of tracked data points including specific CHD diagnoses for proper risk factor analysis. This study adds to the growing body of literature trying to determine how to risk-stratify liver dysfunction in the CHD population, which is becoming more prevalent. In addition, the issue remains of how to better categorize CHD diagnoses within the UNOS system in order to allow for better outcomes analysis and possibly better listing strategies.

 


CHD Surgery Articles – November 2016

 

  1. Performance of functional fibrinogen thromboelastography in children undergoing congenital heart surgery.

Gautam NK, Cai C, Pawelek O, Rafique MB, Cattano D, Pivalizza EG.

Paediatr Anaesth. 2016 Nov 30. doi: 10.1111/pan.13048. [Epub ahead of print]

  1. Prevalence and Risk Factors for Pericardial Effusions Requiring Readmission After Pediatric Cardiac Surgery.

Elias MD, Glatz AC, O’Connor MJ, Schachtner S, Ravishankar C, Mascio CE, Cohen MS.

Pediatr Cardiol. 2016 Nov 30. [Epub ahead of print]

  1. Extracorporeal Membrane Oxygenation Outcomes After the Comprehensive Stage II Procedure in Patients With Single Ventricles.

Gomez D, Duffy V, Hersey D, Backes C, Rycus P, McConnell P, Voss J, Galantowicz M, Cua CL.

Artif Organs. 2016 Nov 29. doi: 10.1111/aor.12810. [Epub ahead of print]

  1. Situs Inversus Totalis: Single-Stage Anatomic Repair of Complex Congenital Heart Disease.

Chatzis AC, Tsoutsinos AJ, Kanakis MA, Contrafouris CA, Rammos S, Mitropoulos FA.

World J Pediatr Congenit Heart Surg. 2016 Nov 23. pii: 2150135116670631. [Epub ahead of print]

  1. Clinical Assessment of Histidine-Tryptophan-Ketoglutarate Solution and Modified St. Thomas’ Solution in Pediatric Cardiac Surgery of Tetralogy of Fallot.

Wang ZH, An Y, Du MC, Qin TJ, Liu YB, Xu HZ, Yang LQ.

Artif Organs. 2016 Nov 22. doi: 10.1111/aor.12771. [Epub ahead of print]

  1. Towards a Tissue-Engineered Contractile Fontan-Conduit: The Fate of Cardiac Myocytes in the Subpulmonary Circulation.

Biermann D, Eder A, Arndt F, Seoudy H, Reichenspurner H, Mir T, Riso A, Kozlik-Feldmann R, Peldschus K, Kaul MG, Schuler T, Krasemann S, Hansen A, Eschenhagen T, Sachweh JS.

PLoS One. 2016 Nov 22;11(11):e0166963. doi: 10.1371/journal.pone.0166963.

  1. Incidence, risk factors, and outcomes of acute kidney injury in adults undergoing surgery for congenital heart disease.

Kwiatkowski DM, Price E, Axelrod DM, Romfh AW, Han BS, Sutherland SM, Krawczeski CD.

Cardiol Young. 2016 Nov 21:1-8. [Epub ahead of print]

  1. Surgical Repair of Ventricular Septal Defect; Contemporary Results and Risk Factors for a Complicated Course.

Schipper M, Slieker MG, Schoof PH, Breur JM.

Pediatr Cardiol. 2016 Nov 21. [Epub ahead of print]

  1. Outcomes of Tracheostomy in Children Requiring Surgery for Congenital Heart Disease.

Ortmann LA, Manimtim WM, Lachica CI.

Pediatr Cardiol. 2016 Nov 21. [Epub ahead of print]

  1. Tracheostomy Among Infants With Hypoplastic Left Heart Syndrome Undergoing Cardiac Operations: A Multicenter Analysis.

Prodhan P, Agarwal A, ElHassan NO, Bolin EH, Beam B, Garcia X, Gaies M, Tang X.

Ann Thorac Surg. 2016 Nov 16. pii: S0003-4975(16)31253-X. doi: 10.1016/j.athoracsur.2016.09.016. [Epub ahead of print]

  1. Fontan Patient Survival After Pediatric Heart Transplantation Has Improved in the Current Era.

Simpson KE, Pruitt E, Kirklin JK, Naftel DC, Singh RK, Edens RE, Barnes AP, Canter CE.

Ann Thorac Surg. 2016 Nov 15. pii: S0003-4975(16)31247-4. doi: 10.1016/j.athoracsur.2016.08.110. [Epub ahead of print]

  1. Total Anomalous Pulmonary Venous Connection: The Current Management Strategies in A Pediatric Cohort of 768 Patients.

Shi G, Zhu Z, Chen J, Ou Y, Hong H, Nie Z, Zhang H, Liu X, Zheng J, Sun Q, Liu J, Chen H, Zhuang J.

Circulation. 2016 Nov 15. pii: CIRCULATIONAHA.116.023889. [Epub ahead of print]

  1. Repair of anomalous coronary artery from the pulmonary artery: A-signal center 20-year experience.

Qiu J, Li S, Yan J, Wang Q, Song Y, Sun H, Li D.

Int J Cardiol. 2016 Nov 15;223:625-629. doi: 10.1016/j.ijcard.2016.08.221.

  1. Long-Term Follow-Up on Health-Related Quality of Life After Mechanical Circulatory Support in Children.

Fleck TP, Dangel G, Bächle F, Benk C, Grohmann J, Kroll J, Siepe M, Höhn R, Kirschner J, Beyersdorf F, Stiller B.

Pediatr Crit Care Med. 2016 Nov 15. [Epub ahead of print]

  1. Gastrointestinal complications associated with the surgical treatment of heart disease in children.

Ferguson LP, Gandiya T, Kaselas C, Sheth J, Hasan A, Gabra HO.

J Pediatr Surg. 2016 Nov 14. pii: S0022-3468(16)30565-6. doi: 10.1016/j.jpedsurg.2016.10.052. [Epub ahead of print]

  1. Cerebral tissue oxygenation index and lactate at 24 hours postoperative predict survival and neurodevelopmental outcome after neonatal cardiac surgery.

Aly SA, Zurakowski D, Glass P, Skurow-Todd K, Jonas RA, Donofrio MT.

Congenit Heart Dis. 2016 Nov 10. doi: 10.1111/chd.12426. [Epub ahead of print]

  1. Isolated heart transplant and combined heart-liver transplant in adult congenital heart disease patients: Insights from the united network of organ sharing.

Bradley EA, Pinyoluksana KO, Moore-Clingenpeel M, Miao Y, Daniels C.

Int J Cardiol. 2016 Nov 10;228:790-795. doi: 10.1016/j.ijcard.2016.11.121. [Epub ahead of print]

  1. Risk Factors for Acute Kidney Injury after Congenital Cardiac Surgery in Infants and Children: A Retrospective Observational Study.

Park SK, Hur M, Kim E, Kim WH, Park JB, Kim Y, Yang JH, Jun TG, Kim CS.

PLoS One. 2016 Nov 10;11(11):e0166328. doi: 10.1371/journal.pone.0166328.

  1. Anaesthesia management for non-cardiac surgery in children with congenital heart disease.

Yamamoto T, Schindler E.

Anaesthesiol Intensive Ther. 2016 Nov 8. doi: 10.5603/AIT.a2016.0050. [Epub ahead of print]

  1. Mechanical Circulatory Support Devices for Pediatric Patients With Congenital Heart Disease.

Chopski SG, Moskowitz WB, Stevens RM, Throckmorton AL.

Artif Organs. 2016 Nov 8. doi: 10.1111/aor.12760. [Epub ahead of print] Review.

  1. Infant health after heart surgery.
[No authors listed]

Nurs Child Young People. 2016 Nov 8;28(9):19.

  1. Clinical Associations of Early Dysnatremias in Critically Ill Neonates and Infants Undergoing Cardiac Surgery.

Kaufman J, Phadke D, Tong S, Eshelman J, Newman S, Ruzas C, da Cruz EM, Osorio S.

Pediatr Cardiol. 2016 Nov 8. [Epub ahead of print]

  1. Infant health after heart surgery.
[No authors listed]

Nurs Child Young People. 2016 Nov 8;28(9):19.

  1. Genotypic and Phenotypic Predictors of Complete Heart Block and Recovery of Conduction Following Surgical Repair of Congenital Heart Disease.

Murray L, Smith AH, Flack EC, Crum K, Owen J, Kannankeril PJ.

Heart Rhythm. 2016 Nov 5. pii: S1547-5271(16)31011-6. doi: 10.1016/j.hrthm.2016.11.010. [Epub ahead of print]

  1. Minimally invasive approach for coronary artery fistula correction.

Song L, Wang B, Jin J, Hua Z, Yu H, Tao L.

Interact Cardiovasc Thorac Surg. 2016 Nov 3. pii: ivw316. [Epub ahead of print]

  1. Necrotizing Pneumonia Caused by H1N1 Virus in a Child with Total Anomalous Pulmonary Venous Connection after Cardiac Surgery.

Ramoğlu MG, Uçar T, Kendirli T, Eyileten Z, Atalay S.

Acta Cardiol Sin. 2016 Nov;32(6):751-754.

  1. Congenital Heart Surgery Case Mix Across North American Centers and Impact on Performance Assessment.

Pasquali SK, Wallace AS, Gaynor JW, Jacobs ML, O’Brien SM, Hill KD, Gaies MG, Romano JC, Shahian DM, Mayer JE, Jacobs JP.

Ann Thorac Surg. 2016 Nov;102(5):1580-1587. doi: 10.1016/j.athoracsur.2016.04.034.

  1. Prevalence of Noncardiac and Genetic Abnormalities in Neonates Undergoing Cardiac Operations: Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

Patel A, Costello JM, Backer CL, Pasquali SK, Hill KD, Wallace AS, Jacobs JP, Jacobs ML.

Ann Thorac Surg. 2016 Nov;102(5):1607-1614. doi: 10.1016/j.athoracsur.2016.04.008.

  1. Postoperative assessment of left ventricular function by two-dimensional strain (speckle tracking) after paediatric cardiac surgery.

Perdreau E, Séguéla PE, Jalal Z, Perdreau A, Mouton JB, Nelson-Veniard M, Guillet E, Iriart X, Ouattara A, Roubertie F, Mauriat P, Thambo JB.

Arch Cardiovasc Dis. 2016 Nov;109(11):599-606. doi: 10.1016/j.acvd.2016.03.005.

  1. Rescue surgery for neonate with huge rhabdomyoma and left outflow obstruction.

Seki H, Bakhtiary F, Vollroth M, Mohr FW, Kostelka M.

Asian Cardiovasc Thorac Ann. 2016 Nov;24(9):875-877.

  1. Non-invasive measurement of renal perfusion and oxygen metabolism to predict postoperative acute kidney injury in neonates and infants after cardiopulmonary bypass surgery.

Neunhoeffer F, Wiest M, Sandner K, Renk H, Heimberg E, Haller C, Kumpf M, Schlensak C, Hofbeck M.

Br J Anaesth. 2016 Nov;117(5):623-634.

  1. Durability of bioprostheses for the tricuspid valve in patients with congenital heart disease.

Burri M, Vogt MO, Hörer J, Cleuziou J, Kasnar-Samprec J, Kühn A, Lange R, Schreiber C.

Eur J Cardiothorac Surg. 2016 Nov;50(5):988-993.

  1. Nitric oxide administration during paediatric cardiopulmonary bypass: a randomised controlled trial.

James C, Millar J, Horton S, Brizard C, Molesworth C, Butt W.

Intensive Care Med. 2016 Nov;42(11):1744-1752.

  1. Circulating histones for predicting prognosis after cardiac surgery: a prospective study.

Gao H, Zhang N, Lu F, Yu X, Zhu L, Mo X, Wang W.

Interact Cardiovasc Thorac Surg. 2016 Nov;23(5):681-687.

  1. Outcomes in adult congenital heart disease patients undergoing heart transplantation: A systematic review and meta-analysis.

Doumouras BS, Alba AC, Foroutan F, Burchill LJ, Dipchand AI, Ross HJ.

J Heart Lung Transplant. 2016 Nov;35(11):1337-1347. doi: 10.1016/j.healun.2016.06.003.

  1. Operative outcomes of infantile hypertrophic pyloric stenosis in patients with congenital heart disease.

Miyata S, Cho J, Matsushima K, Fowler A, Bliss DW.

J Pediatr Surg. 2016 Nov;51(11):1755-1758. doi: 10.1016/j.jpedsurg.2016.07.002.

  1. Balancing pulmonary blood flow: Theory, in vitro measurements, and clinical correlation of systemic-to-pulmonary shunt banding.

Atlin CR, Haller C, Honjo O, Jegatheeswaran A, Van Arsdell GS.

J Thorac Cardiovasc Surg. 2016 Nov;152(5):1343-1352.e2. doi: 10.1016/j.jtcvs.2016.07.081.

  1. Vasoactive-ventilation-renal score reliably predicts hospital length of stay after surgery for congenital heart disease.

Scherer B, Moser EA, Brown JW, Rodefeld MD, Turrentine MW, Mastropietro CW.

J Thorac Cardiovasc Surg. 2016 Nov;152(5):1423-1429.e1. doi: 10.1016/j.jtcvs.2016.07.070.

  1. Pulmonary valve replacement for congenital heart disease: What valve substitute should we be using?

Mitchell MB.

J Thorac Cardiovasc Surg. 2016 Nov;152(5):1230-1232. doi: 10.1016/j.jtcvs.2016.07.031. No abstract available.

  1. Outcome and performance of bioprosthetic pulmonary valve replacement in patients with congenital heart disease.

Nomoto R, Sleeper LA, Borisuk MJ, Bergerson L, Pigula FA, Emani S, Fynn-Thompson F, Mayer JE, Del Nido PJ, Baird CW.

J Thorac Cardiovasc Surg. 2016 Nov;152(5):1333-1342.e3. doi: 10.1016/j.jtcvs.2016.06.064.

  1. Association of Extracorporeal Membrane Oxygenation Support Adequacy and Residual Lesions With Outcomes in Neonates Supported After Cardiac Surgery.

Howard TS, Kalish BT, Wigmore D, Nathan M, Kulik TJ, Kaza AK, Williams K, Thiagarajan RR.

Pediatr Crit Care Med. 2016 Nov;17(11):1045-1054.

  1. A case of severe perioperative hypoxia in uncorrected tetralogy of fallot: Anesthetic management.

Athar M, Ali S, Ahmed SM, Mazahir R.

Rev Esp Anestesiol Reanim. 2016 Nov;63(9):544-547. doi: 10.1016/j.redar.2016.04.002. English, Spanish.

  1. Continuous Cardiopulmonary Bypass During the Repair of Total Anomalous Pulmonary Venous Return.

Parzen JS, Swartz MF, Cholette JM, Smith F, Gensini F, Alfieris GM.

World J Pediatr Congenit Heart Surg. 2016 Nov;7(6):750-752.

  1. A Comparison of Perioperative Management of Anomalous Aortic Origin of a Coronary Artery Between an Adult and Pediatric Cardiac Center.

Herrmann JL, Goldberg LA, Khan AM, Partington SL, Brothers JA, Mascio CE, Spray TL, Kim YY, Fuller S.

World J Pediatr Congenit Heart Surg. 2016 Nov;7(6):721-726.

  1. Vascular Ring Diagnosis and Management: Notable Trends Over 25 Years.

Evans WN, Acherman RJ, Ciccolo ML, Carrillo SA, Mayman GA, Luna CF, Rollins RC, Castillo WJ, Restrepo H.

World J Pediatr Congenit Heart Surg. 2016 Nov;7(6):717-720.

  1. Three Dimensional Visualization of Human Cardiac Conduction Tissue in Whole Heart Specimens by High-Resolution Phase-Contrast CT Imaging Using Synchrotron Radiation.

Shinohara G, Morita K, Hoshino M, Ko Y, Tsukube T, Kaneko Y, Morishita H, Oshima Y, Matsuhisa H, Iwaki R, Takahashi M, Matsuyama T, Hashimoto K, Yagi N.

World J Pediatr Congenit Heart Surg. 2016 Nov;7(6):700-705.

  1. Surgical Treatment for Double Outlet Right Ventricle With Pulmonary Outflow Tract Obstruction.

Wu Q, Jin Y, Li H, Zhang M.

World J Pediatr Congenit Heart Surg. 2016 Nov;7(6):696-699.

  1. Current Expectations for Cardiac Transplantation in Patients With Congenital Heart Disease.

Kirklin JK, Carlo WF, Pearce FB.

World J Pediatr Congenit Heart Surg. 2016 Nov;7(6):685-695.

  1. Current Status of Tissue Engineering Heart Valve.

Shinoka T, Miyachi H.

World J Pediatr Congenit Heart Surg. 2016 Nov;7(6):677-684.

  1. Post-cardiotomy Rescue Extracorporeal Cardiopulmonary Resuscitation in Neonates with Single Ventricle After Intractable Cardiac Arrest: Attrition After Hospital Discharge and Predictors of Outcome.

Polimenakos AC, Rizzo V, El-Zein CF, Ilbawi MN.

Pediatr Cardiol. 2016 Nov 24. [Epub ahead of print]

  1. Influence of Transplant Center Procedural Volume on Survival Outcomes of Heart Transplantation for Children Bridged with Mechanical Circulatory Support.

Hsieh A, Tumin D, McConnell PI, Galantowicz M, Tobias JD, Hayes D Jr.

Pediatr Cardiol. 2016 Nov 24. [Epub ahead of print]

  1. Clinical Outcomes in Pediatric Patients Hospitalized with Fulminant Myocarditis Requiring Extracorporeal Membrane Oxygenation: A Meta-analysis.

Xiong H, Xia B, Zhu J, Li B, Huang W.

Pediatr Cardiol. 2016 Nov 23. [Epub ahead of print] Review.

  1. Right Ventricular Dysfunction as an Echocardiographic Measure of Acute Rejection Following Heart Transplantation in Children.

Aggarwal S, Blake J, Sehgal S.

Pediatr Cardiol. 2016 Nov 23. [Epub ahead of print]

  1. Long-Term Follow-Up on Health-Related Quality of Life After Mechanical Circulatory Support in Children.

Fleck TP, Dangel G, Bächle F, Benk C, Grohmann J, Kroll J, Siepe M, Höhn R, Kirschner J, Beyersdorf F, Stiller B.

Pediatr Crit Care Med. 2016 Nov 15. [Epub ahead of print]

  1. Preoperative Staphylococcus aureus Carriage and Risk of Surgical Site Infection After Cardiac Surgery in Children Younger than 1 year: A Pilot Cohort Study.

Macher J, Gras Le Guen C, Chenouard A, Liet JM, Gaillard Le Roux B, Legrand A, Mahuet J, Launay E, Gournay V, Joram N.

Pediatr Cardiol. 2016 Nov 14. [Epub ahead of print]

  1. Prediction of Fluid Responsiveness Using Pulse Pressure Variation in Infants Undergoing Ventricular Septal Defect Repair with Median Sternotomy or Minimally Invasive Right Thoracotomy.

Han D, Liu YG, Luo Y, Li J, Ou-Yang C.

Pediatr Cardiol. 2016 Nov 11. [Epub ahead of print]

  1. Alemtuzumab (Campath-1H) therapy for refractory rejections in pediatric heart transplant recipients.

Das B, Dimas V, Guleserian K, Lacelle C, Anton K, Moore L, Morrow R.

Pediatr Transplant. 2016 Nov 11. doi: 10.1111/petr.12844. [Epub ahead of print]

  1. Cerebral tissue oxygenation index and lactate at 24 hours postoperative predict survival and neurodevelopmental outcome after neonatal cardiac surgery.

Aly SA, Zurakowski D, Glass P, Skurow-Todd K, Jonas RA, Donofrio MT.

Congenit Heart Dis. 2016 Nov 10. doi: 10.1111/chd.12426. [Epub ahead of print]

  1. Therapy of acute kidney injury in the perioperative setting.

Romagnoli S, Ricci Z, Ronco C.

Curr Opin Anaesthesiol. 2016 Nov 10. [Epub ahead of print]

  1. Clinical Associations of Early Dysnatremias in Critically Ill Neonates and Infants Undergoing Cardiac Surgery.

Kaufman J, Phadke D, Tong S, Eshelman J, Newman S, Ruzas C, da Cruz EM, Osorio S.

Pediatr Cardiol. 2016 Nov 8. [Epub ahead of print]

  1. Delayed Sternal Closure in Infant Heart Surgery-The Importance of Where and When: An Analysis of the STS Congenital Heart Surgery Database.

Nelson-McMillan K, Hornik CP, He X, Vricella LA, Jacobs JP, Hill KD, Pasquali SK, Alejo DE, Cameron DE, Jacobs ML.

Ann Thorac Surg. 2016 Nov;102(5):1565-1572. doi: 10.1016/j.athoracsur.2016.08.081.

  1. Preoperative and Intraoperative Predictive Factors of Immediate Extubation After Neonatal Cardiac Surgery.

Varghese J, Kutty S, Abdullah I, Hall S, Shostrom V, Hammel JM.

Ann Thorac Surg. 2016 Nov;102(5):1588-1595. doi: 10.1016/j.athoracsur.2016.04.030.

  1. Growing potential of small aortic valve with aortic coarctation or interrupted aortic arch after bilateral pulmonary artery banding.

Fuchigami T, Nishioka M, Akashige T, Higa S, Takahashi K, Nakayashiro M, Nabeshima T, Sashinami A, Sakurai K, Takefuta K, Nagata N.

Interact Cardiovasc Thorac Surg. 2016 Nov;23(5):688-693.

  1. Mechanically assisted Fontan completion: A new approach for the failing Glenn circulation due to isolated ventricular dysfunction.

Adachi I, Williams E, Jeewa A, Elias B, McKenzie ED.

J Heart Lung Transplant. 2016 Nov;35(11):1380-1381. doi: 10.1016/j.healun.2016.09.011. No abstract available.

  1. Kidney Outcomes 5 Years After Pediatric Cardiac Surgery: The TRIBE-AKI Study.

Greenberg JH, Zappitelli M, Devarajan P, Thiessen-Philbrook HR, Krawczeski C, Li S, Garg AX, Coca S, Parikh CR; TRIBE-AKI Consortium..

JAMA Pediatr. 2016 Nov 1;170(11):1071-1078. doi: 10.1001/jamapediatrics.2016.1532.

  1. Predicting the Need for Neoaortic Arch Intervention in Infants with Hypoplastic Left Heart Syndrome Through the Glenn Procedure.

Eagam M, Loomba RS, Pelech AN, Tweddell JS, Kirkpatrick E.

Pediatr Cardiol. 2016 Nov 1. [Epub ahead of print]

  1. Interstage Survival for Patients with Hypoplastic Left Heart Syndrome After ECMO.

Fernandez RP, Joy BF, Allen R, Stewart J, Miller-Tate H, Miao Y, Nicholson L, Cua CL.

Pediatr Cardiol. 2016 Nov 1. [Epub ahead of print]

  1. Is Administration of Nitric Oxide During Extracorporeal Membrane Oxygenation Associated With Improved Patient Survival?

Tadphale SD, Rettiganti M, Gossett JM, Beam BW, Padiyath A, Schmitz ML, Gupta P.

Pediatr Crit Care Med. 2016 Nov;17(11):1080-1087.

  1. Risk Adjustment for Congenital Heart Surgery Score as a Risk Factor for Candidemia in Children Undergoing Congenital Heart Defect Surgery.

de Araujo Motta F, Dalla-Costa LM, Dominguez Muro M, Lenzi A, Picharski GL, Burger M.

Pediatr Infect Dis J. 2016 Nov;35(11):1194-1198.

  1. Prevalence and outcomes of heart transplantation in children with intellectual disability.

Wightman A, Bartlett HL, Zhao Q, Smith JM.

Pediatr Transplant. 2016 Nov 1. doi: 10.1111/petr.12839. [Epub ahead of print]

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Pediatric Cardiology Featured Articles of October 2016

Ciliopathy variant burden and developmental delay in children with hypoplastic left heart syndrome.
Geddes GC, Stamm K, Mitchell M, Mussatto KA, Tomita-Mitchell A.
Genet Med. 2016 Oct 27. doi: 10.1038/gim.2016.167. [Epub ahead of print]

Take Home Points

  1. Recent studies have found an association between ciliary dysfunction and the development of congenital heart disease. Other studies have noted the importance of cilia in development of the nervous system in the fetus.
  2. This study from Wisconsin used advanced genetic testing methods to determine the ciliopathy gene variant burden in children with hypoplastic left heart syndrome (HLHS).
  3. The results found that children with HLHS and developmental delay had a higher ciliopathy gene variant burden compared to those with HLHS and no developmental delay.
  4. These findings suggest that ciliary dysfunction may contribute to developmental delay in children with CHD.

Abarbanell picture smallCommentary from Dr. Ginnie Abarbanell (Atlanta), section editor of Pediatric Cardiology Journal Watch: Cilia are often overlooked in congenital cardiology.  Of course we all recognize the role of cilia in the lungs and airways and the association of Kartagener’s syndrome (primary cilia dyskinesia) with situs inversus.  However, recent studies would suggest that ciliary dysfunction may play a crucial role in the etiology of congenital heart disease (CHD) as well as cilia being instrumental in neuronal migration in the fetus. This article from Wisconsin sought to determine if ciliary dysfunction leads to an increased risk for developmental delay in children with CHD.  24 children with hypoplastic left heart syndrome (HLHS) were studied.  All children underwent neurodevelopmental evaluation using the Bayley Scales of Infant Development–III (BSID-III) at a mean age of 19.3 months.  12 children had developmental delay and 12 children had scores within the average range.  Exome sequencing was performed in all 24 children in particular for 14 genes known to be associated with ciliary dysfunction.  The combined annotation-dependent depletion (CADD) method was used to assign a summative “C-score” which “represents the burden of genetic variation” of the ciliopathy genes studied. The summative C-scores were compared between the children with developmental delay to those without developmental delay.  The average summative C-score for the ciliopathy gene list was significantly higher in the children with HLHS and developmental delay compared to the children with HLHS and no developmental delay (4.05 vs. 2.02, empirical P valve <0.01). This study suggests that cilia may play an important role in neurodevelopmental delay in children with CHD and as the authors note “Patients with HLHS and developmental delay have a higher level of disruption in ciliary genes.”

 

Effect of Fontan operation on liver stiffness in children with single ventricle physiology.
DiPaola FW, Schumacher KR, Goldberg CS, Friedland-Little J, Parameswaran A, Dillman JR.
Eur Radiol. 2016 Oct 17. [Epub ahead of print]

Take Home Points

  1. Fontan associated liver disease is a known complication of Fontan palliation.
  2. This study from the University of Michigan demonstrates that liver stiffness and inferior vena cava pressure increase immediately after a Fontan operation.
  3. Ultrasound liver shear wave elastography (SWE) was used to evaluate liver stiffness in this study and may be a useful measurement to follow over time to evaluate for Fontan associated liver disease or Fontan failure.

Commentary from Dr. Ginnie Abarbanell (Atlanta), section editor of Pediatric Cardiology Journal Watch: Fontan associated liver disease is a known complication of Fontan palliation.  This study from the University of Michigan assessed liver stiffness following the Fontan operation:  18 children (mean age 33.5 months) were included in the study.  Children underwent ultrasound shear wave elastography (SWE) pre-operatively and post operatively following Fontan procedure at 24-72 hours, at hospital discharge and at 6 months.  To measure SWE a “focused acoustic radiation force impulse (so-called push pulse)” is generated within the liver.  The push pulse produces shear waves in the liver and the speed of the waves is a measurement of liver stiffness. Researchers found that there was a significant increase in liver stiffness as assessed by SWE following the Fontan procedure (See Figure 3).  Additionally in 9 out of the 18 patients direct IVC measurement pressures could be obtained post operatively from a central venous line. The IVC pressure was significantly increased postoperatively from baseline in these patients.  (See Figure 5).  This small study illustrates that the Fontan operation leads to immediate increases in liver stiffness and IVC pressures that most likely contribute to hepatic congestion leading to longstanding liver disease.  Liver ultrasound SWE may be a useful measurement to follow over time to predict long term clinical outcomes such as Fontan associated liver disease or Fontan failure.

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Comparing First- and Second-Year Palivizumab Prophylaxis in Patients with Hemodynamically Significant Congenital Heart Disease in the CARESS Database (2005-2015).
Li A, Wang DY, Lanctôt KL, Mitchell I, Paes BA; CARESS Investigators.
Pediatr Infect Dis J. 2016 Oct 6. [Epub ahead of print]

Take Home Points

  1. Infants with hemodynamically significant congenital heart disease are at increased risk for hospitalization and mortality with respiratory syncytial virus (RSV) infection compared to healthy infants.
  2. The results of this study indicate that infants with hemodynamically significant CHD are at a similar risk for RSV hospitalization during the second year of life as in the first year of life and may benefit from RSV prophylaxis until age 2.

Commentary from Dr. Ginnie Abarbanell (Atlanta), section editor of Pediatric Cardiology Journal Watch: Within the last two years the American Academy of Pediatrics and the Canadian Paediatric Society guidelines have decreased palivizumab prophylaxis for respiratory syncytial virus (RSV) in hemodynamically significant congenital heart disease (CHD) from up to 2 years of age to only up to 1 year of age.  This change was based on studies that demonstrated a decreased frequency of RSV related hospitalizations in the second year of life.  This study from Ontario, Canada queried the Canadian Registry of Palivizumab (CARESS) to assess whether there were differences in respiratory illness related hospitalizations (RIH) and RSV hospitalizations (RSVH) in children with hemodynamically significant CHD who received palivizumab during the first year of life only compared to those receiving palivizumab until age 2.   1909 infants with hemodynamically significant CHD were include in the analysis with 72.3% (1380) receiving prophylaxis in the first year and 27.7% (529) for 2 years.  Those infants that received prophylaxis for 2 years had a more complicated neonatal course compared to those the received prophylaxis for 1 year only.  The unadjusted rates of RIH and RSVH were lower in those receiving palivizumab between ages 1-2 years. (See Table 3).  However, the adjusted Cox regression analysis demonstrated a similar hazard ratio for RIH and RSVH rates between the two groups.  This indicates that infants with hemodynamically significant CHD are at a similar risk for RSV hospitalization during the second year of life as in the first year of life.  These findings would suggest that certain infants that continue to have hemodynamically significant CHD beyond 1 year of life such as infants with cardiomyopathies and single ventricle physiology may benefit from RSV prophylaxis with palivizumab for 2 years rather than 1 year.

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The Effect of Image Review before Patient Discharge on Study Completeness and Sonographer Job Satisfaction in a Pediatric Echocardiographic Laboratory.
Johnson JT, Robinson JD, Young LT, Camarda JA.
J Am Soc Echocardiogr. 2016 Oct;29(10):1000-1005. doi: 10.1016/j.echo.2016.07.005.

Take Home Points

  1. This quality improvement initiative found an increase in the number of complete echocardiograms performed when the attending cardiologist reviews the images prior to discharge.
  2. Additionally, the physician and sonographer communication and sonographer job satisfaction improved.
  3. The additional time required for the attending physician to review was minimal at a median of 6 minutes.

Commentary from Dr. Ginnie Abarbanell (Atlanta), section editor of Pediatric Cardiology Journal Watch: Completeness of echocardiograms improved in this study from Chicago when the attending cardiologist reviewed the images prior to discharge.  In this quality improvement initiative 63 echocardiograms were performed and reviewed by the attending physician prior to discharge and compared to 63 control echocardiograms performed prior to the quality improvement project.  The percentage of complete echocardiograms performed improved from 65% in the control group compared to the 94% in the quality improvement group.  The study time (including review and acquisition of additional images) added a median of 6 minutes per study (range, 1-28 minutes).  A survey of the sonographers regarding the QI imitative found that 64% of sonographers believed the pre-discharge review positively impacted communication and 50% noted an improvement in job satisfaction.  Additional sonographer comments included “that real-time review improved their effort, improved their educational interactions with the attending physician, and created an environment that kept the sonographer at the top of their performance.”

 

High on Aspirin Platelet Reactivity in Pediatric Patients Undergoing the Fontan Procedure.
Patregnani J, Klugman D, Zurakowski D, Sinha P, Freishtat R, Berger J, Diab Y.
Circulation. 2016 Oct 25;134(17):1303-1305. No abstract available.

Take Home Points

  1. Despite the recommended aspirin thromboprophylaxis after the Fontan procedure, 21% of patients still develop thromboembolism.
  2. Suboptimal inhibition of ex vivo platelet function in response to aspirin referred to as high on aspirin platelet reactivity (HAPR).
  3. Half of the post Fontan patients demonstrated HAPR by thromboelastography with platelet mapping (TEG-PM) and 30% had no response to aspirin (%AA inhibition = 0%).
  4. High on aspirin platelet reactivity (HAPR) is common in postoperative Fontan patients and may contribute to aspirin prophylaxis failure.

Shaji Menon Portrait 12.15.14Commentary from Dr. Shaji Menon (Salt Lake City), section editor of Pediatric Cardiology Journal Watch: Thromboembolic complication are common after surgical palliation in single ventricle patients. Aspirin is the most commonly used medication for thromboembolic prophylaxis in patients with single ventricle physiology.  This study evaluate the prevalence of high on aspirin platelet reactivity (HAPR) thromboelastography with platelet mapping (TEG-PM) in 20 patients undergoing the Fontan procedure between 2014 and 2015. Thromboelastography with platelet mapping (TEG-PM), and a urine sample was collected for urine 11-dehydro-thromboxane B2 (11-dTXB2) testing. In 20 study patients and 9 healthy controls.  All study patients were on 5 mg per kg per day of aspirin for 5 days before blood and urine testing was performed. Of the 20 Fontan patients included in this study, 50% demonstrated HAPR by thromboelastography with platelet mapping (TEG-PM) and 30% had  no response to aspirin (%AA inhibition = 0%). One of these 3 patients had an embolic stroke.  Fontan patients without HAPR demonstrated a significant 50% median Urine 11-dTXB2.  However, Urine 11-dTXB2 did not significantly decrease with aspirin therapy in patients with HAPR.

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The importance of early involvement of paediatric palliative care for patients with severe congenital heart disease.
Bertaud S, Lloyd DF, Laddie J, Razavi R.
Arch Dis Child. 2016 Oct;101(10):984-7. doi: 10.1136/archdischild-2015-309789. Review.

Take Home Points

  1. Referral and involvement of pediatric palliative care services have traditionally been limited to patients with severe congenital heart disease with a low likelihood of survival.
  2. With improved survival and increasing number of patients with severe congenital heart disease, more families have to deal with multiple procedures and prolonged hospitalizations that is often a source of great apprehension and uncertainty for the family.
  3. Earlier referral and involvement of palliative care would enable stronger support for children and their families, facilitating improved symptom control and better informed decision-making, as well as allowing families to accept, plan and prepare for the possibility of death.

Commentary from Dr. Shaji Menon (Salt Lake City), section editor of Pediatric Cardiology Journal Watch: This review article discusses the importance of early involvement of pediatric palliative care for patients with severe congenital heart disease.  Palliative care should not just be considered at end of life but it should be conceptualized as part of the care paradigm.  Involvement of palliative care does not conflict with delivering concomitant therapies that may promote long-term survival or cure the condition.  Palliative care services, both specialized and general, have the potential to enhance the ability of families with complex congenital heart disease children to make better informed decisions and reduce family strain.

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Three-dimensional echocardiography in congenital heart disease: an expert consensus document from the European Association of Cardiovascular Imaging and the American Society of Echocardiography.
Simpson J, Lopez L, Acar P, Friedberg M, Khoo N, Ko H, Marek J, Marx G, McGhie J, Meijboom F, Roberson D, Van den Bosch A, Miller O, Shirali G.
Eur Heart J Cardiovasc Imaging. 2016 Oct;17(10):1071-97. doi: 10.1093/ehjci/jew172.

Commentary from Dr. Shaji Menon (Salt Lake City), section editor of Pediatric Cardiology Journal Watch: This review article provides a comprehensive account of application of 3D echocardiogram in congenital heart disease including technical considerations, image orientation, the use of 3D echocardiogram in different lesions, procedural guidance and functional assessment.

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Computational modelling for congenital heart disease: how far are we from clinical translation?
Biglino G, Capelli C, Bruse J, Bosi GM, Taylor AM, Schievano S.
Heart. 2016 Oct 25. pii: heartjnl-2016-310423. doi: 10.1136/heartjnl-2016-310423. [Epub ahead of print] Review.

Take Home Points from Dr. Shaji Menon (Salt Lake City), section editor of Pediatric Cardiology Journal Watch:

  1. Computational models of congenital heart disease (CHD) are increasingly becoming more robust and sophisticated. These computational complex flow models have been shown to provide patient specific predictive data for surgical repair or catheter interventions before the procedure is actually performed.
  2. Computational models have been used in designing conduits in Fontan procedures to reduce or eliminate pulmonary AV malformations and improve mechanical efficiency of a Fontan circuit. They can also be used for virtual stent placements and design development of medical devices.
  3. Newer models can include multiple patient specific data like varying cardiac outputs into these complex computational models.
  4. Although there is anecdotal evidence for the utility of computational models, there is lack of large validation studies, cost-effectiveness evaluation and establishing possible improvements in patient outcomes.

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Pediatric Cardiology Articles – October 2016

 

  1. Ventricular function and ventriculo-arterial coupling after palliation of hypoplastic left heart syndrome: A comparative study with Fontan patients with LV morphology.

Logoteta J, Ruppel C, Hansen JH, Fischer G, Becker K, Kramer HH, Uebing A.

Int J Cardiol. 2016 Oct 29. pii: S0167-5273(16)33284-3. doi: 10.1016/j.ijcard.2016.10.076. [Epub ahead of print]

 

  1. Ciliopathies.

Braun DA, Hildebrandt F.

Cold Spring Harb Perspect Biol. 2016 Oct 28. pii: a028191. doi: 10.1101/cshperspect.a028191. [Epub ahead of print]

 

  1. Constitutional 560.49 kb chromosome 2p24.3 duplication including the MYCN gene identified by SNP chromosome microarray analysis in a child with multiple congenital anomalies and bilateral Wilms tumor.

Micale MA, Embrey B 4th, Macknis JK, Harper CE, Aughton DJ.

Eur J Med Genet. 2016 Oct 27. pii: S1769-7212(16)30119-7. doi: 10.1016/j.ejmg.2016.10.010. [Epub ahead of print]

 

  1. Ciliopathy variant burden and developmental delay in children with hypoplastic left heart syndrome.

Geddes GC, Stamm K, Mitchell M, Mussatto KA, Tomita-Mitchell A.

Genet Med. 2016 Oct 27. doi: 10.1038/gim.2016.167. [Epub ahead of print]

 

  1. The impact of MYH6 variants in hypoplastic left heart syndrome.

Tomita-Mitchell A, Stamm KD, Mahnke DK, Kim MS, Hidestrand PM, Liang HL, Goetsch MA, Hidestrand M, Simpson PM, Pelech AN, Tweddell JS, Benson DW, Lough JW, Mitchell ME.

Physiol Genomics. 2016 Oct 27:physiolgenomics.00091.2016. doi: 10.1152/physiolgenomics.00091.2016. [Epub ahead of print]

 

  1. Comparison of 128-Slice Low-Dose Prospective ECG-Gated CT Scanning and Trans-Thoracic Echocardiography for the Diagnosis of Complex Congenital Heart Disease.

Bu G, Miao Y, Bin J, Deng S, Liu T, Jiang H, Chen W.

PLoS One. 2016 Oct 27;11(10):e0165617. doi: 10.1371/journal.pone.0165617.

 

  1. Genetic Variants in Isolated Ebstein Anomaly Implicated in Myocardial Development Pathways.

Sicko RJ, Browne ML, Rigler SL, Druschel CM, Liu G, Fan R, Romitti PA, Caggana M, Kay DM, Brody LC, Mills JL.

PLoS One. 2016 Oct 27;11(10):e0165174. doi: 10.1371/journal.pone.0165174.

 

  1. High on Aspirin Platelet Reactivity in Pediatric Patients Undergoing the Fontan Procedure.

Patregnani J, Klugman D, Zurakowski D, Sinha P, Freishtat R, Berger J, Diab Y.

Circulation. 2016 Oct 25;134(17):1303-1305. No abstract available.

 

  1. Computational modelling for congenital heart disease: how far are we from clinical translation?

Biglino G, Capelli C, Bruse J, Bosi GM, Taylor AM, Schievano S.

Heart. 2016 Oct 25. pii: heartjnl-2016-310423. doi: 10.1136/heartjnl-2016-310423. [Epub ahead of print] Review.

 

  1. Cardiovascular risk factor screening and management of obese patients at an outpatient pediatric cardiology center.

Greco M, Sood A, Kwon S, Ariza AJ.

Springerplus. 2016 Oct 24;5(1):1868.

 

  1. Stem cell therapies for congenital heart disease.

Ghafarzadeh M, Namdari M, Eatemadi A.

Biomed Pharmacother. 2016 Oct 22;84:1163-1171. doi: 10.1016/j.biopha.2016.10.055. [Epub ahead of print] Review.

 

  1. Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia.

Chao CM, Yahya F, Moiseenko A, Tiozzo C, Shrestha A, Ahmadvand N, El Agha E, Quantius J, Dilai S, Kheirollahi V, Jones M, Wilhem J, Carraro G, Ehrhardt H, Zimmer KP, Barreto G, Ahlbrecht K, Morty RE, Herold S, Abellar RG, Seeger W, Schermuly R, Zhang JS, Minoo P, Bellusci S.

J Pathol. 2016 Oct 22. doi: 10.1002/path.4834. [Epub ahead of print]

 

  1. Clinical phenotype and current diagnostic criteria for primary ciliary dyskinesia.

Dehlink E, Hogg C, Carr SB, Bush A.

Expert Rev Respir Med. 2016 Oct 19:1-13. [Epub ahead of print]

 

  1. Cardiogenic unilateral pulmonary oedema in an infant with severe residual mitral regurgitation.

Joong A, Lai WW, Ferris A.

Cardiol Young. 2016 Oct 17:1-3. [Epub ahead of print]

 

  1. Effect of Fontan operation on liver stiffness in children with single ventricle physiology.

DiPaola FW, Schumacher KR, Goldberg CS, Friedland-Little J, Parameswaran A, Dillman JR.

Eur Radiol. 2016 Oct 17. [Epub ahead of print]

 

  1. Diagnostic performance and reference values of novel biomarkers of paediatric heart failure.

Hauser JA, Demyanets S, Rusai K, Goritschan C, Weber M, Panesar D, Rindler L, Taylor AM, Marculescu R, Burch M, Wojta J, Michel-Behnke I.

Heart. 2016 Oct 15;102(20):1633-9. doi: 10.1136/heartjnl-2016-309460.

 

  1. Effects of eHealth physical activity encouragement in adolescents with complex congenital heart disease: The PReVaiL randomized clinical trial.

Klausen SH, Andersen LL, Søndergaard L, Jakobsen JC, Zoffmann V, Dideriksen K, Kruse A, Mikkelsen UR, Wetterslev J.

Int J Cardiol. 2016 Oct 15;221:1100-6. doi: 10.1016/j.ijcard.2016.07.092.

 

  1. The benefits and harms of rheumatic heart disease screening from the perspective of the screened population.

Gurney J, Chong A, Culliford-Semmens N, Tilton E, Wilson NJ, Sarfati D.

Int J Cardiol. 2016 Oct 15;221:734-40. doi: 10.1016/j.ijcard.2016.07.025.

 

  1. Uric acid bladder stones in congenital cyanotic heart disease.

Shah A, Keir M, Ducas R, Crean AM.

Lancet. 2016 Oct 15;388(10054):1921. doi: 10.1016/S0140-6736(16)00347-0. No abstract available.

 

  1. The Association between Sex and Long-Term Pediatric Cardiovascular Morbidity.

Sheiner E, Wainstock T, Landau D, Walfisch A.

J Pediatr. 2016 Oct 13. pii: S0022-3476(16)30924-6. doi: 10.1016/j.jpeds.2016.09.014. [Epub ahead of print]

 

  1. Cerebral oxygen saturation during the first 72h after birth in infants diagnosed prenatally with congenital heart disease.

Mebius MJ, van der Laan ME, Verhagen EA, Roofthooft MT, Bos AF, Kooi EM.

Early Hum Dev. 2016 Oct 11;103:199-203. doi: 10.1016/j.earlhumdev.2016.10.001. [Epub ahead of print]

 

  1. Rare association of anophthalmia, complex congenital heart disease and pulmonary hypertension: case report.

Ríos-Méndez RE, Lozano Chinga MM.

Medwave. 2016 Oct 7;16(9):e6568. doi: 10.5867/medwave.2016.09.6568. Spanish, English.

 

  1. Multidetector Computed Tomographic Angiography Imaging of Congenital Pulmonary Venous Anomalies: A Pictorial Review.

Türkvatan A, Güzeltaş A, Tola HT, Ergül Y.

Can Assoc Radiol J. 2016 Oct 6. pii: S0846-5371(16)30040-7. doi: 10.1016/j.carj.2016.05.003. [Epub ahead of print] Review.

 

  1. Non-invasive inhaled nitric oxide in the treatment of hypoxemic respiratory failure in term and preterm infants.

Sahni R, Ameer X, Ohira-Kist K, Wung JT.

J Perinatol. 2016 Oct 6. doi: 10.1038/jp.2016.164. [Epub ahead of print]

 

  1. An unusual migratory polycyclic eruption after administration of prostaglandin E in a neonate.

Young GJ, Harter N, Luu M.

JAAD Case Rep. 2016 Oct 6;2(5):377-379. No abstract available.

 

  1. Comparing First- and Second-Year Palivizumab Prophylaxis in Patients with Hemodynamically Significant Congenital Heart Disease in the CARESS Database (2005-2015).

Li A, Wang DY, Lanctôt KL, Mitchell I, Paes BA; CARESS Investigators..

Pediatr Infect Dis J. 2016 Oct 6. [Epub ahead of print]

 

  1. Bilateral congenital coronary ostial obstruction: Exertional syncope in an otherwise healthy 8-year-old.

Sharma K, Thankavel P.

Echocardiography. 2016 Oct 4. doi: 10.1111/echo.13393. [Epub ahead of print]

 

  1. Clinical and molecular analyses of Beckwith-Wiedemann syndrome: Comparison between spontaneous conception and assisted reproduction techniques.

Tenorio J, Romanelli V, Martin-Trujillo A, Fernández GM, Segovia M, Perandones C, Pérez Jurado LA, Esteller M, Fraga M, Arias P, Gordo G, Dapía I, Mena R, Palomares M, Pérez de Nanclares G, Nevado J, García-Miñaur S, Santos-Simarro F, Martinez-Glez V, Vallespín E; SOGRI Consortium., Monk D, Lapunzina P.

Am J Med Genet A. 2016 Oct;170(10):2740-9. doi: 10.1002/ajmg.a.37852.

 

  1. Gain-of-function mutations in SMAD4 cause a distinctive repertoire of cardiovascular phenotypes in patients with Myhre syndrome.

Lin AE, Michot C, Cormier-Daire V, L’Ecuyer TJ, Matherne GP, Barnes BH, Humberson JB, Edmondson AC, Zackai E, O’Connor MJ, Kaplan JD, Ebeid MR, Krier J, Krieg E, Ghoshhajra B, Lindsay ME.

Am J Med Genet A. 2016 Oct;170(10):2617-31. doi: 10.1002/ajmg.a.37739.

 

  1. The importance of early involvement of paediatric palliative care for patients with severe congenital heart disease.

Bertaud S, Lloyd DF, Laddie J, Razavi R.

Arch Dis Child. 2016 Oct;101(10):984-7. doi: 10.1136/archdischild-2015-309789. Review.

 

  1. The evolving role of cardiac magnetic resonance imaging in the assessment of cardiovascular disease.

Stokes MB, Nerlekar N, Moir S, Teo KS.

Aust Fam Physician. 2016 Oct;45(10):761-764.

 

  1. EUROmediCAT signal detection: an evaluation of selected congenital anomaly-medication associations.

Given JE, Loane M, Luteijn JM, Morris JK, de Jong van den Berg LT, Garne E, Addor MC, Barisic I, de Walle H, Gatt M, Klungsoyr K, Khoshnood B, Latos-Bielenska A, Nelen V, Neville AJ, O’Mahony M, Pierini A, Tucker D, Wiesel A, Dolk H.

Br J Clin Pharmacol. 2016 Oct;82(4):1094-109. doi: 10.1111/bcp.12947.

 

  1. Echocardiographic Tests of Left Ventricular Function in Pediatric Cardiology: Are We Searching for the Holy Grail?

Sandor GG.

Can J Cardiol. 2016 Oct;32(10):1186-1192. doi: 10.1016/j.cjca.2015.10.031.

 

  1. The impact and efficacy of routine pulse oximetry screening for CHD in a local hospital.

Jones AJ, Howarth C, Nicholl R, Mat-Ali E, Knowles R.

Cardiol Young. 2016 Oct;26(7):1397-405. doi: 10.1017/S1047951115002784.

 

  1. The burden of Fallot’s tetralogy among Nigerian children.

Animasahun BA, Madise-Wobo AD, Falase BA, Omokhodion SI.

Cardiovasc Diagn Ther. 2016 Oct;6(5):453-458.

 

  1. New guidelines for managing pulmonary hypertension: what the pediatrician needs to know.

Abman SH.

Curr Opin Pediatr. 2016 Oct;28(5):597-606. doi: 10.1097/MOP.0000000000000403.

 

  1. Advances in pediatric cardiac MRI.

Banka P, Geva T.

Curr Opin Pediatr. 2016 Oct;28(5):575-83. doi: 10.1097/MOP.0000000000000400.

 

  1. Attention deficit hyperactivity disorder medications in children with heart disease.

Berger S.

Curr Opin Pediatr. 2016 Oct;28(5):607-12. doi: 10.1097/MOP.0000000000000388.

 

  1. Oral health among children with congenital heart defects in Western Norway.

Sivertsen TB, Aßmus J, Greve G, Åstrøm AN, Skeie MS.

Eur Arch Paediatr Dent. 2016 Oct;17(5):397-406.

 

  1. Three-dimensional echocardiography in congenital heart disease: an expert consensus document from the European Association of Cardiovascular Imaging and the American Society of Echocardiography.

Simpson J, Lopez L, Acar P, Friedberg M, Khoo N, Ko H, Marek J, Marx G, McGhie J, Meijboom F, Roberson D, Van den Bosch A, Miller O, Shirali G.

Eur Heart J Cardiovasc Imaging. 2016 Oct;17(10):1071-97. doi: 10.1093/ehjci/jew172.

 

  1. Clinical impact of left ventricular eccentricity index using cardiac MRI in assessment of right ventricular hemodynamics and myocardial fibrosis in congenital heart disease.

Yamasaki Y, Nagao M, Kamitani T, Yamanouchi T, Kawanami S, Yamamura K, Sakamoto I, Yabuuchi H, Honda H.

Eur Radiol. 2016 Oct;26(10):3617-25. doi: 10.1007/s00330-015-4199-9.

 

  1. Genetic analyses in a cohort of children with pulmonary hypertension.

Levy M, Eyries M, Szezepanski I, Ladouceur M, Nadaud S, Bonnet D, Soubrier F.

Eur Respir J. 2016 Oct;48(4):1118-1126. doi: 10.1183/13993003.00211-2016.

 

  1. Clinical manifestations in primary ciliary dyskinesia: systematic review and meta-analysis.

Goutaki M, Meier AB, Halbeisen FS, Lucas JS, Dell SD, Maurer E, Casaulta C, Jurca M, Spycher BD, Kuehni CE.

Eur Respir J. 2016 Oct;48(4):1081-1095. doi: 10.1183/13993003.00736-2016.

 

  1. Contemporary imaging following atrial redirection surgery for transposition of the great arteries.

Morrison ML, Lockhart CJ, Grant B.

Heart. 2016 Oct 1;102(19):1551. doi: 10.1136/heartjnl-2016-309602.

 

  1. The Burden of Care: Mothers’ Experiences of Children with Congenital Heart Disease.

Sabzevari S PhD, Nematollahi M PhD Candidate, Mirzaei T PhD, Ravari A PhD.

Int J Community Based Nurs Midwifery. 2016 Oct;4(4):374-385.

 

  1. Liver stiffness modifications shortly after total cavopulmonary connection.

Deorsola L, Aidala E, Cascarano MT, Valori A, Agnoletti G, Pace Napoleone C.

Interact Cardiovasc Thorac Surg. 2016 Oct;23(4):513-8. doi: 10.1093/icvts/ivw186.

 

  1. Laparoscopy Is Safe in Infants and Neonates with Congenital Heart Disease: A National Study of 3684 Patients.

Kim J, Sun Z, Englum BR, Allori AC, Adibe OO, Rice HE, Tracy ET.

J Laparoendosc Adv Surg Tech A. 2016 Oct;26(10):836-839.

 

  1. Modifiers of stress related to timing of diagnosis in parents of children with complex congenital heart disease.

Pinto NM, Weng C, Sheng X, Simon K, Byrne JB, Miller T, Puchalski MD.

J Matern Fetal Neonatal Med. 2016 Oct;29(20):3340-6. doi: 10.3109/14767058.2015.1125465.

 

  1. Novel myosin-based therapies for congenital cardiac and skeletal myopathies.

Ochala J, Sun YB.

J Med Genet. 2016 Oct;53(10):651-4. doi: 10.1136/jmedgenet-2016-103881. Review.

 

  1. Readmissions for Heart Failure in Children.

Moffett BS, Humlicek TJ, Rossano JW, Price JF, Cabrera AG.

J Pediatr. 2016 Oct;177:153-158.e3. doi: 10.1016/j.jpeds.2016.06.003.

 

  1. Neonatal Cyanosis Due to Hemoglobin Variant: Hb F-Sarajevo.

Lozar-Krivec J, Stepic M, Hovnik T, Krsnik M, Paro-Panjan D.

J Pediatr Hematol Oncol. 2016 Oct;38(7):e267-70. doi: 10.1097/MPH.0000000000000655.

 

  1. Predictors of cardio pulmonary resuscitation outcome in postoperative cardiac children.

Nasser BA, Idris J, Mesned AR, Mohamad T, Kabbani MS, Alakfash A.

J Saudi Heart Assoc. 2016 Oct;28(4):244-8. doi: 10.1016/j.jsha.2015.12.002.

 

  1. Does the visibility of a congenital anomaly affect maternal-infant attachment levels?

Boztepe H, Ay A, Kerimoğlu Yıldız G, Çınar S.

J Spec Pediatr Nurs. 2016 Oct;21(4):200-211. doi: 10.1111/jspn.12157.

 

  1. A mixed bag: Differential influences of oxygenation and perfusion on brain development in congenital heart disease.

Rollins CK.

J Thorac Cardiovasc Surg. 2016 Oct;152(4):960-1. doi: 10.1016/j.jtcvs.2016.06.029. No abstract available.

 

  1. Cerebral oxygen delivery is reduced in newborns with congenital heart disease.

Lim JM, Kingdom T, Saini B, Chau V, Post M, Blaser S, Macgowan C, Miller SP, Seed M.

J Thorac Cardiovasc Surg. 2016 Oct;152(4):1095-103. doi: 10.1016/j.jtcvs.2016.05.027.

 

  1. Oral Enoximone as an Alternative to Protracted Intravenous Medication in Severe Pediatric Myocardial Failure.

Furck AK, Bentley S, Bartsota M, Rigby ML, Slavik Z.

Pediatr Cardiol. 2016 Oct;37(7):1297-301. doi: 10.1007/s00246-016-1433-4.

 

  1. Screening for Congenital Heart Disease in Infants with Down Syndrome: Is Universal Echocardiography Necessary?

Bogarapu S, Pinto NM, Etheridge SP, Sheng X, Liesemer KN, Young PC, Saarel EV.

Pediatr Cardiol. 2016 Oct;37(7):1222-7. doi: 10.1007/s00246-016-1419-2.

 

  1. [The clinical feature and microbiological etiology of patients with infective endocarditis].

Li K, Zhang FE, Wang AP, Zhu GF.

Zhonghua Nei Ke Za Zhi. 2016 Oct 1;55(10):774-778. doi: 10.3760/cma.j.issn.0578-1426.2016.10.010. Chinese.

 

  1. Left ventricular hypertrophy in children with previous repair of coarctation of the aorta.

Pamukcu O, Narin N.

Int J Cardiol. 2016 Oct 27. pii: S0167-5273(16)32584-0. doi: 10.1016/j.ijcard.2016.10.044. [Epub ahead of print] No abstract available.

 

  1. Preterm Arteries in Childhood: Dimensions, Intima-Media Thickness and Elasticity of the Aorta, Coronaries and Carotids in 6-year-old Children Born Extremely Preterm.

Mohlkert LA, Hallberg J, Broberg O, Hellström M, Pegelow Halvorsen C, Sjöberg G, Edstedt Bonamy AK, Liuba P, Fellman V, Domellöf M, Norman M.

Pediatr Res. 2016 Oct 27. doi: 10.1038/pr.2016.212. [Epub ahead of print]

 

  1. Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart.

Desai M, Mathur B, Eblimit Z, Vasquez H, Taegtmeyer H, Karpen S, Penny DJ, Moore DD, Anakk S.

Hepatology. 2016 Oct 24. doi: 10.1002/hep.28890. [Epub ahead of print]

 

  1. Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload.

Beetz N, Rommel C, Schnick T, Neumann E, Lother A, Monroy-Ordonez EB, Zeeb M, Preissl S, Gilsbach R, Melchior-Becker A, Rylski B, Stoll M, Schaefer L, Beyersdorf F, Stiller B, Hein L.

J Mol Cell Cardiol. 2016 Oct 24. pii: S0022-2828(16)30388-1. doi: 10.1016/j.yjmcc.2016.10.011. [Epub ahead of print]

 

  1. Increased prevalence of potential right-to-left shunting in children with sickle cell anaemia and stroke.

Dowling MM, Quinn CT, Ramaciotti C, Kanter J, Osunkwo I, Inusa B, Iyer R, Kwiatkowski JL, Johnson C, Rhodes M, Owen W, Strouse JJ, Panepinto JA, Neumayr L, Sarnaik S, Plumb PA, Dlamini N, Kirkham F, Hynan LS; PFAST Investigators..

Br J Haematol. 2016 Oct 21. doi: 10.1111/bjh.14391. [Epub ahead of print]

 

  1. Brain Diffusion Changes in Eisenmenger Syndrome.

Dogan F, Dokumaci DS, Yildirim A, Bozdogan E, Boyaci FN, Koca B, Karakas E.

Br J Radiol. 2016 Oct 21:20151007. [Epub ahead of print]

 

  1. Safety and Efficacy of Terlipressin in Pediatric Distributive Shock: A Retrospective Analysis in 20 Children.

Michel J, Hofbeck M, Spiller G, Renk H, Kumpf M, Neunhoeffer F.

Paediatr Drugs. 2016 Oct 20. [Epub ahead of print]

 

  1. Cardiovascular Profile of Propranolol after Multiple Dosing in Infantile Hemangioma.

Salice P, Giovanni Bianchetti M, Giavarini A, Gondoni E, Cavalli R, Maria Colli A, Lombardi F.

Pharmacology. 2016 Oct 19;99(1-2):75-78. [Epub ahead of print]

 

  1. Do toxic metals and trace elements have a role in the pathogenesis of conotruncal heart malformations?

Kundak AA, Pektas A, Zenciroglu A, Ozdemir S, Barutcu UB, Orun UA, Okumus N.

Cardiol Young. 2016 Oct 18:1-6. [Epub ahead of print]

 

  1. The role of echocardiography in the evaluation of cardiac re-modelling and differentiation between physiological and pathological hypertrophy in teenagers engaged in competitive amateur sports.

Sulovic LS, Mahmutovic M, Lazic S, Sulovic N.

Cardiol Young. 2016 Oct 18:1-7. [Epub ahead of print]

 

  1. Upcoming Events in Pediatric Cardiology.
[No authors listed]

Pediatr Cardiol. 2016 Oct 17. [Epub ahead of print] No abstract available.

 

  1. Persistent reduced myocardial deformation in neonates after CoA repair.

Jashari H, Lannering K, Ibrahimi P, Djekic D, Mellander M, Rydberg A, Henein MY.

Int J Cardiol. 2016 Oct 15;221:886-91. doi: 10.1016/j.ijcard.2016.07.114.

 

  1. Kawasaki disease with giant coronary artery aneurysms.

Hedgire S, Pulli B, Lahoud-Rahme M, Beroukhim RS, Rosales AM, Ghoshhajra B.

Coron Artery Dis. 2016 Oct 14. [Epub ahead of print] No abstract available.

 

  1. NKX2-5 molecular screening and assessment of variant rate and risk factors of secundum atrial septal defect in a Moroccan population.

El Bouchikhi I, Bouguenouch L, Zohra Moufid F, Houssaini MI, Belhassan K, Samri I, Joutei AT, Ouldim K, Atmani S.

Anatol J Cardiol. 2016 Oct 12. doi: 10.14744/AnatolJCardiol.2016.7222. [Epub ahead of print]

 

  1. Neuropsychological functioning in preschool-aged children undergoing evaluation for organ transplant.

Antonini TN, Beer SS, Miloh T, Dreyer WJ, Caudle SE.

Clin Neuropsychol. 2016 Oct 11:1-19. [Epub ahead of print]

 

  1. Cerebral oxygen saturation during the first 72h after birth in infants diagnosed prenatally with congenital heart disease.

Mebius MJ, van der Laan ME, Verhagen EA, Roofthooft MT, Bos AF, Kooi EM.

Early Hum Dev. 2016 Oct 11;103:199-203. doi: 10.1016/j.earlhumdev.2016.10.001. [Epub ahead of print]

 

  1. Risk Factors and Clinical Outcomes in Preterm Infants with Pulmonary Hypertension.

Collaco JM, Dadlani GH, Nies MK, Leshko J, Everett AD, McGrath-Morrow SA.

PLoS One. 2016 Oct 7;11(10):e0163904. doi: 10.1371/journal.pone.0163904.

 

  1. Multidetector Computed Tomographic Angiography Imaging of Congenital Pulmonary Venous Anomalies: A Pictorial Review.

Türkvatan A, Güzeltaş A, Tola HT, Ergül Y.

Can Assoc Radiol J. 2016 Oct 6. pii: S0846-5371(16)30040-7. doi: 10.1016/j.carj.2016.05.003. [Epub ahead of print] Review.

 

  1. Rationale and design of the Children’s Oncology Group (COG) study ALTE1621: a randomized, placebo-controlled trial to determine if low-dose carvedilol can prevent anthracycline-related left ventricular remodeling in childhood cancer survivors at high risk for developing heart failure.

Armenian SH, Hudson MM, Chen MH, Colan SD, Lindenfeld L, Mills G, Siyahian A, Gelehrter S, Dang H, Hein W, Green DM, Robison LL, Wong FL, Douglas PS, Bhatia S.

BMC Cardiovasc Disord. 2016 Oct 4;16(1):187.

 

  1. Pericardial effusion and cardiac tamponade after ventriculoperitoneal shunt placement: a case report.

Wiwattanadittakul N, Katanyuwong K, Jetjumnong C, Sittiwangkul R, Makonkawkeyoon K.

Acta Neurochir (Wien). 2016 Oct;158(10):2019-21. doi: 10.1007/s00701-016-2905-2.

 

  1. Incidence, Severity, and Association With Adverse Outcome of Hyponatremia in Children Hospitalized With Heart Failure.

Price JF, Kantor PF, Shaddy RE, Rossano JW, Goldberg JF, Hagan J, Humlicek TJ, Cabrera AG, Jeewa A, Denfield SW, Dreyer WJ, Akcan-Arikan A.

Am J Cardiol. 2016 Oct 1;118(7):1006-10. doi: 10.1016/j.amjcard.2016.07.014.

 

  1. Does superior caval vein pressure impact head growth in Fontan circulation?

Trachsel T, Balmer C, Wåhlander H, Weber R, Dave H, Poretti A, Kretschmar O, Cavigelli-Brunner A.

Cardiol Young. 2016 Oct;26(7):1327-32. doi: 10.1017/S1047951115002528.

 

  1. New guidelines for managing pulmonary hypertension: what the pediatrician needs to know.

Abman SH.

Curr Opin Pediatr. 2016 Oct;28(5):597-606. doi: 10.1097/MOP.0000000000000403.

 

  1. Advances in pediatric cardiology 2016.

Bernstein D.

Curr Opin Pediatr. 2016 Oct;28(5):573-4. doi: 10.1097/MOP.0000000000000406. No abstract available.

 

  1. Complementary echo and CCTA findings with superior sinus venosus atrial septal defect.

Turner J, Turner MC, Kerut EK.

Echocardiography. 2016 Oct;33(10):1600-1601. doi: 10.1111/echo.13319.

 

  1. Right ventricular global longitudinal strain in repaired tetralogy of Fallot.

Toro KD, Soriano BD, Buddhe S.

Echocardiography. 2016 Oct;33(10):1557-1562. doi: 10.1111/echo.13302.

 

  1. The role of FDG-PET-CT in pediatric cardiac patients and patients with congenital heart defects.

Meyer Z, Fischer M, Koerfer J, Laser KT, Kececioglu D, Burchert W, Ulrich S, Preuss R, Haas NA.

Int J Cardiol. 2016 Oct 1;220:656-60. doi: 10.1016/j.ijcard.2016.06.109. Review.

 

  1. Red blood cell distribution width: can it be a predictive marker for long-term valvular involvement in children with acute rheumatic carditis?

Kucuk M, Ozdemir R, Karadeniz C, Celegen K, Demirol M, Yilmazer MM, Mese T, Unal N.

Int J Lab Hematol. 2016 Oct;38(5):569-75. doi: 10.1111/ijlh.12544.

 

  1. Metabolic consequences of snoring in adolescents and younger adults: a population study in Chile.

Brockmann PE, Damiani F, Smith DL, Castet A, Nuñez F, Villarroel L, Gozal D.

Int J Obes (Lond). 2016 Oct;40(10):1510-1514. doi: 10.1038/ijo.2016.133.

 

  1. The Effect of Image Review before Patient Discharge on Study Completeness and Sonographer Job Satisfaction in a Pediatric Echocardiographic Laboratory.

Johnson JT, Robinson JD, Young LT, Camarda JA.

J Am Soc Echocardiogr. 2016 Oct;29(10):1000-1005. doi: 10.1016/j.echo.2016.07.005.

 

  1. Evaluation of Echocardiographic Measures of Left Ventricular Function in Patients with Duchenne Muscular Dystrophy: Assessment of Reproducibility and Comparison to Cardiac Magnetic Resonance Imaging.

Soslow JH, Xu M, Slaughter JC, Stanley M, Crum K, Markham LW, Parra DA.

J Am Soc Echocardiogr. 2016 Oct;29(10):983-991. doi: 10.1016/j.echo.2016.07.001.

 

  1. Determinants of Pediatric Echocardiography Laboratory Productivity: Analysis from the Second Survey of the American Society of Echocardiography Committee on Echocardiography Laboratory Productivity.

Srivastava S, Allada V, Younoszai A, Lopez L, Soriano BD, Fleishman CE, Van Hoever AM, Lai WW.

J Am Soc Echocardiogr. 2016 Oct;29(10):1009-1015. doi: 10.1016/j.echo.2016.06.007.

 

  1. Elevated Nucleated Red Blood Cells at Birth Predict Hemodynamically Significant Patent Ductus Arteriosus.

Bin-Nun A, Mimouni FB, Fink D, Sela H, Hammerman C.

J Pediatr. 2016 Oct;177:313-5. doi: 10.1016/j.jpeds.2016.07.005.

 

  1. Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial.

Steinhorn RH, Fineman J, Kusic-Pajic A, Cornelisse P, Gehin M, Nowbakht P, Pierce CM, Beghetti M; FUTURE-4 study investigators..

J Pediatr. 2016 Oct;177:90-96.e3. doi: 10.1016/j.jpeds.2016.06.078.

 

  1. Noninvasive Cardiac Output Estimation by Inert Gas Rebreathing in Mechanically Ventilated Pediatric Patients.

Perak AM, Opotowsky AR, Walsh BK, Esch JJ, DiNardo JA, Kussman BD, Porras D, Rhodes J.

J Pediatr. 2016 Oct;177:184-190.e3. doi: 10.1016/j.jpeds.2016.07.007.

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ACHD Featured Articles of October 2016

Eisenmenger syndrome and long-term survival in patients with Down syndrome and congenital heart disease.
Körten MA, Helm PC, Abdul-Khaliq H, Baumgartner H, Kececioglu D, Schlensak C, Bauer UM, Diller GP; Competence Network for Congenital Heart Defects Investigators.
Heart. 2016 Oct 1;102(19):1552-7. doi: 10.1136/heartjnl-2016-309437.

Take Home Points

  1. Patients with Down syndrome (DS) are nearly universally receiving surgical treatment for post-tricuspid shunts in developed countries, in the modern era, and this has resulted in a great reduction in the number of DS patients who have developed Eisenmenger syndrome (ES)
  1. For DS patients with a post-tricuspid shunt, the likelihood of developing ES has decreased from 53% in the 1950s/1960s to 0.5% for patients born between 2000-2009
  1. ES was the only risk factor on multivariable analysis for early mortality in patients with DS and post-tricuspid shunts.
  1. There is a paucity of data regarding outcome of ERA and PDE5 treatment for PAH specific to the DS-ES population.

Kay_William_MD.16.CVa Commentary from Dr. W. Aaron Kay (Indianapolis), section editor of ACHD Journal Watch:  The German National Register is a large database with data on > 46,000 congenital heart disease patients.  The authors reviewed outcomes of all patients with Down Syndrome (DS) and post-tricuspid shunts such as VSD, AVSD, and PDA, to determine the risk of Eisenmenger Syndrome (ES) and to describe long-term mortality, with evaluation based on which patients were offered surgery, as well as surgical era.  They studied outcomes on 894 DS patients with a post-tricuspid shunt.

The likelihood of a DS patient receiving surgical repair before 1 year of age has greatly increased over the past 6 decades; in the 1950s, 0% were offered surgery, 2.1% in the 1970s, and 85.6% of patients born after 2000 were offered surgery. Since surgery is nearly universally offered to DS patients, unless there is a noncardiac contraindication, there has been a decrease in development of ES from 53% for the 1950/1960s birth cohort to 0.5% for the 2000-2009 birth cohort.

Survival at 1, 10, 20, and 40 years for the entire cohort was 96.8%, 94.1%, 92.6%, and 75.5%, with ES being the only risk factor on multivariable analysis for early mortality.

 achd-1
Figure 2 Percentage of patients developing Eisenmenger syndrome by era of birth.

 

achd-2
Figure 4 Survival in Down syndrome by time-dependent survival analysis stratified by the presence of Eisenmenger syndrome and compared with the expected survival of an age-matched and gender-matched sample of the general population.

 

Noninvasive Assessment of Pulmonary Artery Pressure in Patients with Extracardiac Conduit Total Cavopulmonary Connection.
Ajami GH, Mohammadi H, Amirghofran AA, Borzouee M, Amoozgar H, Cheriki S, Edraki MR, Mehdizadegan N, Arabi H, Alvasabi F, Naghshzan A.
Pediatr Cardiol. 2016 Oct;37(7):1361-9. doi: 10.1007/s00246-016-1442-3.

Take Home Points

  1. Elevated pulmonary artery pressure (PAP) is known to correlate with long-term morbidity in single ventricle patients after the Fontan palliation.
  1. Development of reliable noninvasive or minimally invasive measurement of PAP may help improve long-term outcomes of single ventricle patients, and also decrease the need for catheterization, as well as the risks of ionizing radiation, sedation, and embolic risk of catheterization.
  1. A collapsibility index of the IVC (IVC-CI) < 21.8% can predict PAP > 17 mmHg with 83% sensitivity and 100% specificity. Regression equation was developed estimating PAP (mmHg) = 20.2097 – 0.1796 x (IVC-CI), (r2 = 0.56)
  1. Measurement of venous pressure in a peripheral vein, although minimally invasive, correlated well with invasive PAP measurement in this study, with a regression equation estimate being PAP (mmHg) = 0.8675 x PVP (r 0.90, p < 0.0001)
  1. This was a very small study of 19 patients in the pediatric age group, in a region where patients have higher PA pressure than most reports, due to late diagnosis and referral of single ventricle CHD; further studies with larger numbers of patients as well as adult patients may help refine these measurements

Commentary from Dr. W. Aaron Kay (Indianapolis), section editor of ACHD Journal Watch:  This study, from a referral hospital in Iran, sought to evaluate noninvasive and minimally invasive predictors of pulmonary artery pressure (PAP) in a cohort of single ventricle patients, status post extracardiac Fontan.  Of 43 patients who had undergone TCPC at their center over a 10 year period, 19 patients with at least 1-year follow-up were enrolled, mean age 12.9 + 6.6 years with a mean follow-up 3.4 + 1.9 years after Fontan.

All patients underwent cardiac catheterization as well as echocardiographic measurement of inferior vena cava collapsibility index (IVC-CI), as well as measurement of peripheral vein pressure during the cardiac catheterization.  Regression equation estimates were developed, as noted above in the take-home points.  Peripheral venous pressure was higher than mean PAP in all patients.  Of note, all patients with peripheral pressure > 20 mmHg had mean PAP > 17 mmHg.

IVC-CI correlated with mean PAP (r 0.67, p < 0.001).  A cut-off value of IVC-CI < 21.8% had a sensitivity and specificity of 83% and 100%, respectively, for predicting a PAP > 17 mmHg.  Interestingly, an IVC-CI > 21.8% was 100% sensitive for PAP < 17 mmHg.

The authors postulate that it may be helpful to produce a noninvasive measurement of mean PAP prior to making the decision to proceed with cardiac catheterization, and that serial measurements of the IVC-CI could be helpful in long-term follow-up of single ventricle patients.  Additionally, continuous monitoring of peripheral vein pressure and CVP may be more reliable than single-time measurements during catheterization.

achd-3
Fig. 1 Correlation of the peripheral vein pressure and PAP (Correlation coefficient r + 0.90, P<0.0001)

achd-4
Fig. 2 Bland–Altman plot for predicted PAP based on Eq. 1 (PAP (mmHg) = 20.2097-0.1796 9 x (IVC collapsibility index)) versus the measured PAP in catheterization laboratory as the gold standard

 

Recurrent Aortic Dissection: Observations from the International Registry of Aortic Dissection.
Isselbacher EM, Bonaca MP, Di Eusanio M, Froehlich J, Bassone E, Sechtem U, Pyeritz R, Patel H, Khoynezhad A, Eckstein HH, Jondeau G, Ramponi F, Abbasi M, Montgomery D, Nienaber CA, Eagle K, Lindsay ME; International Registry of Aortic Dissection (IRAD) Investigators..
Circulation. 2016 Oct 4;134(14):1013-1024.

Take Home Points

About 5% of aortic dissections are recurrent and recurrent aortic dissections are strongly associated with Marfan syndrome but not bicuspid aortic valve.

jokhadarCommentary from Dr. Maan Jokhadar (Atlanta), section editor of ACHD Journal Watch:  Dr. Isselbacher and colleagues from the International Registry of Aortic Dissection (IRAD) identified 204 patients with recurrent aortic dissection (AD) who were compared with 3624 patients with initial AD. IRAD is a multi-center registry of all cases of acute AD in participating centers.

Important observations can be summarized as follows:

  • Recurrent AD was 8 times more likely in patients with Marfan syndrome but did not occur in bicuspid aortic valve patients.
  • Descending aortic dimensions were greater in patients with recurrent AD with this relationship being accentuated among patients with Marfan syndrome.
  • Patients with recurrent AD who presented with proximal followed by distal AD were younger than patients who experienced distal followed by proximal aortic dissection.
  • About 5% of aortic dissections are recurrent and recurrent AD is strongly associated with Marfan syndrome.
  • Recurrent AD should raise a suspicion of a genetic cause of aortic disease.
  • Recurrent AD was less likely in whites and older patients. Recurrent AD was more likely to involve the descending aorta.
  • Marfan patients represented 3.1% of the initial AD group and 21.5% of the recurrent AD group.
  • The major early AD complications such as stroke, coma, myocardial infarction, and in-hospital death were not significantly different between the recurrent and initial AD groups.
  • Recurrent AD patients tended to be younger patients with more atherosclerosis, more hypertensive, and more aneurysmal disease.

 

Small, unrepaired ventricular septal defects reveal poor exercise capacity compared with healthy peers: A prospective, cohort study.
Maagaard M, Heiberg J, Hjortdal VE.
Int J Cardiol. 2016 Oct 29. pii: S0167-5273(16)33274-0. doi: 10.1016/j.ijcard.2016.10.086. [Epub ahead of print]

Take Home Points
Patients with small, unrepaired ventricular septal defects (VSDs) have a substantially reduced functional capacity, which correlates directly with the patient’s self-perceived physical health.

Commentary from Dr. Maan Jokhadar (Atlanta), section editor of ACHD Journal Watch:  Small-unrepaired VSDs have long thought to be of little hemodynamic or clinical consequence, though some studies have documented increased risk of endocarditis, aortic regurgitation, or ventricular volume overload during long-term follow-up. Exercise performances has apparently never been assessed in unrepaired small VSDs.

Dr. Maagaard and colleagues from Denmark performed upright cycle cardiopulmonary stress tests on 34 asymptomatic young healthy adults with unrepaired VSDs and 28 matched controls (age ~ 26 years). In addition to exercise end-points, health-related quality of life questionnaire was administered to both groups.

The results indicate that young adults with unrepaired small VSDs have significantly reduced peak oxygen consumption (36 ±9 vs. 44 ±6 ml/kg/min), anaerobic threshold (24 ±8 vs. 31 ±7 ml/kg/min), and self-perceived physical health, as compared with healthy matched controls. Limited exercise capacity in unrepaired VSD patients is not easily explained but proposed mechanisms could include abnormal pulmonary vascular response to exercise, and/or increased shunting through the VSD.


ACHD Articles – October 2016

 

  1. Small, unrepaired ventricular septal defects reveal poor exercise capacity compared with healthy peers: A prospective, cohort study.

Maagaard M, Heiberg J, Hjortdal VE.

Int J Cardiol. 2016 Oct 29. pii: S0167-5273(16)33274-0. doi: 10.1016/j.ijcard.2016.10.086. [Epub ahead of print]

 

  1. Usefulness of stroke volume monitoring during upright ramp incremental cycle exercise in young patients with Fontan circulation.

Legendre A, Guillot A, Ladouceur M, Bonnet D.

Int J Cardiol. 2016 Oct 29. pii: S0167-5273(16)33275-2. doi: 10.1016/j.ijcard.2016.10.087. [Epub ahead of print]

 

  1. The Long-Term Management of Children and Adults with a Fontan Circulation: A Systematic Review and Survey of Current Practice in Australia and New Zealand.

Gnanappa GK, Celermajer DS, Sholler GF, Gentles T, Winlaw D, d’Udekem Y, Ayer J.

Pediatr Cardiol. 2016 Oct 27. [Epub ahead of print]

 

  1. MicroRNA-based Therapy of Gata2-deficient Vascular Disease.

Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T.

Circulation. 2016 Oct 25. pii: CIRCULATIONAHA.116.022478. [Epub ahead of print]

 

  1. Ability of noninvasive criteria to predict hemodynamically significant aortic obstruction in adults with coarctation of the aorta.

Astengo M, Berntsson C, Johnsson ÅA, Eriksson P, Dellborg M.

Congenit Heart Dis. 2016 Oct 25. doi: 10.1111/chd.12424. [Epub ahead of print]

 

  1. The role of genetics in pulmonary arterial hypertension.

Ma L, Chung WK.

J Pathol. 2016 Oct 22. doi: 10.1002/path.4833. [Epub ahead of print] Review.

 

  1. Cognitive dysfunction in adult CHD with different structural complexity.

Tyagi M, Fteropoulli T, Hurt CS, Hirani SP, Rixon L, Davies A, Picaut N, Kennedy F, Deanfield J, Cullen S, Newman SP.

Cardiol Young. 2016 Oct 18:1-9. [Epub ahead of print]

 

  1. Risk of Pregnancy in Moderate and Severe Aortic Stenosis: From the Multinational ROPAC Registry.

Orwat S, Diller GP, van Hagen IM, Schmidt R, Tobler D, Greutmann M, Jonkaitiene R, Elnagar A, Johnson MR, Hall R, Roos-Hesselink JW, Baumgartner H; ROPAC Investigators..

J Am Coll Cardiol. 2016 Oct 18;68(16):1727-1737. doi: 10.1016/j.jacc.2016.07.750.

 

  1. Pregnancy and cardiovascular risk: A review focused on women with heart disease undergoing fertility treatment.

Rossberg N, Stangl K, Stangl V.

Eur J Prev Cardiol. 2016 Oct 17. pii: 2047487316673143. [Epub ahead of print] Review.

 

  1. Complications related to surgically constructed septum in adults with congenital heart disease.

Hodgson S, Dehghani P.

Int J Cardiol. 2016 Oct 15;221:839-40. doi: 10.1016/j.ijcard.2016.07.011. No abstract available.

 

  1. A time for greater investment into care for pregnancy and heart disease.

Cauldwell M, Patel R, Steer P, Gatzoulis M.

Int J Cardiol. 2016 Oct 15;221:642-3. doi: 10.1016/j.ijcard.2016.06.292.

 

  1. Recall of patients discharged from follow-up after repair of isolated congenital shunt lesions.

Gabriels C, Van De Bruaene A, Helsen F, Moons P, Van Deyk K, Troost E, Meyns B, Gewillig M, Budts W.

Int J Cardiol. 2016 Oct 15;221:314-20. doi: 10.1016/j.ijcard.2016.07.066.

 

  1. The causes, treatment, and outcome of pulmonary hypertension in Africa: Insights from the Pan African Pulmonary Hypertension Cohort (PAPUCO) Registry.

Thienemann F, Dzudie A, Mocumbi AO, Blauwet L, Sani MU, Karaye KM, Ogah OS, Mbanze I, Mbakwem A, Udo P, Tibazarwa K, Damasceno A, Keates AK, Stewart S, Sliwa K.

Int J Cardiol. 2016 Oct 15;221:205-11. doi: 10.1016/j.ijcard.2016.06.242.

 

  1. Arterial stiffness and arterial function in adult cyanotic patients with congenital heart disease.

Trojnarska O, Szczepaniak-Chicheł L, Gabriel M, Bartczak-Rutkowska A, Rupa-Matysek J, Tykarski A, Grajek S.

J Cardiol. 2016 Oct 15. pii: S0914-5087(16)30212-X. doi: 10.1016/j.jjcc.2016.09.003. [Epub ahead of print]

 

  1. Association of maternal chronic disease with risk of congenital heart disease in offspring.

Chou HH, Chiou MJ, Liang FW, Chen LH, Lu TH, Li CY.

CMAJ. 2016 Oct 11. pii: cmaj.160061. [Epub ahead of print]

 

  1. A clinical combined gadobutrol bolus and slow infusion protocol enabling angiography, inversion recovery whole heart, and late gadolinium enhancement imaging in a single study.

Tandon A, James L, Henningsson M, Botnar RM, Potersnak A, Greil GF, Hussain T.

J Cardiovasc Magn Reson. 2016 Oct 5;18(1):66.17. Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation.

Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E.

Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H944-H957. doi: 10.1152/ajpheart.00040.2016.

 

  1. Health-related quality of life of patients with pulmonary arterial hypertension associated with CHD: the multicentre cross-sectional ACHILLE study.

Amedro P, Basquin A, Gressin V, Clerson P, Jais X, Thambo JB, Guerin P, Cohen S, Bonnet D.

Cardiol Young. 2016 Oct;26(7):1250-9. doi: 10.1017/S1047951116000056.

 

  1. Burden of Heart Failure in Adults with Congenital Heart Disease.

Alshawabkeh LI, Opotowsky AR.

Curr Heart Fail Rep. 2016 Oct;13(5):247-254. Review.

 

  1. [Pulmonary hypertension in grown-ups with congenital heart disease: Recommendations of the Cologne Consensus Conference 2016].

Kaemmerer H, Apitz C, Brockmeier K, Eicken A, Gorenflo M, Hager A, deHaan F, Huntgeburth M, Kozlik-Feldmann R, Miera O, Diller GP.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S70-S79. German.

 

  1. Patients with Down syndrome and congenital heart disease: survival is improving, but challenges remain.

Dimopoulos K, Kempny A.

Heart. 2016 Oct 1;102(19):1515-7. doi: 10.1136/heartjnl-2016-309835. No abstract available.

 

  1. Eisenmenger syndrome and long-term survival in patients with Down syndrome and congenital heart disease.

Körten MA, Helm PC, Abdul-Khaliq H, Baumgartner H, Kececioglu D, Schlensak C, Bauer UM, Diller GP; Competence Network for Congenital Heart Defects Investigators..

Heart. 2016 Oct 1;102(19):1552-7. doi: 10.1136/heartjnl-2016-309437.

 

  1. Submitral aneurysm and the new imaging modalities: Will magnetic resonance imaging be necessary?

Morais H, Manuel V, Costa JC.

Int J Cardiol. 2016 Oct 1;220:833-4. doi: 10.1016/j.ijcard.2016.06.280.

 

  1. Economic burden of venous thromboembolism: Are novel oral anticaoagulants the possible solution?

Zuin M, Picariello C, Badin A, Rinuncini M, Rigatelli G, Zonzin P, Roncon L.

Int J Cardiol. 2016 Oct 1;220:551-2. doi: 10.1016/j.ijcard.2016.06.312. No abstract available.

 

  1. Vagal reactivation after exercise and cardiac autonomic nervous activity in adult Fontan patients without pacemakers.

Eser P, Herzig D, Vogt M, Stämpfli R, Trovato M, Olstad DS, Trachsel L, Deluigi C, Wustmann K, Greutmann M, Tobler D, Stambach D, Schmid JP, Schwerzmann M, Wilhelm M.

Int J Cardiol. 2016 Oct 1;220:527-33. doi: 10.1016/j.ijcard.2016.06.274.

 

  1. Assessment of myocardial function using MRI-based feature tracking in adults after atrial repair of transposition of the great arteries: Reference values and clinical utility.

Tutarel O, Orwat S, Radke RM, Westhoff-Bleck M, Vossler C, Schülke C, Baumgartner H, Bauersachs J, Röntgen P, Diller GP.

Int J Cardiol. 2016 Oct 1;220:246-50. doi: 10.1016/j.ijcard.2016.06.108.

 

  1. Rare Cause of Chest Discomfort and Modest Exercise Intolerance in an Athlete.

Boettcher BT, Makker H, Olund TJ, Pagel PS.

J Cardiothorac Vasc Anesth. 2016 Oct;30(5):1430-4. doi: 10.1053/j.jvca.2016.02.001. No abstract available.

 

  1. Pregnancy in women with cardiovascular disease in the guidelines era: an Italian single-center experience.

Santacesaria S, Cataldo S, Annoni GA, Corbella P, Fiocchi S, Vignati GM.

J Cardiovasc Med (Hagerstown). 2016 Oct;17(10):750-5. doi: 10.2459/JCM.0000000000000352.

 

  1. A retrospective study of judicial encounters of young adults with congenital heart disease.

Malpas TM, George SM, Kaisar JM, Radford DJ.

J Health Psychol. 2016 Oct;21(10):2409-19. doi: 10.1177/1359105315578301.

 

  1. Cardiac image modelling: Breadth and depth in heart disease.

Suinesiaputra A, McCulloch AD, Nash MP, Pontre B, Young AA.

Med Image Anal. 2016 Oct;33:38-43. doi: 10.1016/j.media.2016.06.027.

 

  1. Predictors of Change in Functional Health Status in Adults with Repaired Tetralogy of Fallot.

Lu JC, Yu S, Lowery R, Sagi J, Delong AC, Agarwal PP, Mahani MG, Dorfman AL.

Pediatr Cardiol. 2016 Oct;37(7):1334-9. doi: 10.1007/s00246-016-1439-y.

 

  1. Holodiastolic Flow Reversal at the Descending Aorta on Cardiac Magnetic Resonance is Neither Sensitive Nor Specific for Significant Aortic Regurgitation in Patients with Congenital Heart Disease.

Avitabile CM, Whitehead KK, Fogel MA, Kim DW, Kim TS, Rose JD, Keller MS, Fu GL, Harris MA.

Pediatr Cardiol. 2016 Oct;37(7):1284-9. doi: 10.1007/s00246-016-1430-7.

 

  1. Decline of Systolic and Diastolic 2D Strain Rate During Follow-Up of HLHS Patients After Fontan Palliation.

Michel M, Logoteta J, Entenmann A, Hansen JH, Voges I, Kramer HH, Petko C.

Pediatr Cardiol. 2016 Oct;37(7):1250-7. doi: 10.1007/s00246-016-1424-5.

 

  1. Stroke in Acquired and Congenital Heart Disease Patients and Its Relationship to Hospital Mortality and Lasting Neurologic Deficits.

Cheng HH, Rajagopal S, McDavitt E, Wigmore D, Williams K, Thiagarajan R, Grant PE, Danehy A, Rivkin MJ.

Pediatr Crit Care Med. 2016 Oct;17(10):976-983.

 

  1. Diverse multi-organ histopathologic changes in a failed Fontan patient.

Mizuno M, Ohuchi H, Matsuyama TA, Miyazaki A, Ishibashi-Ueda H, Yamada O.

Pediatr Int. 2016 Oct;58(10):1061-1065. doi: 10.1111/ped.13054.

 

  1. Evaluation of blood flow distribution asymmetry and vascular geometry in patients with Fontan circulation using 4-D flow MRI.

Jarvis K, Schnell S, Barker AJ, Garcia J, Lorenz R, Rose M, Chowdhary V, Carr J, Robinson JD, Rigsby CK, Markl M.

Pediatr Radiol. 2016 Oct;46(11):1507-19. doi: 10.1007/s00247-016-3654-3.

 

  1. Hippocampal volume reduction is associated with intellectual functions in adolescents with congenital heart disease.

Latal B, Patel P, Liamlahi R, Knirsch W, O’Gorman Tuura R, von Rhein M.

Pediatr Res. 2016 Oct;80(4):531-7. doi: 10.1038/pr.2016.122.

 

  1. Editorial Commentary: Looking beyond the heart in adult congenital heart disease.

Bouma BJ, Postma AV.

Trends Cardiovasc Med. 2016 Oct;26(7):637-8. doi: 10.1016/j.tcm.2016.05.002. No abstract available.

 

  1. Extra-cardiac manifestations of adult congenital heart disease.

Gaeta SA, Ward C, Krasuski RA.

Trends Cardiovasc Med. 2016 Oct;26(7):627-36. doi: 10.1016/j.tcm.2016.04.004. Review.

 

  1. Elevated serum HMGB1 in pulmonary arterial hypertension secondary to congenital heart disease.

Huang YY, Su W, Zhu ZW, Tang L, Hu XQ, Zhou SH, Fang ZF, Li J.

Vascul Pharmacol. 2016 Oct;85:66-72. doi: 10.1016/j.vph.2016.08.009.

 

  1. Usefulness of stroke volume monitoring during upright ramp incremental cycle exercise in young patients with Fontan circulation.

Legendre A, Guillot A, Ladouceur M, Bonnet D.

Int J Cardiol. 2016 Oct 29. pii: S0167-5273(16)33275-2. doi: 10.1016/j.ijcard.2016.10.087. [Epub ahead of print]

 

  1. The Long-Term Management of Children and Adults with a Fontan Circulation: A Systematic Review and Survey of Current Practice in Australia and New Zealand.

Gnanappa GK, Celermajer DS, Sholler GF, Gentles T, Winlaw D, d’Udekem Y, Ayer J.

Pediatr Cardiol. 2016 Oct 27. [Epub ahead of print]

 

  1. Sildenafil reduces pulmonary vascular resistance in single ventricular physiology.

Mori H, Park IS, Yamagishi H, Nakamura M, Ishikawa S, Takigiku K, Yasukochi S, Nakayama T, Saji T, Nakanishi T.

Int J Cardiol. 2016 Oct 15;221:122-7. doi: 10.1016/j.ijcard.2016.06.322.

 

  1. Response by Myers and Beghetti to Letter Regarding Article, “Unrestrictive Aortopulmonary Window: Extreme Presentation as Non-Eisenmenger in a 30-Year-Old Patient”.

Myers PO, Beghetti M.

Circulation. 2016 Oct 11;134(15):e330-e331. No abstract available.

 

  1. Recurrent Aortic Dissection: Observations From the International Registry of Aortic Dissection.

Isselbacher EM, Bonaca MP, Di Eusanio M, Froehlich J, Bassone E, Sechtem U, Pyeritz R, Patel H, Khoynezhad A, Eckstein HH, Jondeau G, Ramponi F, Abbasi M, Montgomery D, Nienaber CA, Eagle K, Lindsay ME; International Registry of Aortic Dissection (IRAD) Investigators..

Circulation. 2016 Oct 4;134(14):1013-1024.

 

  1. [Pulmonary hypertension in grown-ups with congenital heart disease: Recommendations of the Cologne Consensus Conference 2016].

Kaemmerer H, Apitz C, Brockmeier K, Eicken A, Gorenflo M, Hager A, deHaan F, Huntgeburth M, Kozlik-Feldmann R, Miera O, Diller GP.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S70-S79. German.

 

  1. [Chronic thromboembolic pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016].

Wilkens H, Konstantinides S, Lang I, Bunck AC, Gerges M, Gerhardt F, Grgic A, Grohé C, Guth S, Held M, Hinrichs J, Hoeper MM, Klepetko W, Kramm T, Krüger U, Lankeit M, Meyer BC, Olsson KM, Schäfers HJ, Schmidt M, Seyfarth HJ, Ulrich S, Wiedenroth CB, Mayer E.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S62-S69. German.

 

  1. [Pulmonary hypertension due to chronic lung disease: Recommendations of the Cologne Consensus Conference 2016].

Olschewski H, Behr J, Bremer H, Claussen M, Douschan P, Halank M, Held M, Hoeper MM, Holt S, Klose H, Krüger S, Lange TJ, Reichenberger F, Skowasch D, Ulrich S, Wilkens H, Seeger W.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S57-S61. German.

 

  1. [Pulmonary hypertension associated with left heart disease: recommendations of the Cologne Consensus Conference 2016].

Rosenkranz S, Lang IM, Blindt R, Bonderman D, Bruch L, Diller GP, Felgendreher R, Gerges C, Hohenforst-Schmidt W, Holt S, Jung C, Kindermann I, Kramer T, Kübler WM, Mitrovic V, Riedel A, Rieth A, Schmeisser A, Wachter R, Weil J, Opitz C.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S48-S56. German.

 

  1. [Decompensated right heart failure, intensive care and perioperative management in patients with pulmonary hypertension].

Olsson KM, Halank M, Egenlauf B, Fistera D, Gall H, Kaehler C, Kortmann K, Kramm T, Lichtblau M, Marra A, Nagel C, Sablotzki A, Seyfarth HJ, Schranz D, Ulrich S, Hoeper MM, Lange TJ.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S42-S47. German.

 

  1. [Targeted therapy of pulmonary arterial hypertension: Recommendations of the Cologne Consensus Conference 2016].

Hoeper MM, Apitz C, Grünig E, Halank M, Ewert R, Kaemmerer H, Kabitz HJ, Kähler C, Klose H, Leuchte H, Ulrich S, Olsson KM, Distler O, Rosenkranz S, Ghofrani HA.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S33-S41. German.

 

  1. [General and supportive therapy of pulmonary arterial hypertension].

Grünig E, Benjamin N, Krüger U, Kaemmerer H, Harutyunova S, Olsson KM, Ulrich S, Gerhardt F, Neurohr C, Sablotzki A, Halank M, Kabitz HJ, Thimm G, Fliegel KG, Klose H.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S26-S32. German.

 

  1. [Risk stratification and follow-up assessment of patients with pulmonary arterial hypertension: Recommendations of the Cologne Consensus Conference 2016].

Leuchte HH, Ten Freyhaus H, Gall H, Halank M, Hoeper MM, Kaemmerer H, Kähler C, Riemekasten G, Ulrich S, Schwaiblmair M, Ewert R.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S19-S25. German.

 

  1. [Clinical classification and initial diagnosis of pulmonary hypertension: recommendations of the Cologne Consensus Conference 2016].

Kovacs G, Dumitrescu D, Barner A, Greiner S, Grünig E, Hager A, Köhler T, Kozlik-Feldmann R, Kruck I, Lammers A, Mereles D, Meyer A, Meyer FJ, Pabst S, Seyfarth HJ, Sinning C, Sorichter S, Stähler G, Wilkens H, Held M.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S10-S18. German.

 

  1. [Pathobiology, pathology and genetics of pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016].

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kübler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S4-S9. German.

 

  1. Assessment of intracardiac flow and vorticity in the right heart of patients after repair of tetralogy of Fallot by flow-sensitive 4D MRI.

Hirtler D, Garcia J, Barker AJ, Geiger J.

Eur Radiol. 2016 Oct;26(10):3598-607. doi: 10.1007/s00330-015-4186-1.

 

  1. Oral Ulcerations Induced by Mycophenolate Mofetil Following Cardiac Transplant.

Mahdavi M, Hejri GM.

Exp Clin Transplant. 2016 Oct;14(5):584-585. No abstract available.

 

  1. Variable severity of cardiovascular phenotypes in patients with an early-onset form of Marfan syndrome harboring FBN1 mutations in exons 24-32.

Maeda J, Kosaki K, Shiono J, Kouno K, Aeba R, Yamagishi H.

Heart Vessels. 2016 Oct;31(10):1717-23. doi: 10.1007/s00380-016-0793-2.

 

  1. Constrictive Pericarditis and Tricuspid Valve Involvement.

Kandachar PS, Kandachar SS, Maddali MM, Thomas E, Zacharias S.

J Cardiothorac Vasc Anesth. 2016 Oct;30(5):1435-6. doi: 10.1053/j.jvca.2016.02.016. No abstract available.

 

  1. The Risk of Thromboembolic Complications in Fontan Patients with Atrial Flutter/Fibrillation Treated with Electrical Cardioversion.

Lin JH, Kean AC, Cordes TM.

Pediatr Cardiol. 2016 Oct;37(7):1351-60. doi: 10.1007/s00246-016-1441-4.

 

  1. Bone-Specific Alkaline Phosphatase in Patients Who Have Undergone the Fontan Operation.

Schiff A, Yang J, Winner LH, Schwartz MC.

Pediatr Cardiol. 2016 Oct;37(7):1370-6. doi: 10.1007/s00246-016-1443-2.

 

  1. Noninvasive Assessment of Pulmonary Artery Pressure in Patients with Extracardiac Conduit Total Cavopulmonary Connection.

Ajami GH, Mohammadi H, Amirghofran AA, Borzouee M, Amoozgar H, Cheriki S, Edraki MR, Mehdizadegan N, Arabi H, Alvasabi F, Naghshzan A.

Pediatr Cardiol. 2016 Oct;37(7):1361-9. doi: 10.1007/s00246-016-1442-3.

 

  1. Predictors of Change in Functional Health Status in Adults with Repaired Tetralogy of Fallot.

Lu JC, Yu S, Lowery R, Sagi J, Delong AC, Agarwal PP, Mahani MG, Dorfman AL.

Pediatr Cardiol. 2016 Oct;37(7):1334-9. doi: 10.1007/s00246-016-1439-y.

 

  1. The Impact of Concomitant Left Ventricular Non-compaction with Congenital Heart Disease on Perioperative Outcomes.

Ramachandran P, Woo JG, Ryan TD, Bryant R, Heydarian HC, Jefferies JL, Towbin JA, Lorts A.

Pediatr Cardiol. 2016 Oct;37(7):1307-12. doi: 10.1007/s00246-016-1435-2.

 

  1. Decline of Systolic and Diastolic 2D Strain Rate During Follow-Up of HLHS Patients After Fontan Palliation.

Michel M, Logoteta J, Entenmann A, Hansen JH, Voges I, Kramer HH, Petko C.

Pediatr Cardiol. 2016 Oct;37(7):1250-7. doi: 10.1007/s00246-016-1424-5.

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