Bortezomib use in a pediatric cardiac transplant center

Bortezomib use in a pediatric cardiac transplant center.

Zinn MD, L’Ecuyer TJ, Fagoaga OR, Aggarwal S.

Pediatr Transplant. 2014 Aug;18(5):469-76. doi: 10.1111/petr.12300. Epub 2014 Jun 14.

PMID: 24931171 [PubMed – in process]

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Select item 24814282

Comment from Dr. Hafil B. Abdulgani, section editor of Congenital Heart Journal Watch’s CHD Surgery: Bortezomib rescue has been durably effective in salvaging patients with refractory antibody mediated rejection (AMR), a therapeutic challenge in human heart transplantation.  In 2005, the International Society of Heart Transplantation (IHLT) published specific guidelines in the diagnosis of AMR, followed by updated consensus in 2011. The development of evidence-based guidelines for the management of AMR in heart transplantation is greatly needed. Although it is widely accepted that AMR associated with allograft dysfunction should be aggressively treated, the management of asymptomatic AMR is less clear. This excellent paper gives a new insight on Bortezomib mechanism of action and therapeutic indication, with specific emphasis, in pediatric transplantation.

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Granulocyte Colony Stimulating Factor Reduces Brain Injury in a Cardiopulmonary Bypass-Circulatory Arrest Model of Ischemia in a Newborn Piglet

Granulocyte Colony Stimulating Factor Reduces Brain Injury in a Cardiopulmonary Bypass-Circulatory Arrest Model of Ischemia in a Newborn Piglet.

Pastuszko P, Schears GJ, Greeley WJ, Kubin J, Wilson DF, Pastuszko A.

Neurochem Res. 2014 Aug 1. [Epub ahead of print]

PMID: 25082120 [PubMed – as supplied by publisher]

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Select item 24646416

Comment from Dr. Hafil B. Abdulgani, section editor of Congenital Heart Journal Watch’s CHD Surgery: With the standard technique of DHCA it was highly unlikely that any difference could be detected in neurodevelopment outcome relative to continuous CPB. Problems with recent developments, i.e. retrograde cerebral perfusion, antegrade cerebral perfusion through one arch vessel are lack of homogenous perfusion of the brain and in possible accurate intracardiac reconstruction. Innovative G-CSF, documented in this paper, may be useful in cases where DHCA is unquestionably indicated, e.g. neonatal repair of TAPC, CAVC, SVC to coronary sinus, and stage-1 Norwood arch reconstruction.

 

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Pediatric heart transplantation-indications and outcomes in the current era

Pediatric heart transplantation-indications and outcomes in the current era.

Thrush PT, Hoffman TM.

J Thorac Dis. 2014 Aug;6(8):1080-96. doi: 10.3978/j.issn.2072-1439.2014.06.16. Review.

PMID: 25132975 [PubMed] Free PMC Article

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Select item 25132969

Comment from Dr. Hafil B. Abdulgani, section editor of Congenital Heart Journal Watch’s CHD Surgery: An excellent review on the current status of pediatric heart transplantation.

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The results of a two-stage double switch operation for congenital corrected transposition of the great arteries with a deconditioned morphologically left ventricle

The results of a two-stage double switch operation for congenital corrected transposition of the great arteries with a deconditioned morphologically left ventricle.

Cui B, Li S, Yan J, Shen X, Wang X, Yang K, Hua Z, Wang Q, Tian M.

Interact Cardiovasc Thorac Surg. 2014 Aug 30. pii: ivu274. [Epub ahead of print]

PMID: 25173927 [PubMed – as supplied by publisher]

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Select item 25167212

Comment from Dr. Hafil B. Abdulgani, section editor of Congenital Heart Journal Watch’s CHD Surgery: The double-switch operation is a technically demanding procedure that requires a long cross-clamp time in many surgeons’ hands, as depicted by authors of this elegant paper. It would be interesting to know if the length of interval between the first and the second stage operation influence the degree of difficulties encountered intraoperatively. Cellular modulation to enhance plausible mLV for second-stage procedure may well be the next frontier; because, load induction hypertrophy may not be applicable in all cases.

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