Fetal Cardiology Featured Articles of September 2017

 

Fetal Cardiology Reviews of September 2017 Manuscripts

 

Chronic antepartum maternal hyperoxygenation in a case of severe fetal Ebstein’s anomaly with circular shunt physiology.

Arunamata A, Axelrod DM, Bianco K, Balasubramanian S, Quirin A, Tacy TA.

Ann Pediatr Cardiol. 2017 Sep-Dec;10(3):284-287. doi: 10.4103/apc.APC_20_17.

PMID: 28928616 Free PMC Article

Similar articles

Select item 28928614

 

Take Home Points:

  • Fetal diagnosis of Ebstein’s anomaly of the tricuspid valve is associated with high perinatal mortality.
  • Significant pulmonary regurgitation in fetal Ebstein’s anomaly may be associated with circular shunt and reduced cardiac output.
  • Early constriction of the ductus arteriosus using chronic antepartum maternal oxygen therapy may be a novel perinatal management strategy to reduce systemic steal resulting from pulmonary valve regurgitation associated circular shunt physiology.

 

Shaji Menon Portrait 12.15.14Commentary from Dr Shaji Menon (Salt Lake City), section editor of Pediatric Cardiology Journal Watch:  Fetal diagnosis of Ebstein’s anomaly of the tricuspid valve is associated with high perinatal mortality.  In contemporary recent multicenter series, the perinatal mortality is close to 45%.  This case reports demonstrates the possibility of using maternal oxygen therapy in a high-risk fetus with severe Ebstein’s anomaly of tricuspid valve and circular shunt for premature ductal constriction (figure 1). The mother was admitted to the hospital at 33 weeks of gestation for maternal oxygen therapy with 6 L/min through nonrebreather facemask for 4 h, 3 times daily with serial fetal echocardiograms until delivery.  Following maternal oxygen therapy, there was restriction in blood flow across the ductus arteriosus (figure 2).  The fetus was delivered at 36 weeks of gestation.

Sept Fetal 1

Sept Fetal 2

 

Fetal Cardiology and genetics Sept 2017

 

  1. Echogenic intracardiac foci and fetal cardiac anomalies: A review of cases from a tertiary care center in China.

Guo Y, He Y, Gu X, Zhang Y, Sun L, Liu X, Zhao Y, Han J.

J Clin Ultrasound. 2017 Sep 29. doi: 10.1002/jcu.22533. [Epub ahead of print]

PMID: 28961313

Similar articles

Select item 28954835

 

  1. Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis.

Kennedy L, Kaltenbrun E, Greco TM, Temple B, Herring LE, Cristea IM, Conlon FL.

PLoS Genet. 2017 Sep 25;13(9):e1007011. doi: 10.1371/journal.pgen.1007011. [Epub ahead of print]

PMID: 28945738 Free Article

Similar articles

Select item 28944616

 

  1. The 22q11.2 deletion syndrome: Cancer predisposition, platelet abnormalities and cytopenias.

Lambert MP, Arulselvan A, Schott A, Markham SJ, Crowley TB, Zackai EH, McDonald-McGinn DM.

Am J Med Genet A. 2017 Sep 22. doi: 10.1002/ajmg.a.38474. [Epub ahead of print] Review.

PMID: 28940864

Similar articles

Select item 28947226

 

  1. A66G and C524T polymorphisms of methionine synthase reductase gene are linked to the development of acyanotic congenital heart diseases in Egyptian children.

Hassan FM, Khattab AA, Abo El Fotoh WMM, Zidan RS.

Gene. 2017 Sep 20;629:59-63. doi: 10.1016/j.gene.2017.07.081. Epub 2017 Aug 2.

PMID: 28778621

Similar articles

Select item 28940686

 

  1. Heterozygous deletion of AKT1 rescues cardiac contractility, but not hypertrophy, in a mouse model of Noonan Syndrome with Multiple Lentigines.

Roy R, Krenz M.

J Mol Cell Cardiol. 2017 Sep 11;112:83-90. doi: 10.1016/j.yjmcc.2017.09.003. [Epub ahead of print]

PMID: 28911943

Similar articles

Select item 28882282

 

  1. Human hepatic organoids for the analysis of human genetic diseases.

Guan Y, Xu D, Garfin PM, Ehmer U, Hurwitz M, Enns G, Michie S, Wu M, Zheng M, Nishimura T, Sage J, Peltz G.

JCI Insight. 2017 Sep 7;2(17). pii: 94954. doi: 10.1172/jci.insight.94954. [Epub ahead of print]

PMID: 28878125 Free Article

Similar articles

Select item 28878122

 

  1. Wnt11 regulates cardiac chamber development and disease during perinatal maturation.

Touma M, Kang X, Gao F, Zhao Y, Cass AA, Biniwale R, Xiao X, Eghbali M, Coppola G, Reemtsen B, Wang Y.

JCI Insight. 2017 Sep 7;2(17). pii: 94904. doi: 10.1172/jci.insight.94904. [Epub ahead of print]

PMID: 28878122 Free Article

Similar articles

Select item 28880023

 

  1. A prenatal diagnosis of mosaic trisomy 5 reveals a postnatal complete uniparental disomy of chromosome 5 with multiple congenital anomalies.

Reittinger AM, Helm BM, Boles DJ, Gadi IK, Schrier Vergano SA.

Am J Med Genet A. 2017 Sep;173(9):2528-2533. doi: 10.1002/ajmg.a.38344. Epub 2017 Jun 27.

PMID: 28653809

Similar articles

Select item 28636109

 

  1. Xq26.1-26.3 duplication including MOSPD1 and GPC3 identified in boy with short stature and double outlet right ventricle.

Hirota Y, Minami T, Sato T, Yokomizo A, Matsumoto A, Goto M, Jinbo E, Yamamgata T.

Am J Med Genet A. 2017 Sep;173(9):2446-2450. doi: 10.1002/ajmg.a.38297. Epub 2017 Jun 21.

PMID: 28636109

Similar articles

Select item 28626076

 

  1. Chronic antepartum maternal hyperoxygenation in a case of severe fetal Ebstein’s anomaly with circular shunt physiology.

Arunamata A, Axelrod DM, Bianco K, Balasubramanian S, Quirin A, Tacy TA.

Ann Pediatr Cardiol. 2017 Sep-Dec;10(3):284-287. doi: 10.4103/apc.APC_20_17.

PMID: 28928616 Free PMC Article

Similar articles

Select item 28928614

 

  1. Hypomethylation and decreased expression of BRG1 in the myocardium of patients with congenital heart disease.

Qian Y, Xiao D, Guo X, Chen H, Hao L, Ma X, Huang G, Ma D, Wang H.

Birth Defects Res. 2017 Sep 1;109(15):1183-1195. doi: 10.1002/bdr2.1053. Epub 2017 Jun 24.

PMID: 28646505

Similar articles

Select item 28395882

 

  1. Congenital heart disease and genetic syndromes: new insights into molecular mechanisms.

Calcagni G, Unolt M, Digilio MC, Baban A, Versacci P, Tartaglia M, Baldini A, Marino B.

Expert Rev Mol Diagn. 2017 Sep;17(9):861-870. doi: 10.1080/14737159.2017.1360766. Epub 2017 Aug 3.

PMID: 28745539

Similar articles

 

  1. A case of prenatally detected left isomerism and hemiazygos continuation of inferior vena cava.

Moradi B, Moosavi NS, Kazemi MA, Tahmasebpour AR, Fattahi Masrour F.

J Clin Ultrasound. 2017 Sep;45(7):430-433. doi: 10.1002/jcu.22464. Epub 2017 Mar 3.

PMID: 28256002

Similar articles

Select item 26908585

 

  1. Relationship of the MTHFD1 (rs2236225), eNOS (rs1799983), CBS (rs2850144) and ACE (rs4343) gene polymorphisms in a population of Iranian pediatric patients with congenital heart defects.

Khatami M, Ratki FM, Tajfar S, Akrami F.

Kaohsiung J Med Sci. 2017 Sep;33(9):442-448. doi: 10.1016/j.kjms.2017.05.016. Epub 2017 Jul 13.

PMID: 28865601 Free Article

Similar articles

Select item 28412020

 

  1. Endothelial to mesenchymal transition in the cardiovascular system.

Gong H, Lyu X, Wang Q, Hu M, Zhang X.

Life Sci. 2017 Sep 1;184:95-102. doi: 10.1016/j.lfs.2017.07.014. Epub 2017 Jul 14. Review.

PMID: 28716564

Similar articles

Select item 28698113

 

  1. Prenatal ultrasonic diagnosis of absent pulmonary valve syndrome: A case report.

Zhang WJ, Zhang ZL, Chang JJ, Song XY.

Medicine (Baltimore). 2017 Sep;96(35):e7747. doi: 10.1097/MD.0000000000007747.

PMID: 28858090 Free PMC Article

Similar articles

Select item 28713984

 

  1. Downregulation of microRNA‑199a‑5p protects cardiomyocytes in cyanotic congenital heart disease by attenuating endoplasmic reticulum stress.

Zhou Y, Jia WK, Jian Z, Zhao L, Liu CC, Wang Y, Xiao YB.

Mol Med Rep. 2017 Sep;16(3):2992-3000. doi: 10.3892/mmr.2017.6934. Epub 2017 Jul 6.

PMID: 28713984

Similar articles

Select item 28677747

 

  1. MESP1 loss‑of‑function mutation contributes to double outlet right ventricle.

Zhang M, Li FX, Liu XY, Huang RT, Xue S, Yang XX, Li YJ, Liu H, Shi HY, Pan X, Qiu XB, Yang YQ.

Mol Med Rep. 2017 Sep;16(3):2747-2754. doi: 10.3892/mmr.2017.6875. Epub 2017 Jun 29.

PMID: 28677747

Similar articles

Select item 28864942

 

  1. A Dutch MYH7 founder mutation, p.(Asn1918Lys), is associated with early onset cardiomyopathy and congenital heart defects.

van der Linde IHM, Hiemstra YL, Bökenkamp R, van Mil AM, Breuning MH, Ruivenkamp C, Ten Broeke SW, Veldkamp RF, van Waning JI, van Slegtenhorst MA, van Spaendonck-Zwarts KY, Lekanne Deprez RH, Herkert JC, Boven L, van der Zwaag PA, Jongbloed JDH, Bootsma M, Barge-Schaapveld DQCM.

Neth Heart J. 2017 Sep 1. doi: 10.1007/s12471-017-1037-5. [Epub ahead of print]

PMID: 28864942

Similar articles

Select item 28687308

 

  1. Incidental Findings on Routine Targeted Neonatal Echocardiography Performed in Preterm Neonates Younger Than 29 Weeks’ Gestation.

Smith A, Breatnach CR, James AT, Franklin O, El-Khuffash A.

J Ultrasound Med. 2017 Sep 25. doi: 10.1002/jum.14422. [Epub ahead of print]

PMID: 28945279

Similar articles

Select item 28948390

 

  1. Prenatal Diagnosis of Total and Partial Anomalous Pulmonary Venous Connection. Multicentre Cohort Study and Meta-analysis.

Paladini D, Pistorio A, Wu LH, Meccariello G, Lei T, Tuo G, Donarini G, Marasini M, Xie HN.

Ultrasound Obstet Gynecol. 2017 Sep 19. doi: 10.1002/uog.18907. [Epub ahead of print] Review.

PMID: 28926132

Similar articles

Select item 28935350

 

  1. Prenatal diagnosis of isolated total anomalous systemic venous connection to the left atrium.

Miltner B, Poncelet AJ, Barrea C.

Cardiol Young. 2017 Sep;27(7):1394-1397. doi: 10.1017/S1047951117000300. Epub 2017 Jun 8.

PMID: 28592338

Similar articles

Select item 28506331

 

  1. Prenatal diagnosis of aortopulmonary window associated with aberrant subclavian artery.

Louis-Jacques AF, Običan SG, Nguyen T, Odibo A.

Cardiol Young. 2017 Sep;27(7):1441-1443. doi: 10.1017/S104795111700035X. Epub 2017 Mar 16.

PMID: 28300009

Similar articles

Select item 28183375

 

  1. Microarray analysis reveals key genes and pathways in Tetralogy of Fallot.

He YE, Qiu HX, Jiang JB, Wu RZ, Xiang RL, Zhang YH.

Mol Med Rep. 2017 Sep;16(3):2707-2713. doi: 10.3892/mmr.2017.6933. Epub 2017 Jul 6.

PMID: 28713939

Similar articles

Select item 28524415

 

  1. Prenatal management of fetal intrapericardial teratoma: a systematic review.

Nassr AA, Shazly SA, Morris SA, Ayres N, Espinoza J, Erfani H, Olutoye OA, Sexson SK, Olutoye OO, Fraser CD Jr, Belfort MA, Shamshirsaz AA.

Prenat Diagn. 2017 Sep;37(9):849-863. doi: 10.1002/pd.5113. Epub 2017 Aug 7. Review.

PMID: 28695637

Similar articles

Select item 28820653

 

  1. Fetal giant cardiac tumor.

Mendes IC, Araújo AR, Anjos R, Teixeira A.

Rev Port Cardiol. 2017 Sep;36(9):673-674. doi: 10.1016/j.repc.2016.09.022. Epub 2017 Sep 4. English, Portuguese. No abstract available.

PMID: 28882656

Similar articles

Select item 28902645

 

 

(No Ratings Yet)
Loading...Loading...

Fetal Cardiology Featured Articles of July 2017

Fetal Cardiology Reviews of July 2017 Manuscripts

 

Persistently elevated nuchal translucency and the fetal heart.

Vigneswaran TV, Homfray T, Allan LD, Simpson JM, Zidere V.

J Matern Fetal Neonatal Med. 2017 Jul 4:1-5. doi: 10.1080/14767058.2017.1342804. [Epub ahead of print]

PMID: 28614966

 

Take Home Points:

 

  • Fetuses with persistently elevated nuchal edema (> 6 mm) had significantly increased incidence of congenital heart disease and Noonan syndrome at birth
  • The most common abnormalities of pulmonary stenosis and hypertrophic cardiomyopathy were not always apparent at the 20 week scan, so late gestation fetal echo re-evaluation should be done in this cohort

Hershenson, JaredCommentary from Dr. Jared Hershenson (Greater Washington DC), section editor of Fetal Cardiology Journal Watch: Nuchal edema in the 2nd trimester is defined as a nuchal fold thickness > 6 mm. While most fetal cardiologists see many fetal patients with an increased NT, nuchal edema may represent a much higher risk cohort. All patients with an NT > 95th percentile in the first trimester had fetal echocardiograms in the 2nd trimester. If NT or NE was present during the 2nd trimester, a further fetal echocardiogram was performed in the 3rd trimester even if the first fetal echo was normal. This study looked at 15 cases with NE in the 2nd trimester. 10/15 had extracardiac findings in the 2nd trimester, most commonly pleural effusions. By the 3rd trimester, 100% had polyhydramnios. Cardiac findings during the 2nd trimester fetal echo included pulmonary stenosis, LVOT obstruction and HCM, with more patients developing these in the 3rd trimester and postnatally (see table 1).  11/15 patients were genetically confirmed to have Noonan syndrome. This was a very small case-series, but it does highlight the need for late gestation fetal echo, postnatal echo and genetic testing in those with nuchal edema, as many findings were not present on the first 2nd trimester fetal echo.

July 2017 fetal 1

 

Fetal cardiology July 2017

 

  1. Nuclear/cytoplasmic transport defects in BBS6 underlie congenital heart disease through perturbation of a chromatin remodeling protein.

Scott CA, Marsden AN, Rebagliati MR, Zhang Q, Chamling X, Searby CC, Baye LM, Sheffield VC, Slusarski DC.

PLoS Genet. 2017 Jul 28;13(7):e1006936. doi: 10.1371/journal.pgen.1006936. [Epub ahead of print]

PMID: 28753627 Free Article

Similar articles

Select item 28751538

 

  1. Prenatal Maternal Hyperoxygenation Testing and Implications for Critical Care Delivery Planning among Fetuses with Congenital Heart Disease: Early Experience.

Schidlow DN, Donofrio MT.

Am J Perinatol. 2017 Jul 26. doi: 10.1055/s-0037-1603991. [Epub ahead of print] No abstract available.

PMID: 28746973

Similar articles

Select item 28744980

 

  1. A TBX5 3’UTR variant increases the risk of congenital heart disease in the Han Chinese population.

Wang F, Liu D, Zhang RR, Yu LW, Zhao JY, Yang XY, Jiang SS, Ma D, Qiao B, Zhang F, Jin L, Gui YH, Wang HY.

Cell Discov. 2017 Jul 25;3:17026. doi: 10.1038/celldisc.2017.26. eCollection 2017.

PMID: 28761722 Free PMC Article

Similar articles

Select item 28741863

 

  1. Functional study of DAND5 variant in patients with Congenital Heart Disease and laterality defects.

Cristo F, Inácio JM, de Almeida S, Mendes P, Martins DS, Maio J, Anjos R, Belo JA.

BMC Med Genet. 2017 Jul 24;18(1):77. doi: 10.1186/s12881-017-0444-1.

PMID: 28738792 Free PMC Article

Similar articles

Select item 28737730

 

  1. A missense mutation in <i>TCN2</i> is associated with decreased risk for congenital heart defects and may increase cellular uptake of vitamin B12 via Megalin.

Li P, Huang L, Zheng Y, Pan X, Peng R, Jiang Y, Finnell RH, Li H, Qiao B, Wang HY.

Oncotarget. 2017 Jul 19. doi: 10.18632/oncotarget.19377. [Epub ahead of print]

PMID: 28746916 Free Article

Similar articles

Select item 28725922

 

  1. In Utero Evidence of Impaired Somatic Growth in Hypoplastic Left Heart Syndrome.

Triebwasser JE, Treadwell MC.

Pediatr Cardiol. 2017 Jul 8. doi: 10.1007/s00246-017-1676-8. [Epub ahead of print]

PMID: 28689327

Similar articles

Select item 28687876

 

  1. Early Evaluation of the Fetal Heart.

Hernandez-Andrade E, Patwardhan M, Cruz-Lemini M, Luewan S.

Fetal Diagn Ther. 2017 Jul 5. doi: 10.1159/000477564. [Epub ahead of print]

PMID: 28675906

Similar articles

Select item 28681101

 

  1. Persistently elevated nuchal translucency and the fetal heart.

Vigneswaran TV, Homfray T, Allan LD, Simpson JM, Zidere V.

J Matern Fetal Neonatal Med. 2017 Jul 4:1-5. doi: 10.1080/14767058.2017.1342804. [Epub ahead of print]

PMID: 28614966

Similar articles

Select item 28402072

 

  1. Congenital Lung Agenesis: Incidence and Outcome in the North of England.

Thomas M, Robertson N, Miller N, Rankin J, McKean M, Brodlie M.

Birth Defects Res. 2017 Jul 3;109(11):857-859. doi: 10.1002/bdr2.1011. Epub 2017 Apr 12.

PMID: 28402072

Similar articles

Select item 28675696

 

  1. The prognostic factors of hydrops fetalis with pleural effusion.

Nakayama A, Oshiro M, Yamada Y, Hattori T, Wakano Y, Hayashi S, Kokubo M, Takemoto K, Honda S, Ieda K, Yamamoto H, Kouwaki M, Yokoi K, Shinohara O, Kato T, Miyata M, Tanaka T, Hayakawa M.

Pediatr Int. 2017 Jul 3. doi: 10.1111/ped.13357. [Epub ahead of print]

PMID: 28672054

Similar articles

Select item 28670826

 

  1. Microarrays in prenatal diagnosis.

Oneda B, Rauch A.

Best Pract Res Clin Obstet Gynaecol. 2017 Jul;42:53-63. doi: 10.1016/j.bpobgyn.2017.01.003. Epub 2017 Jan 23. Review.

PMID: 28215395

Similar articles

Select item 28555538

 

  1. Fetal Cardiac US: Techniques and Normal Anatomy Correlated with Adult CT and MR Imaging.

Patel N, Narasimhan E, Kennedy A.

Radiographics. 2017 Jul-Aug;37(4):1290-1303. doi: 10.1148/rg.2017160126. Epub 2017 Jun 2.

PMID: 28574808

Similar articles

Select item 28601176

 

  1. Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development.

Kodo K, Shibata S, Miyagawa-Tomita S, Ong SG, Takahashi H, Kume T, Okano H, Matsuoka R, Yamagishi H.

Sci Rep. 2017 Jul 28;7(1):6771. doi: 10.1038/s41598-017-06964-9.

PMID: 28754980 Free PMC Article

Similar articles

Select item 28755020

 

  1. Dysfunction of the foetal arterial duct results in a wide spectrum of cardiovascular pathology.

Gewillig M, Brown SC, Roggen M, Eyskens B, Heying R, Givron P, Cools B, de Catte L.

Acta Cardiol. 2017 Jul 26:1-11. doi: 10.1080/00015385.2017.1314876. [Epub ahead of print]

PMID: 28745124

Similar articles

Select item 28761023

 

  1. Circulating mRNA in Maternal Plasma at the Second Trimester of Pregnancy: A Possible Screening Tool for Cardiac Conotruncal and Left Ventricular Outflow Tract Abnormalities.

Contro E, Stefani L, Berto S, Lapucci C, Arcelli D, Prandstraller D, Perolo A, Rizzo N, Farina A.

Mol Diagn Ther. 2017 Jul 25. doi: 10.1007/s40291-017-0295-7. [Epub ahead of print]

PMID: 28744745

Similar articles

Select item 28514771

 

  1. Preserved heart function after left ventricular pressure overload in adult mice subjected to neonatal cardiac hypoplasia.

Heinecke K, Heuser A, Blaschke F, Jux C, Thierfelder L, Drenckhahn JD.

J Dev Orig Health Dis. 2017 Jul 24:1-13. doi: 10.1017/S2040174417000514. [Epub ahead of print]

PMID: 28737122

Similar articles

Select item 28707556

 

  1. Informed consent and informed decision in maternal fetal neonatal medicine: do they go hand in hand?

Matsubara S, Matsubara D.

J Matern Fetal Neonatal Med. 2017 Jul 24:1-2. doi: 10.1080/14767058.2017.1355904. [Epub ahead of print] No abstract available.

PMID: 28707556

Similar articles

Select item 28728660

 

  1. Fetal Right Ventricular Prominence: Associated Postnatal Abnormalities and Coarctation Clinical Prediction Tool.

Power A, Nettel-Aguirre A, Fruitman D.

Pediatr Cardiol. 2017 Jul 24. doi: 10.1007/s00246-017-1686-6. [Epub ahead of print]

PMID: 28741093

Similar articles

Select item 28738087

 

  1. Fetal programming as a predictor of adult health or disease: the need to reevaluate fetal heart function.

Miranda JO, Ramalho C, Henriques-Coelho T, Areias JC.

Heart Fail Rev. 2017 Jul 20. doi: 10.1007/s10741-017-9638-z. [Epub ahead of print] Review.

PMID: 28730459

Similar articles

Select item 28724804

 

  1. Response to Letter Regarding Article, “Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis”.

Familiari A, Morlando M, Sonesson SE, Rizzo G, Acharya G, Manzoli L, D’Antonio F.

Circulation. 2017 Jul 18;136(3):338-339. doi: 10.1161/CIRCULATIONAHA.117.029014. No abstract available.

PMID: 28716837

Similar articles

Select item 28716836

 

  1. Letter by Ceylan Regarding Article, “Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis”.

Ceylan Ö.

Circulation. 2017 Jul 18;136(3):336-337. doi: 10.1161/CIRCULATIONAHA.117.028081. No abstract available.

PMID: 28716836

Similar articles

Select item 28719142

 

  1. Automated analysis of fetal cardiac function using color tissue Doppler imaging.

Herling L, Johnson J, Ferm-Widlund K, Bergholm F, Lindgren P, Sonesson SE, Acharya G, Westgren M.

Ultrasound Obstet Gynecol. 2017 Jul 17. doi: 10.1002/uog.18812. [Epub ahead of print]

PMID: 28715153

Similar articles

Select item 28713076

 

  1. Prenatal management of fetal intrapericardial teratoma: a systematic review.

Nassr AA, Shazly SA, Morris SA, Ayres N, Espinoza J, Erfani H, Olutoye OA, Sexson SK, Olutoye OO, Fraser CD Jr, Belfort MA, Shamshirsaz AA.

Prenat Diagn. 2017 Jul 10. doi: 10.1002/pd.5113. [Epub ahead of print] Review.

PMID: 28695637

Similar articles

Select item 28735782

 

  1. In Utero Evidence of Impaired Somatic Growth in Hypoplastic Left Heart Syndrome.

Triebwasser JE, Treadwell MC.

Pediatr Cardiol. 2017 Jul 8. doi: 10.1007/s00246-017-1676-8. [Epub ahead of print]

PMID: 28689327

Similar articles

Select item 28708228

 

  1. Contrary microRNA Expression Pattern Between Fetal and Adult Cardiac Remodeling: Therapeutic Value for Heart Failure.

Yan H, Li Y, Wang C, Zhang Y, Liu C, Zhou K, Hua Y.

Cardiovasc Toxicol. 2017 Jul;17(3):267-276. doi: 10.1007/s12012-016-9381-z.

PMID: 27509882

Similar articles

Select item 28295963

 

  1. CITED2 Mutations in Conserved Regions Contribute to Conotruncal Heart Defects in Chinese Children.

Li B, Pu T, Liu Y, Xu Y, Xu R.

DNA Cell Biol. 2017 Jul;36(7):589-595. doi: 10.1089/dna.2017.3701. Epub 2017 Apr 24.

PMID: 28436679

Similar articles

Select item 28497556

 

  1. Evolution of ventricular outpouching through the fetal and postnatal periods: Unabating dilemma of serial observation or surgical correction.

Dipak NK, Venkatesh S, Prabhu S, Rao S.

J Saudi Heart Assoc. 2017 Jul;29(3):203-210. doi: 10.1016/j.jsha.2016.10.004. Epub 2016 Oct 20. Review.

PMID: 28652674 Free PMC Article

Similar articles

Select item 28434620

 

  1. Prenatal exposure to serotonin reuptake inhibitors and congenital heart anomalies: an exploratory pharmacogenetics study.

Daud ANA, Bergman JEH, Kerstjens-Frederikse WS, van der Vlies P, Hak E, Berger RMF, Groen H, Wilffert B.

Pharmacogenomics. 2017 Jul;18(10):987-1001. doi: 10.2217/pgs-2017-0036. Epub 2017 Jun 22.

PMID: 28639488

Similar articles

(No Ratings Yet)
Loading...Loading...

Fetal Cardiology Featured Articles of June 2017

Fetal Cardiology June 2017

Common Findings in Late-Gestation Fetal Echocardiography.

Tague L, Donofrio MT, Fulgium A, McCarter R, Limperopoulos C, Schidlow DN.

J Ultrasound Med. 2017 Jun 19. doi: 10.1002/jum.14283. [Epub ahead of print]

PMID: 28627028

 

Take home points:

  • There are common findings seen in late gestation fetal echocardiograms that are likely benign
  • This knowledge can help with counseling and likely lead to more cost-effective care when avoiding unnecessary follow up.

Hershenson, JaredCommentary from Dr. Jared Hershenson (Greater Washington DC), section editor of Fetal Cardiology Journal Watch: As most fetal cardiologists know, late gestation fetal echocardiograms are becoming more commonly ordered. This study sought to describe common cardiac findings during late gestation. 40 fetuses with structurally normal hearts as identified by midgestation fetal echocardiography had images taken before and after 34 weeks gestation.  Additionally, all had normal growth, normal cerebral blood flow patterns, and no evidence of placental insufficiency. A standard fetal protocol was used. Table 1 lists the findings seen more frequently in late gestation, including right atrial enlargement, ductus narrowing, trivial or mild tricuspid regurgitation and aneurysmal atrial septum. Prominent diastolic ductal and aortic isthmus flow (antegrade diastolic flow without aliasing by color Doppler) were noted as well. While no post-natal echocardiograms were performed, all had cardiology evaluation and none had concerning symptoms or exam findings. The article does not compare Doppler velocities across any of the valves. The authors conclude that the above findings are likely normal at this gestational age, and should not warrant post-natal assessment.

June fetal v1 June fetal v2

 

 

 

 

 

Left Ventricular Rotational and Twist Mechanics in the Human Fetal Heart.

Li L, Craft M, Hsu HH, Zhang M, Klas B, Danford DA, Kutty S.

J Am Soc Echocardiogr. 2017 Jun 6. pii: S0894-7317(17)30278-X. doi: 10.1016/j.echo.2017.04.006. [Epub ahead of print]

PMID: 28599825

Similar articles

Select item 28660071

 

Take Home Points

  • Assessment of fetal left ventricular (LV) rotational mechanics with two-dimensional speckle tracking echocardiography is feasible and reproducible.
  • Normal values of fetal LV rotational mechanics are provided.
  • LV apical rotation, twist, global circumferential strain, circumferential strain rate and torsion decreased with increasing gestational age and fetal weight.

 

Voges IngaComment from Dr. Inga Voges (London), section editor of Fetal Cardiology Journal Watch:

Left ventricular rotational mechanics in the fetus were investigated using two-dimensional speckle tracking echocardiography. Overall, 102 pregnant women were enrolled and 175 out of 240 echocardiographic studies were used for further analyses. Longitudinal data were available for 51 fetuses. Left ventricular basal and apical views as well as four-chamber views were acquired to measure  LV apical and basal rotation, twist (=net difference between apical and basal rotation) and torsion (=twist value normalized to LV end-diastolic length). Furthermore, LV global longitudinal and circumferential strain and strain rate were analyzed.

The authors nicely demonstrated that LV apical rotation, twist, global circumferential strain and circumferential strain rate declined with gestational age and estimated fetal weight (see figure). A strong negative non-linear correlation of LV torsion with gestational age and fetal weight was found (see figure). In addition, there was a moderate negative correlation of global circumferential strain and circumferential strain rate with torsion.

 

In summary, this is the first study providing normal values of LV rotational mechanics in the fetus. The presented data may help to improve our understanding of the fetal LV myocardial properties and pave the way for further research studies in this field.

June ped inga 3

 

Fetal Cardiology June 2017

 

  1. A prenatal diagnosis of mosaic trisomy 5 reveals a postnatal complete uniparental disomy of chromosome 5 with multiple congenital anomalies.

Reittinger AM, Helm BM, Boles DJ, Gadi IK, Schrier Vergano SA.

Am J Med Genet A. 2017 Jun 27. doi: 10.1002/ajmg.a.38344. [Epub ahead of print]

PMID: 28653809

Similar articles

Select item 28653806

 

  1. Assessment of large copy number variants in patients with apparently isolated congenital left-sided cardiac lesions reveals clinically relevant genomic events.

Hanchard NA, Umana LA, D’Alessandro L, Azamian M, Poopola M, Morris SA, Fernbach S, Lalani SR, Towbin JA, Zender GA, Fitzgerald-Butt S, Garg V, Bowman J, Zapata G, Hernandez P, Arrington CB, Furthner D, Prakash SK, Bowles NE, McBride KL, Belmont JW.

Am J Med Genet A. 2017 Jun 27. doi: 10.1002/ajmg.a.38309. [Epub ahead of print]

PMID: 28653806

Similar articles

Select item 28651679

 

  1. Hypomethylation and decreased expression of BRG1 in the myocardium of patients with congenital heart disease.

Qian Y, Xiao D, Guo X, Chen H, Hao L, Ma X, Huang G, Ma D, Wang H.

Birth Defects Res. 2017 Jun 24. doi: 10.1002/bdr2.1053. [Epub ahead of print]

PMID: 28646505

Similar articles

Select item 28647711

 

  1. Prenatal Diagnosis of Dextrocardia with Complex Congenital Heart Disease Using Fetal Intelligent Navigation Echocardiography (FINE) and a Literature Review.

Yeo L, Luewan S, Markush D, Gill N, Romero R.

Fetal Diagn Ther. 2017 Jun 23. doi: 10.1159/000468929. [Epub ahead of print]

PMID: 28641300

Similar articles

Select item 28646273

 

  1. Associations between toxic and essential trace elements in maternal blood and fetal congenital heart defects.

Ou Y, Bloom MS, Nie Z, Han F, Mai J, Chen J, Lin S, Liu X, Zhuang J.

Environ Int. 2017 Jun 20;106:127-134. doi: 10.1016/j.envint.2017.05.017. [Epub ahead of print]

PMID: 28645012

Similar articles

Select item 28645799

 

  1. Genotype-phenotype evaluation of MED13L defects in the light of a novel truncating and a recurrent missense mutation.

Asadollahi R, Zweier M, Gogoll L, Schiffmann R, Sticht H, Steindl K, Rauch A.

Eur J Med Genet. 2017 Jun 20. pii: S1769-7212(17)30152-0. doi: 10.1016/j.ejmg.2017.06.004. [Epub ahead of print]

PMID: 28645799

Similar articles

Select item 28619193

 

  1. Quantification of Cardiomyocyte Alignment from Three-Dimensional (3D) Confocal Microscopy of Engineered Tissue.

Kowalski WJ, Yuan F, Nakane T, Masumoto H, Dwenger M, Ye F, Tinney JP, Keller BB.

Microsc Microanal. 2017 Jun 19:1-17. doi: 10.1017/S1431927617000666. [Epub ahead of print]

PMID: 28625174

Similar articles

Select item 28631207

 

  1. Maternal autoimmune disorders and fetal defects.

Panaitescu AM, Nicolaides K.

J Matern Fetal Neonatal Med. 2017 Jun 18:1-9. doi: 10.1080/14767058.2017.1326904. [Epub ahead of print]

PMID: 28627279

Similar articles

Select item 28626076

 

  1. Persistently elevated nuchal translucency and the fetal heart.

Vigneswaran TV, Homfray T, Allan LD, Simpson JM, Zidere V.

J Matern Fetal Neonatal Med. 2017 Jun 14:1-13. doi: 10.1080/14767058.2017.1342804. [Epub ahead of print]

PMID: 28614966

Similar articles

Select item 28606952

 

  1. Recent advances in congenital heart disease genomics.

Wilsdon A, Sifrim A, Hitz MP, Hurles M, Brook JD.

F1000Res. 2017 Jun 12;6:869. doi: 10.12688/f1000research.10113.1. eCollection 2017. Review.

PMID: 28663792 Free PMC Article

 

Select item 28605249

 

  1. Peptidomic analysis of maternal serum to identify biomarker candidates for prenatal diagnosis of Tetralogy of Fallot.

Zhuang B, Hu Y, Fan X, Li M, Zhu J, Liu H, Cao L, Liang D, Zhang J, Yu Z, Han S.

J Cell Biochem. 2017 Jun 9. doi: 10.1002/jcb.26204. [Epub ahead of print]

PMID: 28598000

Similar articles

Select item 28604574

 

  1. Fetal and neonatal involvement in maternal rheumatologic disease.

Iijima S.

J Matern Fetal Neonatal Med. 2017 Jun 8:1-7. doi: 10.1080/14767058.2017.1334048. [Epub ahead of print]

PMID: 28532196

Similar articles

Select item 28598945

 

  1. Loss of function in ROBO1 is associated with tetralogy of Fallot and septal defects.

Kruszka P, Tanpaiboon P, Neas K, Crosby K, Berger SI, Martinez AF, Addissie YA, Pongprot Y, Sittiwangkul R, Silvilairat S, Makonkawkeyoon K, Yu L, Wynn J, Bennett JT, Mefford HC, Reynolds WT, Liu X, Mommersteeg MTM, Chung WK, Lo CW, Muenke M.

J Med Genet. 2017 Jun 7. pii: jmedgenet-2017-104611. doi: 10.1136/jmedgenet-2017-104611. [Epub ahead of print]

PMID: 28592524

Similar articles

Select item 28624383

 

  1. Fetal Cardiac US: Techniques and Normal Anatomy Correlated with Adult CT and MR Imaging.

Patel N, Narasimhan E, Kennedy A.

Radiographics. 2017 Jun 2:160126. doi: 10.1148/rg.2017160126. [Epub ahead of print]

PMID: 28574808

Similar articles

Select item 28328585

 

  1. Phenotyping cardiac and structural birth defects in fetal and newborn mice.

Liu X, Kim AJ, Reynolds W, Wu Y, Lo CW.

Birth Defects Res. 2017 Jun 1;109(10):778-790. doi: 10.1002/bdr2.1048. Epub 2017 May 22. Review.

PMID: 28544620

Similar articles

Select item 28457736

 

  1. Use of Clinical Exome Sequencing in Isolated Congenital Heart Disease.

Zahavich L, Bowdin S, Mital S.

Circ Cardiovasc Genet. 2017 Jun;10(3). pii: e001581. doi: 10.1161/CIRCGENETICS.116.001581. No abstract available.

PMID: 28473349

Similar articles

Select item 28468791

 

  1. Genetics of Congenital Heart Disease: Is the Glass Now Half-Full?

Leatherbury L, Berul CI.

Circ Cardiovasc Genet. 2017 Jun;10(3):e001746. doi: 10.1161/CIRCGENETICS.117.001746. No abstract available.

PMID: 28468791

Similar articles

Select item 28611116

 

  1. Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice.

Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T.

J Clin Invest. 2017 Jun 1;127(6):2235-2248. doi: 10.1172/JCI88725. Epub 2017 Apr 24.

PMID: 28436940 Free Article

Similar articles

Select item 28121016

 

  1. A Targeted, Next-Generation Genetic Sequencing Study on Tetralogy of Fallot, Combined With Cleft Lip and Palate.

Liu L, Bu H, Yang Y, Tan Z, Zhang F, Hu S, Zhao T.

J Craniofac Surg. 2017 Jun;28(4):e351-e355. doi: 10.1097/SCS.0000000000003598.

PMID: 28230599 Free PMC Article

Similar articles

Select item 28285866

 

  1. Role of HDLive in Imaging the Fetal Heart.

Lakshmy SR, Jain B, Rose N.

J Ultrasound Med. 2017 Jun;36(6):1267-1278. doi: 10.7863/ultra.16.05071. Epub 2017 Mar 11.

PMID: 28295440

Similar articles

Select item 28576477

 

  1. Developmental Changes in Aortic Mechanical Properties in Normal Fetuses and Fetuses with Cardiovascular Disease.

Taketazu M, Sugimoto M, Saiki H, Ishido H, Masutani S, Senzaki H.

Pediatr Neonatol. 2017 Jun;58(3):245-250. doi: 10.1016/j.pedneo.2016.05.004. Epub 2016 Sep 28.

PMID: 27816335 Free Article

Similar articles

Select item 27870384

 

  1. [Genetics of congenital heart diseases].

Bonnet D.

Presse Med. 2017 Jun;46(6 Pt 1):612-619. doi: 10.1016/j.lpm.2017.05.014. Epub 2017 Jun 2. French.

PMID: 28583745

Similar articles

Select item 28583744

 

  1. Successful Fetal Tele-Echo at a Small Regional Hospital.

Brown J, Holland B.

Telemed J E Health. 2017 Jun;23(6):485-492. doi: 10.1089/tmj.2016.0141. Epub 2016 Nov 18.

PMID: 27860542

Similar articles

Select item 27362312

 

  1. [NKX2.5 and TBX5 gene mutations in in vitro fertilization children with congenital heart disease].

Yang JH, Xu XY, Mi HY, Jiang Y, Ma XM, Li L.

Zhongguo Dang Dai Er Ke Za Zhi. 2017 Jun;19(6):652-657. Chinese.

PMID: 28606231 Free Article

Similar articles

 

  1. Prenatal exposure to serotonin reuptake inhibitors and congenital heart anomalies: an exploratory pharmacogenetics study.

Daud ANA, Bergman JEH, Kerstjens-Frederikse WS, van der Vlies P, Hak E, Berger RMF, Groen H, Wilffert B.

Pharmacogenomics. 2017 Jun 22. doi: 10.2217/pgs-2017-0036. [Epub ahead of print]

PMID: 28639488

Similar articles

Select item 28635050

 

  1. Prediction of sustained fetal toxicity induced by ketoprofen based on PK/PD analysis using human placental perfusion and rat toxicity data.

Tanaka S, Kanagawa T, Momma K, Hori S, Satoh H, Nagamatsu T, Fujii T, Kimura T, Sawada Y.

Br J Clin Pharmacol. 2017 Jun 21. doi: 10.1111/bcp.13352. [Epub ahead of print]

PMID: 28635050

Similar articles

Select item 28639151

 

  1. Common Findings in Late-Gestation Fetal Echocardiography.

Tague L, Donofrio MT, Fulgium A, McCarter R, Limperopoulos C, Schidlow DN.

J Ultrasound Med. 2017 Jun 19. doi: 10.1002/jum.14283. [Epub ahead of print]

PMID: 28627028

Similar articles

Select item 28626924

 

  1. Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis.

Zhou C, Li C, Zhou B, Sun H, Koullourou V, Holt I, Puckelwartz MJ, Warren DT, Hayward R, Lin Z, Zhang L, Morris GE, McNally EM, Shackleton S, Rao L, Shanahan CM, Zhang Q.

Hum Mol Genet. 2017 Jun 15;26(12):2258-2276. doi: 10.1093/hmg/ddx116.

PMID: 28398466 Free PMC Article

Similar articles

Select item 28667725

 

  1. Single giant mediastinal rhabdomyoma as a sole manifestation of TSC in foetus.

Godava M, Filipova H, Dubrava L, Vrtel R, Michalkova K, Janikova M, Bakaj-Zbrozkova L, Navratil J.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017 Jun 12. doi: 10.5507/bp.2017.023. [Epub ahead of print]

PMID: 28659645

Similar articles

Select item 28605217

 

  1. The added value of f-TAPSE in the surveillance of pregnancies complicated by fetal and placental tumors.

Perlman S, Messing B, Salem Y, Porat S, Achiron R, Gilboa Y.

Prenat Diagn. 2017 Jun 11. doi: 10.1002/pd.5087. [Epub ahead of print]

PMID: 28603837

Similar articles

Select item 28605441

 

  1. The outcome of isolated prenatal ventricular size disproportion in the absence of aortic coarctation.

van Nisselrooij AEL, Rozendaal L, Linskens I, Clur SA, Hruda J, Pajkrt E, van Velzen CL, Blom NA, Haak MC.

Ultrasound Obstet Gynecol. 2017 Jun 9. doi: 10.1002/uog.17543. [Epub ahead of print]

PMID: 28598570

Similar articles

Select item 28592338

 

  1. Prenatal diagnosis of isolated total anomalous systemic venous connection to the left atrium.

Miltner B, Poncelet AJ, Barrea C.

Cardiol Young. 2017 Jun 8:1-4. doi: 10.1017/S1047951117000300. [Epub ahead of print]

PMID: 28592338

Similar articles

Select item 28602206

 

  1. Left Ventricular Rotational and Twist Mechanics in the Human Fetal Heart.

Li L, Craft M, Hsu HH, Zhang M, Klas B, Danford DA, Kutty S.

J Am Soc Echocardiogr. 2017 Jun 6. pii: S0894-7317(17)30278-X. doi: 10.1016/j.echo.2017.04.006. [Epub ahead of print]

PMID: 28599825

Similar articles

Select item 28660071

 

  1. Genome-Wide Association Studies and Meta-Analyses for Congenital Heart Defects.

Agopian AJ, Goldmuntz E, Hakonarson H, Sewda A, Taylor D, Mitchell LE; Pediatric Cardiac Genomics Consortium*.

Circ Cardiovasc Genet. 2017 Jun;10(3):e001449. doi: 10.1161/CIRCGENETICS.116.001449.

PMID: 28468790

Similar articles

Select item 28600328

 

  1. Right Atrial Dysfunction in the Fetus with Severely Regurgitant Tricuspid Valve Disease: A Potential Source of Cardiovascular Compromise.

Howley LW, Khoo NS, Moon-Grady AJ, Patel SS, Alrais F, Tworetzky W, Colen T, Brooks P, Trines J, Ojala T, Hornberger LK.

J Am Soc Echocardiogr. 2017 Jun;30(6):579-588. doi: 10.1016/j.echo.2017.01.002. Epub 2017 Apr 11.

PMID: 28410946

Similar articles

Select item 28391001

 

  1. Accelerated MRI of the fetal heart using compressed sensing and metric optimized gating.

Roy CW, Seed M, Macgowan CK.

Magn Reson Med. 2017 Jun;77(6):2125-2135. doi: 10.1002/mrm.26290. Epub 2016 Jun 2.

PMID: 27254315

Similar articles

Select item 28299430

 

  1. Counseling Practices for Fetal Hypoplastic Left Heart Syndrome.

Walsh MJ, Verghese GR, Ferguson ME, Fino NF, Goldberg DJ, Owens ST, Pinto N, Zyblewski SC, Quartermain MD.

Pediatr Cardiol. 2017 Jun;38(5):946-958. doi: 10.1007/s00246-017-1601-1. Epub 2017 Mar 27.

PMID: 28345115

Similar articles

Select item 28345114

 

  1. Assessment of Cardiac Function in Fetuses of Gestational Diabetic Mothers During the Second Trimester.

Atiq M, Ikram A, Hussain BM, Saleem B.

Pediatr Cardiol. 2017 Jun;38(5):941-945. doi: 10.1007/s00246-017-1600-2. Epub 2017 Mar 24.

PMID: 28337515

Similar articles

Select item 28321483

(No Ratings Yet)
Loading...Loading...

Fetal Cardiology Featured Articles of May 2017

Fetal Cardiology Reviews of May 2017 Manuscripts

 

Usefulness of the Prenatal Echocardiogram in Fetuses with Isolated Transposition of the Great Arteries to Predict the Need for Balloon Atrial Septostomy.

Vigneswaran TV, Zidere V, Miller OI, Simpson JM, Sharland GK.

Am J Cardiol. 2017 May 1;119(9):1463-1467. doi: 10.1016/j.amjcard.2017.01.017. Epub 2017 Feb 9.

PMID: 28283176

Similar articles

Select item 28262200

 

Take Home Points:

 

  • Following prenatal diagnosis of isolated d-transposition (D-TGA) of great arteries, prediction of fetuses requiring postnatal balloon atrial septostomy (BAS) remains challenging.
  • Restrictive atrial septum associated hypoxia continues to be a significant cause of morbidity in patients with a restrictive atrial septum.
  • To evaluate the usefulness of prenatal echocardiogram in predicting need for postnatal BAS, third trimester fetal echocardiographic characteristics including arterial valves, arterial duct, total septal length (TSL), and foramen ovale (FO) length were made, in addition to a subjective assessment of the atrial septum were evaluated in the study.
  • The foramen ovale (FO): total septal length (TSL) <0.5 had 99% sensitivity in identifying fetuses requiring balloon atrial septostomy in isolated D-TGA. FO: TSL was significantly smaller in those who required a BAS with good predictive value (area under the receiver operating characteristics curve: 0.80).
  • Restrictive movement of the atrial septum and smaller ovale length (6.8 ±2.8 mm vs. 8.8±1.7mm) is associated with higher likelihood of postnatal BAS.
  • Hypermobile and aneurysmal atrial septum was not associated with higher likelihood of postnatal BAS.

 

Shaji Menon Portrait 12.15.14Commentary from Dr. Shaji Menon (Salt Lake City), section editor of Pediatric Cardiology Journal Watch: This retrospective study from London, third trimester fetal echocardiograms of 40 cases of isolated TGA when compared to gestation matched control.  The factors evaluated in the prenatal echocardiogram included arterial valves, arterial duct, total septal length (TSL), and foramen ovale (FO) length were made, in addition to a subjective assessment of the atrial septum.  In emergency postnatal BAS was required and 12 out of 40 cases.  All 3 cases with limited movement of the atrial septum required emergency balloon atrial septostomy. The FO length in normal fetuses was not significantly different from those with TGA who did not require an emergency BAS but was significantly smaller in fetuses with TGA who required an emergency BAS (p < 0.01). The FO: TSL was significantly smaller in those who required an emergency BAS with good predictive value (area under the receiver operating characteristics curve: 0.80). The sensitivity for FO: TSL <0.5 was 99%. Hypermobile atrial septum was not associated with emergency BAS.

May fetal 1

May Fetal 2

May fetal 3

 

 

 

First-Trimester Fetal Echocardiography: Identification of Cardiac Structures for Screening from 6 to 13 Weeks’ Gestational Age.

Hutchinson D, McBrien A, Howley L, Yamamoto Y, Sekar P, Motan T, Jain V, Savard W, Hornberger LK.

J Am Soc Echocardiogr. 2017 May 13. pii: S0894-7317(17)30217-1. doi: 10.1016/j.echo.2017.03.017. [Epub ahead of print]

PMID: 28511860

Similar articles

Select item 28511801

 

Take Home Points:

 

  • Development of the fetal heart is generally complete by 7-8 weeks of gestation.
  • With advances in ultrasound technology fetal echocardiograms performed early in the gestation, 12-16 weeks, has been shown to be effective in identifying structural heart disease.
  • This study shows that very early fetal echocardiogram, as early as 8 weeks can be used to assess cardiac structure and color Doppler imaging enhances the diagnostic yield of fetal echocardiograms.
  • The best time for a complete early fetal echocardiogram excluding pulmonary veins appear to be around 11 weeks of gestation.

 

Commentary from Dr. Shaji Menon (Salt Lake City), section editor of Pediatric Cardiology Journal Watch: This is a single central prospective study evaluating the ability of fetal echocardiogram to visualize cardiac structure in the first trimester from as early as 6 weeks of gestation.  The study included a total of 261 early fetal echocardiographic examinations in 202 individual pregnancies, including 166 singletons, 33 sets of twins, and three sets of triplets.  All subjects underwent transabdominal scan.  Transvaginal scanning was used in addition to transabdominal scan in subjects less than 11 weeks of gestation.  Four chambers could be identified in 52% of patients in the eighth week (n = 12 of 23), improving to 80% (n = 36 of 45) in the 10th week and 98% (n = 57 of 58) by the 11th week. The inferior vena cava was seen by 2D imaging in only 4% (n = 1 of 23) in the eighth week, increasing to 13% (n = 6 of 45) by the 10th week and 80% (n = 25 of 31) by the 13th week.  Pulmonary veins could be assessed only after the 11th week.  Outflow tracts could be visualized by 2D imaging in 16% from 8-10 week and an 80% from 11-14 weeks.  Color Doppler imaging significantly improves the visualization of outflow tracts.

May Fetal 4

May fetal 5

May fetal 6

 

 

Fetal cardiology May 2017

 

  1. Fetal Cardiac US: Techniques and Normal Anatomy Correlated with Adult CT and MR Imaging.

Patel N, Narasimhan E, Kennedy A.

Radiographics. 2017 Jun 2:160126. doi: 10.1148/rg.2017160126. [Epub ahead of print]

PMID: 28574808

Similar articles

Select item 28328585

 

  1. Phenotyping cardiac and structural birth defects in fetal and newborn mice.

Liu X, Kim AJ, Reynolds W, Wu Y, Lo CW.

Birth Defects Res. 2017 Jun 1;109(10):778-790. doi: 10.1002/bdr2.1048. Epub 2017 May 22. Review.

PMID: 28544620

Similar articles

Select item 28457736

 

  1. A Targeted, Next-Generation Genetic Sequencing Study on Tetralogy of Fallot, Combined With Cleft Lip and Palate.

Liu L, Bu H, Yang Y, Tan Z, Zhang F, Hu S, Zhao T.

J Craniofac Surg. 2017 Jun;28(4):e351-e355. doi: 10.1097/SCS.0000000000003598.

PMID: 28230599

Similar articles

Select item 28285866

 

  1. Role of HDLive in Imaging the Fetal Heart.

Lakshmy SR, Jain B, Rose N.

J Ultrasound Med. 2017 Jun;36(6):1267-1278. doi: 10.7863/ultra.16.05071. Epub 2017 Mar 11.

PMID: 28295440

Similar articles

Select item 28384795

 

  1. Developmental Changes in Aortic Mechanical Properties in Normal Fetuses and Fetuses with Cardiovascular Disease.

Taketazu M, Sugimoto M, Saiki H, Ishido H, Masutani S, Senzaki H.

Pediatr Neonatol. 2017 Jun;58(3):245-250. doi: 10.1016/j.pedneo.2016.05.004. Epub 2016 Sep 28.

PMID: 27816335 Free Article

Similar articles

Select item 27870384

 

  1. Neonatal outcomes in fetuses with cardiac anomalies and the impact of delivery route.

Parikh LI, Grantz KL, Iqbal SN, Huang CC, Landy HJ, Fries MH, Reddy UM.

Am J Obstet Gynecol. 2017 May 31. pii: S0002-9378(17)30678-6. doi: 10.1016/j.ajog.2017.05.049. [Epub ahead of print]

PMID: 28578168

Similar articles

Select item 28570447

 

  1. The complex genetics of hypoplastic left heart syndrome.

Liu X, Yagi H, Saeed S, Bais AS, Gabriel GC, Chen Z, Peterson KA, Li Y, Schwartz MC, Reynolds WT, Saydmohammed M, Gibbs B, Wu Y, Devine W, Chatterjee B, Klena NT, Kostka D, de Mesy Bentley KL, Ganapathiraju MK, Dexheimer P, Leatherbury L, Khalifa O, Bhagat A, Zahid M, Pu W, Watkins S, Grossfeld P, Murray SA, Porter GA Jr, Tsang M, Martin LJ, Benson DW, Aronow BJ, Lo CW.

Nat Genet. 2017 May 22. doi: 10.1038/ng.3870. [Epub ahead of print]

PMID: 28530678

Similar articles

Select item 28534241

 

  1. Association Analysis of Nonsyndromic Congenital Heart Disease and Tag Single-Nucleotide Polymorphisms of TBX20 and Genes in the Ras-MAPK Pathway.

Luo Z, Shen Y, Chen W, Ma X, Liu L, Huang X, Yang Z, Sun H.

Genet Test Mol Biomarkers. 2017 May 19. doi: 10.1089/gtmb.2016.0369. [Epub ahead of print]

PMID: 28525297

Similar articles

Select item 28545853

 

  1. Epidemiology of Live Born Infants with Nonimmune Hydrops Fetalis-Insights from a Population-Based Dataset.

Steurer MA, Peyvandi S, Baer RJ, MacKenzie T, Li BC, Norton ME, Jelliffe-Pawlowski LL, Moon-Grady AJ.

J Pediatr. 2017 May 19. pii: S0022-3476(17)30508-5. doi: 10.1016/j.jpeds.2017.04.025. [Epub ahead of print]

PMID: 28533037

Similar articles

Select item 28533034

 

  1. Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis.

Yang C, Xu Y, Yu M, Lee D, Alharti S, Hellen N, Ahmad Shaik N, Banaganapalli B, Sheikh HAM, Ramu E, Przyborski S, Tenin G, Williams S, O’Sullivan J, Al-Radi OO, Atta J, Harding SE, Keavney B, Lako M, Armstrong L.

Hum Mol Genet. 2017 May 17. doi: 10.1093/hmg/ddx140. [Epub ahead of print]

PMID: 28521042

Similar articles

Select item 28515113

 

  1. First-Trimester Fetal Echocardiography: Identification of Cardiac Structures for Screening from 6 to 13 Weeks’ Gestational Age.

Hutchinson D, McBrien A, Howley L, Yamamoto Y, Sekar P, Motan T, Jain V, Savard W, Hornberger LK.

J Am Soc Echocardiogr. 2017 May 13. pii: S0894-7317(17)30217-1. doi: 10.1016/j.echo.2017.03.017. [Epub ahead of print]

PMID: 28511860

Similar articles

Select item 28511801

 

  1. Chromosome microarray analysis in the investigation of children with congenital heart disease.

Wu XL, Li R, Fu F, Pan M, Han J, Yang X, Zhang YL, Li FT, Liao C.

BMC Pediatr. 2017 May 4;17(1):117. doi: 10.1186/s12887-017-0863-3.

PMID: 28472932 Free PMC Article

Similar articles

Select item 28471087

 

  1. An antenatal marker of neurodevelopmental outcomes in infants with congenital heart disease.

Siddiqui S, Fifer WP, Ordonez-Retamar M, Nugent JD, Williams IA.

J Perinatol. 2017 May 4. doi: 10.1038/jp.2017.59. [Epub ahead of print]

PMID: 28471442

Similar articles

 

  1. Usefulness of the Prenatal Echocardiogram in Fetuses With Isolated Transposition of the Great Arteries to Predict the Need for Balloon Atrial Septostomy.

Vigneswaran TV, Zidere V, Miller OI, Simpson JM, Sharland GK.

Am J Cardiol. 2017 May 1;119(9):1463-1467. doi: 10.1016/j.amjcard.2017.01.017. Epub 2017 Feb 9.

PMID: 28283176

Similar articles

Select item 28262200

 

  1. Association of genetic polymorphisms of de novo nucleotide biosynthesis with increased CHD susceptibility in the northern Chinese population.

Jiang YC, Kuang LL, Sun SN, Duan WY, Qiao B, Wang HY.

Clin Genet. 2017 May;91(5):748-755. doi: 10.1111/cge.12874. Epub 2016 Dec 12.

PMID: 27659940

Similar articles

Select item 28240666

 

  1. Increased regurgitant flow causes endocardial cushion defects in an avian embryonic model of congenital heart disease.

Ford SM, McPheeters MT, Wang YT, Ma P, Gu S, Strainic J, Snyder C, Rollins AM, Watanabe M, Jenkins MW.

Congenit Heart Dis. 2017 May;12(3):322-331. doi: 10.1111/chd.12443. Epub 2017 Feb 17.

PMID: 28211263

Similar articles

Select item 28205344

 

  1. TCF21 rs12190287 Polymorphisms Are Associated with Ventricular Septal Defects in a Chinese Population.

Yang L, Gao X, Luo H, Huang Q, Su D, Tan X, Lu C.

Genet Test Mol Biomarkers. 2017 May;21(5):312-315. doi: 10.1089/gtmb.2016.0324. Epub 2017 Mar 27.

PMID: 28346832

Similar articles

Select item 28366291

 

  1. Placental Characteristics of Fetuses With Congenital Heart Disease.

Albalawi A, Brancusi F, Askin F, Ehsanipoor R, Wang J, Burd I, Sekar P.

J Ultrasound Med. 2017 May;36(5):965-972. doi: 10.7863/ultra.16.04023. Epub 2017 Mar 4.

PMID: 28258617

Similar articles

Select item 28258609

 

  1. Prenatal Diagnosis of a Retroesophageal Left Brachiocephalic Vein: Two Case Reports.

Cheng YKY, Law KM, Chak PK, To KF, Chan YM, Leung TY.

J Ultrasound Med. 2017 May;36(5):1065-1069. doi: 10.7863/ultra.16.05003. Epub 2017 Mar 4.

PMID: 28258609

Similar articles

Select item 28230264

 

  1. Associations of GATA4 genetic mutations with the risk of congenital heart disease: A meta-analysis.

Zhang Y, Ai F, Zheng J, Peng B.

Medicine (Baltimore). 2017 May;96(18):e6857. doi: 10.1097/MD.0000000000006857.

PMID: 28471988 Free PMC Article

Similar articles

Select item 28358424

 

  1. Exome sequencing reveals novel IRXI mutation in congenital heart disease.

Guo C, Wang Q, Wang Y, Yang L, Luo H, Cao XF, An L, Qiu Y, Du M, Ma X, Li H, Lu C.

Mol Med Rep. 2017 May;15(5):3193-3197. doi: 10.3892/mmr.2017.6410. Epub 2017 Mar 30.

PMID: 28358424

Similar articles

Select item 28260051

 

  1. MicroRNA-1 upregulation promotes myocardiocyte proliferation and suppresses apoptosis during heart development.

Liu L, Yuan Y, He X, Xia X, Mo X.

Mol Med Rep. 2017 May;15(5):2837-2842. doi: 10.3892/mmr.2017.6282. Epub 2017 Mar 3.

PMID: 28260051

Similar articles

Select item 28259930

 

  1. Myocardial deformation in fetuses with coarctation of the aorta: a case-control study.

Miranda JO, Hunter L, Tibby S, Sharland G, Miller O, Simpson JM.

Ultrasound Obstet Gynecol. 2017 May;49(5):623-629. doi: 10.1002/uog.15939.

PMID: 27072120

Similar articles

Select item 28520543

 

  1. Abnormal Fetal Findings Associated With a Global Sphericity Index of the 4-Chamber View Below the 5th Centile.

DeVore GR, Satou G, Sklansky M.

J Ultrasound Med. 2017 May 30. doi: 10.1002/jum.14261. [Epub ahead of print]

PMID: 28556937

Similar articles

Select item 28555404

 

  1. Antenatal diagnosis of double-outlet left atrium.

Vaksmann G, Bouzguenda I, Houyel L.

Cardiol Young. 2017 May;27(4):816-818. doi: 10.1017/S104795111600250X. Epub 2017 Jan 12.

PMID: 28077186

Similar articles

Select item 28077185

 

  1. Prenatal diagnosis of absent pulmonary valve syndrome from first trimester onwards: novel insights into pathophysiology, associated conditions and outcome.

Gottschalk I, Jehle C, Herberg U, Breuer J, Brockmeier K, Bennink G, Hellmund A, Strizek B, Gembruch U, Geipel A, Berg C.

Ultrasound Obstet Gynecol. 2017 May;49(5):637-642. doi: 10.1002/uog.15977. Epub 2017 Apr 5.

PMID: 27240926

Similar articles

 

(No Ratings Yet)
Loading...Loading...

Fetal Cardiology Featured Articles of April 2017

 

Fetal Cardiology Reviews of April 2017 Manuscripts

 

Fetal cardiac cine imaging using highly accelerated dynamic MRI with retrospective motion correction and outlier rejection.

van Amerom JF, Lloyd DF, Price AN, Kuklisova Murgasova M, Aljabar P, Malik SJ, Lohezic M, Rutherford MA, Pushparajah K, Razavi R, Hajnal JV.

Magn Reson Med. 2017 Apr 3. doi: 10.1002/mrm.26686. [Epub ahead of print]

PMID: 28370252

Similar articles

Select item 28393221

 

Take Home Points:

  • A multi-step strategy for reconstruction of 2D fetal cardiac MRI cine images including acquisition of highly accelerated MRI data, cardiac synchronization, motion correction, outlier rejection and cardiac cine reconstruction is demonstrated
  • The researchers could show that this method is able to improve fetal cardiac MRI cine imaging.

 

Voges IngaCommentary from Dr. Inga Voges (London UK), section editor of Congenital Heart Surgery Journal Watch: Fetal cardiac magnetic resonance imaging (MRI) has the potential to complement fetal echocardiography and is increasingly being used. However, the MRI exam is challenging because of various fetal movements. This nice study proposes a multi-step strategy involving acquisition of highly accelerated MRI data and image reconstruction, cardiac synchronization, motion correction, outlier rejection and cardiac cine reconstruction. 30 pregnant women were scanned and 36 cine cardiac MRI data sets were successfully reconstructed using the proposed method (see figures).  Image quality and each step of the described strategy were evaluated. The authors show that the combination of the post-processing steps improved the image quality (see figures) and that this approach seems to be promising for further fetal cardiac MRI studies.

Fetal 1 april

Fetasl 2 april

Right Atrial Dysfunction in the Fetus with Severely Regurgitant Tricuspid Valve Disease: A Potential Source of Cardiovascular Compromise.

Howley LW, Khoo NS, Moon-Grady AJ, Patel SS, Alrais F, Tworetzky W, Colen T, Brooks P, Trines J, Ojala T, Hornberger LK.

J Am Soc Echocardiogr. 2017 Apr 11. pii: S0894-7317(17)30002-0. doi: 10.1016/j.echo.2017.01.002. [Epub ahead of print]

PMID: 28410946

Similar articles

Select item 28399889

 

Take Home Points:

 

  • Fetal tricuspid valve disease has more severe right atrial dilation and dysfunction than compared to right heart obstruction only and control groups.
  • RA dysfunction may have a critical influence in the worsened outcomes and higher incidence of hydrops in these patients.

Hershenson, JaredCommentary from Dr. Jared Hershenson (Greater Washington DC), section editor of Fetal Cardiology Journal Watch:  Fetal tricuspid valve disease with significant tricuspid regurgitation (rTVD) is associated with hydrops, sudden fetal demise, or hemodynamic instability after birth, but the pathophysiology has not been completely defined. As most structural heart defects are well tolerated in fetal life, atrial dysfunction was hypothesized to have a significant effect due to potential decreases in left ventricular filling and output and increased right atrial and central venous pressure. This study compared RA function of those with rTVD vs. those with right heart obstruction (RHO) and control patients over a 10-year period. The groups used velocity vector imaging to measure some novel measures of atrial function, including RA emptying fraction (measure of global atrial function) and atrial volume expansion index (measure of atrial reservoir function), as well as other standard fetal echo measurements. Groups were compared using standard statistical measures and univariable logistic regression was performed to identify the factors associated with death. rTVD patients had increased RA volume, reduced emptying, decreased emptying fraction and decreased fractional area change than those with RHO alone. LV Tei index and umbilical artery pulsatility index were greatest in rTVD as compared to RHO and control groups. ~ 27% of fetuses with rTVD died during fetal life or within the neonatal period, with those with functional pulmonary atresia having the worse outcomes. This was in contrast with a 6.5% mortality in the RHO group. 11.8% of rTVD developed hydrops vs. 5% in RHO. Three RA function parameters were associated with demise, including RA indexed emptying rate, RA maximum volume, and RA minimum area. Based on the data, the authors suspect that decreased atrial contraction and reservoir functioning in the rTVD group may lead to decreased flow across the PFO resulting in less LV filling and a drop in cardiac output which could explain the higher incidence of hydrops and fetal demise.

Fetal 3 april

Fetal 4 april

fetal 5 april

Fetal Cardiology April 2017

 

  1. Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice.

Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T.

J Clin Invest. 2017 Apr 24. pii: 88725. doi: 10.1172/JCI88725. [Epub ahead of print]

PMID: 28436940 Free Article

Similar articles

Select item 28436549

 

  1. Human fetal heart specific coexpression network involves congenital heart disease/defect candidate genes.

Wang B, You G, Fu Q.

Sci Rep. 2017 Apr 24;7:46760. doi: 10.1038/srep46760.

PMID: 28436429 Free PMC Article

Similar articles

Select item 28432402

 

  1. Variable phenotype in a novel mutation in PHOX2B.

Lombardo RC, Kramer E, Cnota JF, Sawnani H, Hopkin RJ.

Am J Med Genet A. 2017 Apr 19. doi: 10.1002/ajmg.a.38218. [Epub ahead of print]

PMID: 28422456

Similar articles

Select item 28422173

 

  1. Demographic and perinatal outcome data of fetuses with SUA/PRUV.

Sun L, Wang Y.

J Matern Fetal Neonatal Med. 2017 Apr 3:1-6. doi: 10.1080/14767058.2017.1309384. [Epub ahead of print]

PMID: 28320222

Similar articles

Select item 28372585

 

  1. Multiple gene variations contributed to congenital heart disease via GATA family transcriptional regulation.

Qian Y, Xiao D, Guo X, Chen H, Hao L, Ma X, Huang G, Ma D, Wang H.

J Transl Med. 2017 Apr 3;15(1):69. doi: 10.1186/s12967-017-1173-0.

PMID: 28372585 Free PMC Article

Similar articles

Select item 28370096

 

  1. Recipient Twin Circular Shunt Physiology Before Fetal Laser Surgery: Survival and Risks for Postnatal Right Ventricular Outflow Tract Obstruction.

Pruetz JD, Votava-Smith JK, Chmait HR, Korst LM, Llanes A, Chmait RH.

J Ultrasound Med. 2017 Apr 3. doi: 10.7863/ultra.16.08038. [Epub ahead of print]

PMID: 28370096

Similar articles

Select item 28370380

 

  1. Fetal cardiac cine imaging using highly accelerated dynamic MRI with retrospective motion correction and outlier rejection.

van Amerom JF, Lloyd DF, Price AN, Kuklisova Murgasova M, Aljabar P, Malik SJ, Lohezic M, Rutherford MA, Pushparajah K, Razavi R, Hajnal JV.

Magn Reson Med. 2017 Apr 3. doi: 10.1002/mrm.26686. [Epub ahead of print]

PMID: 28370252

Similar articles

Select item 28393221

 

  1. Prenatal diagnosis of congenital heart diseases by fetal echocardiography in second trimester: a Chinese multicenter study.

Chu C, Yan Y, Ren Y, Li X, Gui Y.

Acta Obstet Gynecol Scand. 2017 Apr;96(4):454-463. doi: 10.1111/aogs.13085. Epub 2017 Feb 13.

PMID: 28029179

Similar articles

Select item 28242012

 

  1. Genetics of Congenital Heart Disease: Past and Present.

Muntean I, Togănel R, Benedek T.

Biochem Genet. 2017 Apr;55(2):105-123. doi: 10.1007/s10528-016-9780-7. Epub 2016 Nov 2. Review.

PMID: 27807680

Similar articles

Select item 27938448

 

  1. An update on the molecular diagnosis of congenital heart disease: focus on loss-of-function mutations.

Li YJ, Yang YQ.

Expert Rev Mol Diagn. 2017 Apr;17(4):393-401. doi: 10.1080/14737159.2017.1300062. Epub 2017 Mar 8.

PMID: 28274167

Similar articles

Select item 26572766

 

  1. Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit.

Zakariyah AF, Rajgara RF, Veinot JP, Skerjanc IS, Burgon PG.

J Mol Cell Cardiol. 2017 Apr;105:89-98. doi: 10.1016/j.yjmcc.2017.03.003. Epub 2017 Mar 14.

PMID: 28302382

Similar articles

Select item 28109537

 

  1. CITED2 Mutations in Conserved Regions Contribute to Conotruncal Heart Defects in Chinese Children.

Li B, Pu T, Liu Y, Xu Y, Xu R.

DNA Cell Biol. 2017 Apr 24. doi: 10.1089/dna.2017.3701. [Epub ahead of print]

PMID: 28436679

Similar articles

Select item 28436859

 

  1. The 24-Segment Sphericity Index: A New Technique to Evaluate Fetal Cardiac Diastolic Shape.

DeVore GR, Klas B, Satou G, Sklansky M.

Ultrasound Obstet Gynecol. 2017 Apr 24. doi: 10.1002/uog.17505. [Epub ahead of print]

PMID: 28437575

Similar articles

Select item 28461021

 

  1. EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent.

Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, Wang DZ, Yu J, Pu WT, He A.

Elife. 2017 Apr 10;6. pii: e24570. doi: 10.7554/eLife.24570.

PMID: 28394251 Free PMC Article

Similar articles

Select item 28443268

 

  1. EXIT procedure for fetal mediastinal teratoma with large pericardial effusion: a case report with review of literature.

Agarwal A, Rosenkranz E, Yasin S, Swaminathan S.

J Matern Fetal Neonatal Med. 2017 Apr 2:1-5. doi: 10.1080/14767058.2017.1306851. [Epub ahead of print]

PMID: 28288537

Similar articles

Select item 28441822

 

  1. Microarray Analysis of Differential Gene Expression Profile Between Human Fetal and Adult Heart.

Geng Z, Wang J, Pan L, Li M, Zhang J, Cai X, Chu M.

Pediatr Cardiol. 2017 Apr;38(4):700-706. doi: 10.1007/s00246-017-1569-x. Epub 2017 Mar 22.

PMID: 28331934

Similar articles

Select item 28315942

 

(No Ratings Yet)
Loading...Loading...