11/ 2014 Fetal Cardiology

1. The effect of pregestational diabetes on fetal heart function.

Pauliks LB.

Expert Rev Cardiovasc Ther. 2014 Nov 28:1-8. [Epub ahead of print]

PMID: 25431859 [PubMed – as supplied by publisher]

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2. Pregestational Diabetes Induces Fetal Coronary Artery Malformation via Reactive Oxygen Species Signaling.

Moazzen H, Lu X, Liu M, Feng Q.

Diabetes. 2014 Nov 24. pii: DB_140190. [Epub ahead of print]

PMID: 25422104 [PubMed – as supplied by publisher]

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item 25416845

 

3. Growth and hemodynamics after early embryonic aortic arch occlusion.

Lindsey SE, Menon PG, Kowalski WJ, Shekhar A, Yalcin HC, Nishimura N, Schaffer CB, Butcher JT, Pekkan K.

Biomech Model Mechanobiol. 2014 Nov 23. [Epub ahead of print]

PMID: 25416845 [PubMed – as supplied by publisher]

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4. Prenatal Diagnosis of a Persistent Fifth Aortic Arch, Pulmonary-to-Systemic type: An Unusual Association with Evolving Aortic Coarctation.

Bhatla P, Chakravarti S, Axel L, Ludomirsky A, Revah G.

Echocardiography. 2014 Nov 21. doi: 10.1111/echo.12850. [Epub ahead of print]

PMID: 25418608 [PubMed – as supplied by publisher]

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5. Ratio between fms-like Tyrosine Kinase 1 and Placental Growth Factor in Children with Congenital Heart Disease.

Sugimoto M, Oka H, Kajihama A, Nakau K, Kuwata S, Kurishima C, Azuma H.

Pediatr Cardiol. 2014 Nov 12. [Epub ahead of print]

PMID: 25388629 [PubMed – as supplied by publisher]

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6. A Novel NKX2.6 Mutation Associated with Congenital Ventricular Septal Defect.

Wang J, Mao JH, Ding KK, Xu WJ, Liu XY, Qiu XB, Li RG, Qu XK, Xu YJ, Huang RT, Xue S, Yang YQ.

Pediatr Cardiol. 2014 Nov 8. [Epub ahead of print]

PMID: 25380965 [PubMed – as supplied by publisher]

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7. Severe neonatal presentation of Kleefstra syndrome in a patient with hypoplastic left heart syndrome and 9q34.3 microdeletion.

Campbell CL, Collins RT 2nd, Zarate YA.

Birth Defects Res A Clin Mol Teratol. 2014 Nov 7. doi: 10.1002/bdra.23324. [Epub ahead of print]

PMID: 25380126 [PubMed – as supplied by publisher]

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8. Screening of copy number variants in the 22q11.2 region of congenital heart disease patients from the São Miguel Island, Azores, revealed the second patient with a triplication.

Pires R, Pires LM, Vaz SO, Maciel P, Anjos R, Moniz R, Branco CC, Cabral R, Carreira IM, Mota-Vieira L.

BMC Genet. 2014 Nov 7;15(1):115. [Epub ahead of print]

PMID: 25376777 [PubMed – as supplied by publisher] Free PMC Article

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9. A mutation in the Kozak sequence of GATA4 hampers translation in a family with atrial septal defects.

Mohan RA, van Engelen K, Stefanovic S, Barnett P, Ilgun A, Baars MJ, Bouma BJ, Mulder BJ, Christoffels VM, Postma AV.

Am J Med Genet A. 2014 Nov;164(11):2732-8. doi: 10.1002/ajmg.a.36703. Epub 2014 Aug 5.

PMID: 25099673 [PubMed – in process]

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10. RASopathy-Associated CBL Germline Mutations Cause Aberrant Ubiquitylation and Trafficking of EGFR.

Brand K, Kentsch H, Glashoff C, Rosenberger G.

Hum Mutat. 2014 Nov;35(11):1372-81. doi: 10.1002/humu.22682.

PMID: 25178484 [PubMed – in process]

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11. Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress.

Gross CM, Aggarwal S, Kumar S, Tian J, Kasa A, Bogatcheva N, Datar SA, Verin AD, Fineman JR, Black SM.

J Cell Physiol. 2014 Nov;229(11):1802-16. doi: 10.1002/jcp.24633.

PMID: 24677020 [PubMed – indexed for MEDLINE]

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12. First-trimester fetal cardiac examination using spatiotemporal image correlation, tomographic ultrasound and color Doppler imaging for the diagnosis of complex congenital heart disease in high-risk patients.

Turan S, Turan OM, Desai A, Harman CR, Baschat AA.

Ultrasound Obstet Gynecol. 2014 Nov;44(5):562-7. doi: 10.1002/uog.13341. Epub 2014 Oct 15.

PMID: 24585667 [PubMed – in process]

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13. Differential and linear insertion of atrioventricular valves: a useful tool?

Adriaanse BM, Bartelings MM, van Vugt JM, Chaoui R, Gittenberger-de Groot AC, Haak MC.

Ultrasound Obstet Gynecol. 2014 Nov;44(5):568-74. doi: 10.1002/uog.13326.

PMID: 24515626 [PubMed – in process]

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Oxygen Supply to the Fetal Cerebral Circulation in Hypoplastic Left Heart Syndrome: A Simulation Study Based on the Theoretical Models of Fetal Circulation.

Oxygen Supply to the Fetal Cerebral Circulation in Hypoplastic Left Heart Syndrome: A Simulation Study Based on the Theoretical Models of Fetal Circulation.

Sakazaki S, Masutani S, Sugimoto M, Tamura M, Kuwata S, Kurishima C, Saiki H, Iwamoto Y, Ishido H, Senzaki H.

Pediatr Cardiol. 2014 Nov 15. [Epub ahead of print]

PMID: 25398259 [PubMed – as supplied by publisher]

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 Comment from Dr. Shaji Menon, section editor of fetal cardiology journal watch:  Comment from: Children born with congenital heart disease (CHD) are at high risk for development of neurodevelopmental abnormalities. Postnatal risk factors for development of neurodevelopmental abnormalities include a multitude of CHD and its surgery associated risk factors like chronic severe hypoxemia, failure to thrive, arrhythmias with cardiac arrest or hypotension. However, more recently neuroimaging studies have identified brain abnormalities in fetuses and newborns with CHD at birth before surgical intervention. These findings points to an abnormal intrauterine brain development in fetuses with CHD.  In this study investigators performed complex mathematical simulation studies on newborns with CHD to evaluate the cerebral circulation during the fetal period in three different CHDs 1) tricuspid atresia (TA), 2) transposition of the great arteries (TGA) and 3) hypoplastic left heart syndrome (HLHS). The figure below from the article shows the mathematical model of normal fetal circulation compared to those with HLHS, TA and TGA. Based on the simulation results, investigators concluded that the oxygen saturation of cerebral blood flow in newborns with both HLHS and TA was significantly lower (49.5%) compared to fetuses with normal circulation (75.7 %). The oxygen saturation was the lowest in TGA at 43.2 % (figure 2). The results of this study provides a developmental basis for high incidence of neurodevelopment abnormalities seen in patients with these congenital heart disease.

fetal 2.1 fetal 2.2

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Postmortem microcomputed tomography (micro-CT) of small fetuses and hearts

Postmortem microcomputed tomography (micro-CT) of small fetuses and hearts.

Lombardi CM, Zambelli V, Botta G, Moltrasio F, Cattoretti G, Lucchini V, Fesslova V, Cuttin MS.

Ultrasound Obstet Gynecol. 2014 Nov;44(5):600-9. doi: 10.1002/uog.13330. Epub 2014 Oct 13.

PMID: 24585450 [PubMed – in process]

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Comment from Dr. Ginnie Abarbanell, section editor of fetal cardiology journal watch:  This is a pilot study to assess the feasibility of microcomputed tomography (micro-CT) in small fetuses and fetal organs post-mortem to reduce the need for autopsy.  Micro-MRI and micro-CT have been designed for imaging of small research animals.  Results were very encouraging that micro-CT maybe a reasonable substitute to autopsy in small fetuses and/or fetal organs.

fetal 1.1

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